Group Palotie - Terwilliger

MOLECULAR GENETICS OF MIGRAINE

The overall goal of the group is to study the genetic susceptibility of complex neurological traits. The main focus for the past six years has been genetics of migraine and multiple sclerosis (MS). Our strategy has been to combine best possible phenotyping in large samples with cutting edge genetic techniques, including high throughput genotyping and novel tools of statistical genetics. We aim to identify gene variants and assess their impact in ascertained family and case control samples and subsequently study their population relevance in large international population samples. The strategy of the group is based on strong involvement of clinical researchers for accurate phenotyping and optimal study design.
 

MOST IMPORTANT PUBLICATIONS:

Wessman M, Kallela M, Kaunisto M, Marttila P, Sobel E, Hartiala J, Oswell G, Leal S, Papp J, Hämäläinen E, Broas P, Joslyn G, Hovatta I, Hiekkalinna T, Kaprio J, Ott J, Cantor R, Zwart J-A, Ilmavirta M, Havanka H, Färkkilä M, Peltonen L, Palotie A. A Susceptibility Locus for Migraine with Aura, on Chromosome 4q24. Am J Hum Genet 70:652-662, 2002

Chen DC, Saarela J, Clark RA, Miettinen T, Chi A, Eichler EE, Peltonen L, Palotie A. Segmental duplications flank the multiple sclerosis locus on chromosome 17q. Genome Res. 2004 Aug;14(8):1483-92

Anttila V, Kallela M, Oswell G, Kaunisto M, Nyholt D, Hämäläinen E, Havanka H, Ilmavirta M, Terwilliger J, Sobel E, Peltonen L, Kaprio J, Färkkilä M, Wessman M, Palotie A: Trait components provide tools to dissect the genetic susceptibility of migraine. Am J Hum Genet 79:85-99, 2006.

Saarela J, Kallio SP, Chen D, Montpetit A, Jokiaho A, Choi E, Asselta R, Bronnikov D, Lincoln MR, Sadovnick AD, Tienari PJ, Koivisto K, Palotie A, Ebers GC, Hudson TJ, Peltonen L: PRKCA and Multiple Sclerosis: Association in Two Independent Populations. PloS Genetics 2:e42, 2006

Peltonen L, Perola M, Naukkarinen J, Palotie A. Lessons from studying monogenic disease for common disease. Hum Mol Gen 15: R67-74, 2006

Imanishi T, Itoh T, Suzuki Y, O’Donovan C, Fukuchi S, Koyanagi KO, Barrero RA, Tamura T, Yamaguchi-Kabata Y, Tanino M, Yura K, Miyazaki S, Ikeo K, Homma K, Kasprzyk A, Nishikawa T, Hirakawa M, Thierry-Mieg D, Ashurst J, Jia L, Nakao M, Thomas MA, Mulder N, Karavidopoulou Y, Jin L, Kim S, Yasuda T, Lenhard B, Eveno E, Suzuki Y, Yamasaki C, Takeda J, Gough C, Hilton P, Fujii Y, Sakai H, Tanaka S, Amid C, Bellgard M, de Fatima Bonaldo M, Bono H, Bromberg SK, Brookes A, Bruford E, Carnici P, Chelala C, Couillault C, de Souza SJ, Debilly M-A, Devignes M-D, Dubchak I, Endo T, Estreicher A, Eyras E, Fukami-Kobayashi K, Gopinathrao G, Graudens E, Hahn Y, Han M, Han Z, Hanada K, Hanaoka H, Harada E, Hashimoto K, Hinz U, Hirai M, Hishiki T, Hopkinson I, Imbeaud S, Inoko H, Kanapin A, Kaneko Y, Kasukawa T, Kelso J, Kersey P, Kikuno R, Kimura K, Korn B, Kuryshev V, Makalowska I, Makino T, Mano S, Mariage-Samson R, Mashima J, Matsuda H, Mewes H-W, Minoshima S, Nagai K, Nagasaki H, Nagata N, Nigam R, Ogasawara O, Ohara O, Ohtsubo M, Okada N, Okido T, Oota S, Ota M, Ota T, Otsuki T, Piatier-Tonneau D, Poustka A, Ren SX, Saitou N, Sakai K, Sakamoto S, Sakate R, Schupp I, Servant F, Sherry S, Shiba R, Shimizu N, Shimoyama M, Simpson AJ, Soares B, Steward C, Suwa M, Suzuki M, Takahashi A, Tamiya G, Tanaka H, Taylor T, Terwilliger JD, Unneberg P, Veeramachaneni V, Watanabe S, Wilming L, Yasuda N, Yoo H-S, Stodolsky M, Makalowski W, Go M, Nakai K, Takagi T, Kanehisa M, Sakaki Y, Quackenbush J, Okazaki Y, Hayashizaki Y, Hide W, Chakraborty R, Nishikawa K, Sugawara H, Tateno Y, Chen Z, Oishi M, Tonellato P, Apweiler R, Okubo K, Wagner L, Wiemann S, Strausberg RL, Isogai T, Auffray C, Nomura N, Gojobori T, Sugano S. (2004) Integrative Annotation of 21,037 Human Genes Validated by Full-Length cDNA Clones. PloS Biol 2(6): e166.

Göring HHH, Terwilliger JD: Linkage analysis in the presence of errors I: Complex-valued recombination fractions and complex phenotypes. Am J Hum Genet. 66: 1095-1106, 2000

Göring HHH, Terwilliger JD: Linkage analysis in the presence of errors II: Marker-locus genotyping errors modeled with hypercomplex recombination fractions. Am J Hum Genet. 66: 1107-1118, 2000