Publication Catalogue

Publications of the Department of Molecular Medicine 2001

A. Original articles and reviews

  1. Aalto-Setälä K, Laitinen K, Erkkilä L, Leinonen M, Jauhiainen M, Ehnholm C, Tamminen M, Puolakkainen M, Penttilä I, Saikku P: Chlamydia pneumoniae does not increase atherosclerosis in the aortic root of apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 2001;21:578-584.
  2. Auranen M, Ala-Mello S, Turunen J, Järvelä I: Further evidence for linkage to 1q in autosomal dominant medullary cystic kidney disease in Finnish families. Kidney Int 2001;60:1225-1232.
  3. Auranen M, Vanhala R, Vosman M, Levander M, Varilo T, Hietala M, Riikonen R, Peltonen L, Järvelä I: MECP2 gene analysis in classical Rett syndrome and in patients with Rett-like features. Neurology 2001;56:611-617.
  4. Barlage S, Fröhlich D, Böttcher A, Jauhiainen M, Müller HP, Noetzel F, Rothe G, Schütt C, Linke RP, Lackner KJ, Ehnholm C, Schmitz G: ApoE-containing high density lipoproteins and phospholipid transfer protein activity increase in patients with a systemic inflammatory response. J Lipid Res 2001;42:281-290.
  5. Blom TS, Koivusalo M, Kuismanen E, Kostiainen R, Somerharju P, Ikonen E: Mass spectrometric analysis reveals an increase in plasma membrane polyansaturated phospholipid species upon cellular cholesterol loading. Biochemistry 2001(40):14653-14644.
  6. Blom TS, Koivusalo M, Kuismanen E, Kostiainen R, Somerharju P, Ikonen E: Mass spectrometric analysis reveals an increase in plasma membrane polyunsaturated phospholipid species upon cellular cholesterol loading. Biochemistry 2001;40:14635-14644.
  7. Diabetes Atherosclerosis Intervention Study Investigators, Ehnholm C: Effect of fenofibrate on progression of coronary-artery disease in type 2 diabetes: the Diabetes Atherosclerosis Intervention Study, a randomised study. Lancet 2001;357:905-910.
  8. Douglas JA, Erdos MR, Watanabe RM, Braun A, Johnston CL, Oeth P, Mohlke KL, Valle TT, Ehnholm C, Buchanan TA, Bergman RN, Collins FS, Boehnke M, Tuomilehto J: The peroxisome poliferator-activated receptor-y2 pro12A1a variant. Diabetes 2001;50:886-890.
  9. Ekelund J, Hovatta I, Parker A, Paunio T, Varilo T, Martin R, Suhonen J, Ellonen P, Chan G, Sinsheimer JS, Sobel E, Juvonen H, Arajärvi R, Partonen T, Suvisaari J, Lönnqvist J, Meyer J, Peltonen L: Chromosome 1 loci in Finnish schizophrenia families. Hum Mol Genet 2001;10:1611-1617.
  10. Ekelund J, Suhonen J, Järvelin M, Peltonen L, Lichtermann D: No association of the -521 C/T polymorphism in the promoter of DRD4 with novelty seeking. Molecular psychiatry 2001;6:618-619.
  11. Feng J, Yan J, Michaud S, Craddock N, Jones IR, Cook EH, Goldman D, Heston LL, Peltonen L, Delisi LE, Sommer SS: Scanning of estrogen receptor a and thyroid hormone receptor a genes in patients with psychiatric diseases. Am J Med Genet 2001(105):369-374.
  12. Gong Y, Slee R, Fukai N, Rawadi G, Roman-Roman S, Reginato AM, Wang H, Cundy T, Glorieux FH, Lev D, Zacharin M, Oexle K, Marcelino J, Suwairi W, Heeger S, Sabatakos G, Apte S, Adkins WN, Allgrove J, Arslan-Kirchner M, Batch JA, Bieghton P, Black B, Boles RG, Boon LM, Borrone C, Brunner HG, Carle GF, Dallapiccola B, de Paepe A, Floege B, Lees HM, Hall B, Hennekam RC, Hirose T, Jans A, Jüppner H, Ae KC, Keppler-Noreuil K, Kohlschuetter A, LaCombe D, Lambert M, Lemyre E, Letteboer T, Peltonen L, Ramesar RS, Romanengo M, Somer H, Steichen-Gersdorf E, Steinmann B, Sullivan B, Superti-Furga A, Swoboda W, van den Boogaard M, Van Hul W, Vikkula M, Votruba M, Zabel B, Garcia T, Baron R, Olsen BR, Warman ML: LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell 2001(107):513-523.
  13. Gotto AM, Ehnholm C: Low high-density lipoprotein cholesterol as a risk factor in coronary heart disease. A working group report. Circulation 2001;103:2213-2218.
  14. Halminen M, Juhela S, Vaarala O, Simell O, Ilonen J: Induction of interferon-gamma and IL-4 production by mitogen and specific antigens in peripheral blood lymphocytes of Type 1 diabetes patients. AUTOIMMUNITY 2001;34:1-8.
