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Research
Elevated plasma low density cholesterol (“bad” cholesterol, LDL) and reduced levels of high density cholesterol (“good” cholesterol, HDL) are important risk factors for cardiovascular disease (CVD). Intervention trials have demonstrated that lowering LDL-C levels will decrease CVD events. The ability of HDL to protect against the development of atherosclerotic coronary artery disease (CAD) has been well documented and although the exact molecular mechanism(s) behind this finding is still unsolved, it is thought to be due to their role in the reverse cholesterol transport. Recent research has greatly expanded our knowledge of the complex mechanisms involved in HDL metabolism. As they are clarified, investigators will be able to identify new targets for antiatherogenic treatments via specific drug design.
Current research interests
HDL-associated apolipoproteins; HDL-modifying lipolytic enzymes and lipid transfer proteins such as hepatic lipase (HL), lecithin-cholesterol acyltransferase (LCAT), cholesterol ester transfer protein (CETP) and phospholipid transfer protein (PLTP); intracellular and receptor proteins involved in HDL metabolism. Main emphasis of the group is on the role of PLTP in HDL metabolism and atherogenesis. Specific aims: i) expression of PLTP and its effect on lipoprotein metabolism, ii) biosynthesis and secretion of PLTP from hepatocytes and iii) elucidation of the physiological relevance of the active and inactive forms of PLTP in circulation. In addition, the group is investigating the effect of bacterial infection and lipid oxidation on lipoprotein metabolism and atherogenesis.
Research group
Matti Jauhiainen, Docent
Christian Ehnholm, Professor
Robert Badeau, M.Sc.
Jari Metso, M.Sc.
Mikko Muilu, M.Sc.
Sari Nuutinen, research assistant
Raija Pahlman, Ph.Lic.
Niko Setälä, M.D.
Riikka Vikstedt, M.Sc
Most important publications
- Kallio KA, Buhlin K, Jauhiainen M, Keva R, Tuomainen AM, Klinge B, Gustafsson A, Pussinen PJ. Lipopolysaccharide associates with pro-atherogenic lipoproteins in periodontitis patients.
Innate Immun. 2008 Aug; 14(4):247-53.
PubMed
- Badeau MH, Badeau R, Jauhiainen M, Tikkanen MJ. Steroid hormone-Fatty Acid Esters and Bone.
J Bone Miner Res., 2008 Jul 29.
PubMed
- Kumpula LS, Kumpula JM, Taskinen MR, Jauhiainen M, Kaski K, Ala-Korpela M. Reconsideration of hydrophobic lipid distributions in lipoprotein particles.
Chem Phys Lipids, 2008 Jun 20.
PubMed
- Mäkelä SM, Jauhiainen M, Ala-Korpela M, Metso J, Lehto TM, Savolainen MJ, Hannuksela ML. HDL
2 of heavy alcohol drinkers enhances cholesterol efflux from raw macrophages via phospholipid-rich HDL 2b particles.
Alcohol Clin Exp Res. 2008 Jun;32(6):991-1000.
PubMed
- Ahnström J, Axler O, Jauhiainen M, Salomaa V, Havulinna AS, Ehnholm C, Frikke-Schmidt R, Tybjaerg-Hansen A, Dahlbäck B. Levels of apolipoprotein M are not associated with the risk of coronary heart disease in two independent case-control studies.
J Lipid Res. 2008 May 19.
PubMed
- Lyly A, Marjavaara SK, Kyttälä A, Uusi-Rauva K, Luiro K, Kopra O, Martinez LO, Tanhuanpää K, Kalkkinen N, Suomalainen A, Jauhiainen M, Jalanko A. Deficiency of the INCL protein Pptl results in changes in ectopic FI-ATP synthase and altered cholesterol metabolism.
Hum Mol Genet. 2008 May 15;17(10):1406-17.
PubMed
- Christoffersen C, Jauhiainen M, Moser M, Porse B, Ehnholm C, Boesl M, Dahlbäck B, Nielsen LB. Effect of apolipoprotein M on high density lipoprotein metabolism and atherosclerosis in low density lipoprotein receptor knock-out mice.
J Biol Chem. 2008 Jan 25;
283(
4):
1839-47.
PubMed
- Badeau RM, Metso J, Tikkanen MJ, Jauhiainen M. High-density lipoprotein-associated 17beta-estradiol fatty acyl ester uptake by Fu5AH hepatoma cells: implications of the roles of scavenger receptor class B, type I and the low-density lipoprotein receptor.
Biochim Biophys Acta. 2007 Oct;
1771(
10):
1329-34.
