Collaborative MORGAM publications

In addition to the collaborative publications listed here, there are numerous publications from the individual MORGAM Centres.

Original printed collaborative articles

1. Evans A, Salomaa V, Kulathinal S, Asplund K, Cambien F, Ferrario M, Perola M, Peltonen L, Shields D, Tunstall-Pedoe H, Kuulasmaa K, for the MORGAM Project. MORGAM (an international pooling of cardiovascular cohorts). Int J Epidemiol 2005;34:21-27. [PubMed]
2. Kulathinal S, Karvanen J, Saarela O, Kuulasmaa K, for the MORGAM Project. Case-cohort design in practice — experiences from The MORGAM Project. Epidemiol Perspect Innov 2007;4:15  doi:10.1186/1742-5573-4-15 [Open access article]
3. Grisoni M-L, Proust C, Alanne M, DeSuremain M, Salomaa V, Kuulasmaa K, Cambien F, Nicaud V, Stegmayr B, Virtamo J, Shields D, Kee F, Tiret L, Evans A, Tregouet D-A, for The MORGAM Project. Haplotypic analysis of tag SNPs of the interleukin-18 gene in relation to cardiovascular disease events: The MORGAM Project. Eur J Hum Genet 2008;16:1512-20. [PubMed]
4. Karvanen J, Silander K, Kee F, Tiret L, Salomaa V, Kuulasmaa K, Wiklund P-G, Virtamo J, Saarela O, Perret C, Perola M, Peltonen L, Cambien F, Erdmann J, Samani N. J., Schunkert H, Evans A, for the MORGAM Project. The impact of newly-identified loci on coronary heart disease, stroke and total mortality in the MORGAM prospective cohorts. Genet Epidemiol.  2009;33:237-246. [PubMed]
5. Coronary Artery Disease Consortium. Large scale association analysis of novel genetic loci for coronary artery disease. Arterioscler Thromb Vasc Biol. 2009;29:774-780. [PubMed]
6. Asplund K, Karvanen J, Giampaoli S, Jousilahti P, Niemelä M, Broda G, Cesana G, Dallongeville J, Ducimetriere P, Evans A, Ferrières J, Haas B, Jorgensen T, Tamosiunas A, Vanuzzo D, Wiklund PG, Yarnell J, Kuulasmaa K, Kulathinal S, for the MORGAM Project. Relative risks for stroke by age, sex and population based on follow-up of 18 European populations in the MORGAM Project. Stroke 2009;40:2319-2326. [PubMed]
7. Grisoni ML, Proust C, Alanne M, DeSuremain M, Salomaa V, Kuulasmaa K, Cambien F, Nicaud V, Wiklund PG, Virtamo J, Kee F, Tiret L, Evans A, Tregouet DA. Lack of association between polymorphisms of the IL18R1 and IL18RAP genes and cardiovascular risk: the MORGAM Project. BMC Med Genet. 2009;10:44. doi:10.1186/1471-2350-10-44. [Open access article]
8. Blankenberg S, Zeller T, Saarela O, Havulinna AS, Kee F, Tunstall-Pedoe H, Kuulasmaa K, Yarnell J, Schnabel RB, Wild PS, Münzel TF, Lackner KJ, Tiret L, Evans A, Salomaa V; for the MORGAM Project. Contribution of 30 biomarkers to 10-year cardiovascular risk estimation in 2 population cohorts; the MORGAM – the MONICA, Risk. Genetics, Archiving, and Monograph (MORGAM) Biomarker Project. Circulation  2010;121;2388-2397. [PubMed]
9. Borglykke A, Andreasen AH, Kuulasmaa K, Sans S, Ducimetière P, Vanuzzo D, Ferrario MM, Palmieri L, Karvanen J, Tunstall-Pedoe H, Jørgensen T; on behalf of the MORGAM Project. Stroke risk estimation across nine European countries in the MORGAM project. Heart 2010;96:1997-2004. [PubMed]
10. Vangjeli C, Dicker P, Tregouet DA, Shields DC, Evans A, Stanton AV; for the MORGAM project. A polymorphism in ACE2 is associated with a lower risk for fatal cardiovascular events in females: The MORGAM project. J Renin Angiotensin Aldosterone Syst. 2011;12:504-509. [PubMed]
11. Bodenant M, Kuulasmaa K, Wagner A, Kee F, Palmieri L, Ferrario MM, Montaye M, Amouyel P, Dallongeville J; for the MORGAM Project. Measures of abdominal adiposity and the risk of stroke: The MOnica Risk, Genetics, Archiving and Monograph (MORGAM) Study. Stroke. 2011;42:2872-2877. [PubMed]
12. Wild PS, Zeller T, Schillert A, Szymczak S, Sinning CR, Deiseroth a, Schnabel RB, Lubos E, Keller T, Eleftheriadis MS, Bickel C, Rupprecht HJ, Wilde S, Rossmann H, Linsel-Nitschke P, Cupples LA, Perret V, Erdmann J, Stark K, Kleber ME, Epstein SE, Voight BF, Kuulasmaa K, Li M, Schäfer AS, Klopp N, Braund PS, Sager H, Demissie S, Proust C, König IR, Wichmann HE, Reinhard W, Hoffmann MM, Virtamo J, Burnett MS, Siscovick D, Wiklund PG, Qu L, El Mokthari NE, Thompson JR, Peters A, Smith AV, Yon E, Baumert J, Hengstenberg C, März W, Amouyel P, Devaney J, Schwartz SM, Saarela O, Mehta NN, Rubin D, Silander K, Hall AS , Ferrieres J, Harris TB, Melander O, Kee F, Hakonarson H, Schrezenmeir J, Gudnason V, Elosua R, Arveiler D, Evans A, Rader DJ, Illig T, Schreiber S, Bis JC, Altshuler D, Kavousi M, Witteman JCM, Uitterlinden AG, Hofman A, Folsom AR, Barbalic M, Boerwinkle E, Kathiresan S, Reilly MP, O'Donnell CJ, Samani NJ, Schunkert H, Cambien F, Lackner KJ, Tiret L, Salomaa V, Munzel T, Ziegler A, Blankenberg S. A genome-wide association study identifies LIPA as a susceptibility gene for coronary artery disease. Circ Cardiovasc Genet. 2011;4:403-12. [PubMed]
13. Hughes MF, Saarela O, Blankenberg S, Zeller T, Havulinna AS, Kuulasmaa K, Yarnell J, Schnabel RB, Tiret L, Salomaa V, Evans A, Kee F; for the MORGAM Project. A multiple biomarker risk score for guiding clinical decisions using a decision curve approach. Eur J Cardiovasc Prev Rehabil. 2011. Epub ahead of print. [PubMed]