  15. Halonen M, Pelto-Huikko M, Eskelin P, Peltonen L, Ulmanen I, Kolmer M: Subcellular location and expression pattern of autoimmune regulator (Aire), the mouse ortholog for human gene defective in Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (APECED). J Histochem Cytochem 2001;49:197-208.
  16. Haravuori H, Vihola A, Staub V, Auranen M, Richard S, Marchand T, Voit T, Labeit S, Somer H, Peltonen L, Beckmann JS, Udd B: Secondary calpain3 deficiency in 2q-linked muscular dystrophy: Titin is the candidate gene. Neurology 2001;56:869-877.
  17. Haukka J, Suvisaari J, Varilo T, Lönnqvist J: Regional variation in the incidence of schizophrenia in Finland: a study of birth cohorts born from 1950 to 1969. Psychol Med 2001(31):1045-1053.
  18. Helisten H, Höckerstedt A, Wähälä K, Tiitinen A, Adlercreutz H, Jauhiainen M, Tikkanen MJ: Accumulation of high-density lipoprotein-derived estradiol-17B fatty acid esters in low-density lipoprotein particles. J Clin Endocrinol Metab 2001;86:1294-1300.
  19. Holopainen J, Saarikoski J, Kinnunen P, Järvelä I: Elevated lysosomal pH in neuronal ceroid lipofuscinoses (NCLs). Eur J Biochem 2001;268:5851-5856.
  20. Huuskonen J, Olkkonen VM, Juahiainen M, Ehnholm C: The impact of phospholipid transfer protein (PLTP) on HDL metabolism. Atherosclerosis 2001(155):269-281.
  21. Huuskonen J, Olkkonen VM, Jauhiainen M, Ehnholm C: The impact of phospholipid transfer protein (PLTP) on HDL metabolism. Atherosclerosis 2001;155:269-281.
  22. Ikonen E: Roles of lipid rafts in membrane transport. CURR OPIN CELL BIOL 2001;13:470-477.
  23. Jaari S, van Dijk KW, Olkkonen VM, van der Zee A, Metso J, Havekes L, Jauhiainen M, Ehnholm C: Dynamic changes in mouse lipoproteins induced by transiently expressed human phospholipid transfer protein (PLTP): importance of PLTP in prebeta-HDL generation. Comp Biochem Physiol Biochem Mol Biol 2001;128:781-792.
  24. Jansen H, Waterworth DM, Nicaud V, Ehnholm C, Talmud PJ: Interaction of the common apolipoprotein C-III (APOC3 -482C > T) and hepatic lipase (LIPC -514C > T) promoter variants affects glucose tolerance in young adults. European Atherosclerosis Research Study II (EARS-II). ANN HUM GENET 2001;65:237-243.
  25. Kajander OA, Kupari M, Perola M, Pajarinen J, Savolainen V, Penttilä A, Karhunen PJ: Testing genetic susceptibility loci for alcoholic heart muscle disease. Alcohol Clin Exp Res 2001;25:1409-1413.
  26. Kervinen H, Palosuo T, Manninen V, Tenkanen L, Vaarala O, Mänttäri M: Joint effects of C-reactive protein and other risk factors on acute coronary events. AM HEART J 2001;141:580-585.
  27. Keso T, Perola M, Laippala P, Ilveskoski E, Kunnas TA, Mikkelsson J, Penttilä A, Hurme M, Karhunen PJ: Polymorphsims within the tumor necrosis factor locus and prevance of coronary artery disease in middle-aged men. Atherosclerosis 2001;154:691-697.
  28. Korpinen E, Groop PH, Fagerudd JA, Teppo A, Âkerblom HK, Vaarala O: Increased secretion of TGF-beta1 by peripheral blood mononuclear cells from patients with Type 1 diabetes mellitus with diabetic nephropathy. Diabet Med 2001;18:121-125.
  29. Lautala P, Ulmanen I, Taskinen J: Molecular Mechanisms controlling the rate and specificity of catechol O-methylation by human soluble catechol O-methyltransferase. MOL PHARMACOL 2001;59:393-402.
  30. Lee MS, Lyoo CH, Ulmanen I, Syvänen AC, Rinne JO: Genotypes of catechol-O-methyltransferase and response to levodopa treatment in patients with Parkinson's disease. NEUROSCI LETT 2001;298:131-134.
  31. Lehto M, Laitinen S, Chinetti G, Johansson M, Ehnholm C, Staels B, Ikonen E, Olkkonen VM: The OSBP-related protein family in humans. J Lipid Res 2001(42):1203-1213.
  32. Lehto M, Laitinen S, Chinetti G, Johansson M, Ehnholm C, Staels B, Ikonen E, Olkkonen VM: The OSBP-related protein family in humans. J Lipid Res 2001;42:1203-1213.