PubMed
- Vikstedt R, Metso J, Hakala J, Olkkonen VM, Ehnholm C, Jauhiainen M. Cholesterol efflux from macrophage foam cells is enhanced by active phospholipid transfer protein through generation of two types of acceptor particles.
Biochemistry. 2007 Oct 23;
46(
42):
11979-86. Epub 2007 Sep 27.
PubMed
- Tuomainen AM, Jauhiainen M, Kovanen PT, Metso J, Paju S, Pussinen PJ. Aggregatibacter actinomycetemcomitans induces MMP-9 expression and proatherogenic lipoprotein profile in apoE-deficient mice. Microb Pathog.
2008 Feb;
44(
2):
111-7.
PubMed
- Moerland M, Samyn H, van Gent T, Jauhiainen M, Metso J, van Haperen R, Grosveld F, van Tol A, de Crom R. Atherogenic, enlarged, and dysfunctional HDL in human PLTP/apoA-I double transgenic mice.
J Lipid Res. 2007 Dec;
48(
12):
2622-31.
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PubMed
- Vikstedt R, Ye D, Metso J, Hildebrand RB, Van Berkel TJ, Ehnholm C, Jauhiainen M, Van Eck M. Macrophage Phospholipid Transfer Protein Contributes Significantly to Total Plasma Phospholipid Transfer Activity and Its Deficiency Leads to Diminished Atherosclerotic Lesion Development.
Arterioscler Thromb Vasc Biol. 2007 Mar;27(3):578-86.
PubMed
Ph.D. Dissertations
Terttu Tiirola -
Effects of Chlamydia Pneumoniae Infection on Imflammation and Lipid Parameters in Human and Mice. Publication of the National Public Health Institute, University of Oulu, 2006. (Supervised by Adjunct Professor Matti Jauhiainen, Research Professor Maija Leinonen and Emeritus Professor Pekka Saikku)
Minna T. Jänis -
The High- and Low-activity Forms of Human Plasma Phospholipid Transfer Protein (PLTP). Publication of the National Public Health Institute, University of Helsinki, 2006. (Supervised by Adjunct Professor Matti Jauhiainen, Adjunct Professor Vesa Olkkonen and Research Professor Christian Ehnholm)
Sarah Siggins -
Plasma Phospholipid Transfer Protein (PLTP): Quantitation, Biosynthesis, and Involvement in Hepatic Lipid Homeostasis. Publication of the National Public Health Institute, University of Helsinki, 2005. (Supervised by Docent Vesa Olkkonen, Docent Matti Jauhiainen and Professor Christian Ehnholm)
Anna Illike Höckerstedt -
Estradiol Fatty Acid Esterification In High Density Lipoprotein. University of Helsinki, 2004. (Supervised by Professor Matti Tikkanen and Docent Matti Jauhiainen)
Sonja Jaari - Proteins Involved In High Density Lipoprotein Metabolism - A Special Reference To Apolipoprotein A-I, Hepatic Lipase And Phospholipid Transfer Protein. Publication of the National Public Health Institute, University of Helsinki, 2002. (Supervised by Docent Matti Jauhiainen and Docent Vesa Olkkonen)
Jarkko Huuskonen - The Phospholipid Transfer Activity And Structural Features Of Human Plasma PLTP. Publication of the National Public Health Institute, University of Helsinki, 1999. (Supervised by Docent Vesa Olkkonen and Docent Matti Jauhiainen)
Pirkko Pussinen - Plasma Phospholipid Transfer Protein (PLTP) In High Density Lipoprotein (HDL) Metabolism. Publication of the National Public Health Institute, University of Helsinki, 1997. (Supervised by Professor Christian Ehnholm and Docent Matti Jauhiainen)
Mari Kuronen - Lipoprotein(a) - Studies On The Protease Region And Assay Methology. University of Kuopio, 1996. (Supervised by Professor Christian Ehnholm, Docent Matti Jauhiainen and Professor Terho Eloranta)
Liisa M. Valsta - Effects Of Rapeseed Oil On Serum Lipoproteins And Plasma Fatty Acids - Comparsion Of Strictly And Partially Controlled Human Dietary Interventions. Publication of the National Public Health Institute, University of Helsinki, 1995. (Supervised by Professor Leena Räsänen and Docent Matti Jauhiainen)
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Additional information
Docent Matti Jauhiainen
e-mail: firstname.lastname@thl.fi
Links:
International Atherosclerosis Society
European Atherosclerosis Society
European Lipoprotein Club
Scandinavian Society for Atherosclerosis Research
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