Methodological papers originating from the MORGAM Project

1. Silander K, Komulainen K, Ellonen P, Jussila M, Alanne M, Levander M, Tainola P, Kuulasmaa K, Salomaa V, Perola M, Peltonen L, Saarela J. Evaluating whole genome amplification via multiply-primed rolling circle amplification for SNP genotyping of samples with low DNA yield. Twin Res Hum Genet. 2005;8:368–375. [PubMed]
2. Kulathinal S, Arjas E. Bayesian inference from case-cohort data with multiple end-points. Scand J Statist. 2006;33:25–36.
3. Saarela O, Kulathinal S. Conditional likelihood inference in a case-cohort design: an application to haplotype analysis. The International Journal of Biostatistics. 2007;3:Iss. 1, Article 1. Available from: http://www.bepress.com/ijb/vol3/iss1/1
4. Karvanen J, Veronesi G, Kuulasmaa K. Defining thirds of schooling years in population studies. Eur J Epidemiol. 2007;22:487–92. [PubMed]
5. Saarela O, Kulathinal S, Arjas E, Läärä E. Nested case-control data utilized for multiple outcomes: a likelihood approach and alternatives. Statistics in Medicine. 2008;27:5991–6008.
6. Saarela O, Kulathinal S, Karvanen J. Joint analysis of prevalence and incidence data using conditional likelihood. Biostatistics, 2009;10:575–587.
7. Karvanen J, Kulathinal S, Gasbarra D. Optimal designs to select individuals for genotyping conditional on observed binary or survival outcomes and non-genetic covariates. Computational Statistics & Data Analysis, 2009;53:1782–1793.
8. Karvanen J,  Harrell FE. Visualizing covariates in proportional hazards model. Statistics in Medicine, 2009;28:1957–1966.
9. Karvanen J, Saarela O, Kuulasmaa K. Nonparametric multiple imputation of left censored event times in analysis of follow-up data. Journal of Data Science 2010;8:151-172. Available from: http://www.jds-online.com/file_download/231/JDS-495.pdf

Publications in the World Wide Web

1. MORGAM Project. MORGAM Manual. (2001-). Available from URL:http://www.ktl.fi/publications/morgam/manual/contents.htm, URN:NBN:fi-fe20041529.
2. Kulathinal S, Niemelä M, Kuulasmaa K, contributors from Participating Centres, for the MORGAM Project. Description of MORGAM Cohorts. (2005). Available from URL:http://www.ktl.fi/publications/morgam/cohorts/index.html, URN:NBN:fi-fe20051214.
3. Niemelä M, Kulathinal S and Kuulasmaa K, editors,  for the MORGAM Project. Description and quality assessment of MORGAM data. (2007). Available from URL:http://www.ktl.fi/publications/morgam/qa/contents.htm, URN:NBN:fi-fe20071495.
   • Cepaitis Z, Joseph B, Niemelä M, Saarela O, Kuulasmaa K, for the MORGAM Project. Record inventory and routine data checking. (2007). Available from URL:http://www.ktl.fi/publications/morgam/qa/inventory/invinf.htm.
   • Kulathinal S, Kuulasmaa K, for the MORGAM Project. Description and quality of the cohorts. (2007). Available from URL:http://www.ktl.fi/publications/morgam/qa/baseline/qa_cohorts/cohortsqa.htm.
   • Kuulasmaa K, Kulathinal S, Niemelä M, for the MORGAM Project. Description and quality of the baseline data: Introduction. (2007). Available from URL:http://www.ktl.fi/publications/morgam/qa/baseline/qa_data/dataqa.htm.
   • Saarela O, Tolonen H, Kulathinal S, Niemelä M,Kuulasmaa K, for the MORGAM Project. Description and quality of baseline data: Smoking. (2007). Available from URL:http://www.ktl.fi/publications/morgam/qa/baseline/smoking/smokeqa.htm.
   • Kuulasmaa K, Niemelä M, Joseph B, for the MORGAM Project. Description and quality of baseline data: Blood pressure. (2007). Available from URL:http://www.ktl.fi/publications/morgam/qa/baseline/bp/bpqa.htm.
   • Niemelä M, Kuulasmaa K, for the MORGAM Project. Description and quality of baseline data: Cholesterol. (2007). Available from URL:http://www.ktl.fi/publications/morgam/qa/baseline/chol/cholqa.htm.
   • Niemelä M, Kulathinal S, Joseph B, Saarela O, Kuulasmaa K, for the MORGAM Project. Description and quality of baseline data: Height, weight, waist and hip measurements. (2007). Available from URL:http://www.ktl.fi/publications/morgam/qa/baseline/anthropm/anthropmqa.htm.
   • Kuulasmaa K, Niemelä M, Kulathinal S, for the MORGAM Project. Description and quality of baseline data: History of coronary heart disease, stroke and diabetes. (2007). Available from URL:http://www.ktl.fi/publications/morgam/qa/baseline/history/historyqa.htm.
   • Saarela O, and Kulathinal S, for the MORGAM Project. Description and quality of baseline data:
     Awareness and treatment of high blood pressure and cholesterol. (2008). Available from URL:http://www.ktl.fi/publications/morgam/qa/baseline/highbpchol/highbpcholqa.htm.
   • Veronesi G, Ferrario MM, Chambless LE, Niemelä M, Kuulasmaa K, for the MORGAM Project. Description and quality of baseline data: Marital status, education and occupation. (2008). Available from URL:http://www.ktl.fi/publications/morgam/qa/baseline/se_data/seqa.pdf.
   • Niemelä M, Kulathinal S, Joseph B, Saarela O, Kuulasmaa K, for the MORGAM Project. Follow-up data. (2007). Available from URL:http://www.ktl.fi/publications/morgam/qa/followup/followup.htm.

Relevant publications from individual MORGAM Centres

1. Evans A, Van Baal GC, McCarron P, DeLange M, Soerensen TI, de Geus EJ, Kyvik K, Pedersen NL, Spector TD, Andrew T, Patterson C, Whitfield JB, Zhu G, Martin NG, Kaprio J, Boomsma DI. The genetics of coronary heart disease: the contribution of twin studies. Twin Res. 2003;6: 432-41. [PubMed]
2. Harris JR, Willemsen G, Aitlahti T, Petrini C, Evans AE, Silander K, Cirrincione L, Kyvik KO. Ethical issues and GenomEUtwin. Twin Res. 2003;6:455-63. [PubMed]
3. Dolan C, O'Halloran A, Bradley DG, Croke DT, Evans A, O'Brien JK, Dicker P, Shields DC. Genetic stratification of pathogen-response-related and other variants within a homogeneous Caucasian Irish population. Eur J Hum Genet. 2005;13:798−806. [PubMed]
4. Auro K, Komulainen K, Alanne M, Silander K, Peltonen L, Perola M,  Salomaa V. Thrombomodulin gene polymorphisms and haplotypes and the risk of cardiovascular events: a prospective follow-up study. Arterioscler Thromb Vasc Biol.  2006;26:942-947. [PubMed]
5. Komulainen K, Alanne M, Auro K, Kilpikari R, Pajukanta P, Saarela J, Ellonen P, Salminen K, Kulathinal S, Kuulasmaa K, Silander K, Salomaa V, Perola M, Peltonen L. Risk alleles of USF1 -gene predict cardiovascular disease of women in two prospective studies. PLoS Genet 2006;2: e69. doi:10.1371/journal.pgen.002006 [PubMed]
6. Auro K, Alanne M, Kristiansson K, Silander K, Kuulasmaa K, Salomaa V, Peltonen L, Perola M. Combined effects of thrombosis pathway gene variants predict cardiovascular events. PLoS Genet. 2007;3:e120. doi:10.1371/journal.pgen.0030120 [PubMed]
7. Alanne M, Kristiansson K, Auro K, Silander K, Kuulasmaa K, Peltonen L, Salomaa V, Perola M. Variation in the selenoprotein S gene locus is associated with coronary heart disease and ischemic stroke in two independent Finnish cohorts. Hum Genet. 2007;122(3-4):355-65. [PubMed]
8. Silander K, Alanne M, Kristiansson K, Saarela O, Ripatti S, Auro K, Karvanen J, Kulathinal S, Niemelä M, Ellonen P, Vartiainen E, Jousilahti P, Saarela J, Kuulasmaa K, Evans A, Perola M, Salomaa V, Peltonen L: Gender differences in genetic risk profiles for cardiovascular disease. PLoS ONE. 2008;3:e3615. doi:10.1371/journal.pone.0003615 [Open access article]
9. Salomaa V, Havulinna AS, Saarela O, Zeller T, Jousilahti P, Jula A, Muenzel T, Aromaa A, Evans A, Kuulasmaa K, Blankenberg S. Thirty-one novel biomarkers as predictors for clinically incident diabetes. PLoS ONE. 2010;5:e10100. doi:10.1371/journal.pone.0010100 [Open access article]

© National Institute for Health and Welfare and the MORGAM Project investigators Last updated: 2 January 2012 (KK) For more information, please contact Kari Kuulasmaa (firstname.lastname@thl.fi)