  33. Lehtovirta M, Kyttälä A, Eskelinen E, Hess M, Heinonen O, Jalanko A: Palmitoyl protein thioesterase (PPT) localizes into synaptosomes and synaptic vesicles in neurons: implications for infantile neuronal ceroid lipofuscinosis (INCL). Hum Mol Genet 2001;10:69-75.
  34. Lichtenstein AH, Jauhiainen M, McGladdery S, Ausman LM, Jalbert SM, Vilella-Bach M, Ehnholm C, Frohlich J, Schaefer EJ: Impact of hydrogenated fat on high density lipoprotein subfractions and metabolism. J Lipid Res 2001;42:597-604.
  35. Lie J, de Crom R, Jauhiainen M, van Gent T, van Haperen R, Scheek L, Jansen H, Ehnholm C, van Tol A: Evaluation of phospholipid transfer protein and cholesteryl ester transfer protein as contributors to the generation of pre beta-high-density lipoproteins. Biochem J 2001;360:379-385.
  36. Luiro K, Kopra O, Lehtovirta M, Jalanko A: CLN3 protein is targeted to neuronal synapses but excluded from synaptic vesicles: new clues to Batten disease. Hum Mol Genet 2001;10:2123-2131.
  37. Lusa S, Blom TS, Eskelinen EL, Kuismanen E, Mansson JE, Simons K, Ikonen E: Depletion of rafts in late endocytic membranes is controlled by NPC1-dependent recycling of cholesterol to the plasma membrane. J Cell Sci 2001(114):1893-1900.
  38. Lusa S, Blom TS, Eskelinen EL, Kuismanen E, Mansson JE, Simons K, Ikonen E: Depletion of rafts in late endocytic membranes is controlled by NPC1-dependent recycling of cholesterol to the plasma membrane. J Cell Sci 2001;114:1893-1900.
  39. Marttila J, Juhela S, Vaarala O, Hyöty H, Roivainen M, Hinkkanen A, Vilja P, Simell O, Ilonen J: Responses of coxsackievirus B4-specific T-cell lines to 2C protein - characterization of epitopes with special reference to the GAD65 homology region. Virology 2001;284:131-141.
  40. Matthan NR, Cianflone K, Lichtenstein AH, Ausman LM, Jauhiainen M, Jones PJ: Hydrogenated fat consumption affects acylation-stimulating protein levels and cholesterol esterification rates in moderately hypercholesterolemic women. J Lipid Res 2001;42:1841-1848.
  41. Meriluoto T, Halonen M, Pelto-Huikko M, Kangas H, Korhonen J, Kolmer M, Ulmanen I, Eskelin P: The autoimmune regulator: a key toward understanding the molecular pathogenesis of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. KEIO J MED 2001;50:225-239.
  42. Mikkelsson J, Perola M, Penttilä A, Goldschmidt-Clermont PJ, Karhunen PJ: The GPIIIa (beta3 integrin) P1A polymorphism in the early development of coronary atherosclerosis. Atherosclerosis 2001;154:721-727.
  43. Myhre AG, Halonen M, Eskelin P, Ekwall O, Hedstrand H, Rorsman F, kampe O, Husebye ES: Autoimmune polyendocrine syndrome type 1 (APS I) in Norway. CLIN ENDOCRINOL (OXF) 2001;54:211-217.
  44. Mänttäri M, Manninen V, Palosuo T, Ehnholm C: Apolipoprotein E polymorphism and C-reactive protein in dyslipidemic middle-aged men. Atherosclerosis 2001;156:237-238.
  45. Ogorelkova M, Kraft HG, Ehnholm C, Utermann G: Single nucleotide polymorphisms in exons of the apo(a) kringles IV types 6 to 10 domain affect Lp(a) plasma concentrations and have different patterns in Africans and Caucasians. Hum Mol Genet 2001;10:815-824.
  46. Pajukanta P, Bodnar J, Sallinen R, Chu M, Xiao Q, Airaksinen T, Castellani L, Wessman M, Palotie A, Sinsheimer J, Demant P, Lusis A, Peltonen L: Fine mapping of the human familial combined hyperlipidemia locus on chromosome 1q21-q23 using conserved synteny to the mouse locus on chromosome 3. MAMM GENOME 2001;12:238-245.
  47. Pastinen T, Perola M, Ignatius J, Sabatti C, Tainola P, Levander M, Syvänen AC, Peltonen L: Dissecting a population genome for targeted screening of disease mutations. Hum Mol Genet 2001;10:2961-2972.
  48. Paunio T, Ekelund J, Varilo T, Parker A, Hovatta I, Turunen JA, Rinard K, Foti A, Terwilliger JD, Juvonen H, Suvisaari J, Arajärvi R, Suokas J, Partonen T, Lönnqvist J, Meyer J, Peltonen L: Genome-wide scan in a nationwide study sample of schizophrenia families in Finland reveals susceptibility loci on chromosomes 2q and 5q. Hum Mol Genet 2001;10:3037-3048.
  49. Perola M, Öhman M, Hiekkalinna T, Leppävuori J, Pajukanta P, Wessman M, Koskenvuo M, Palotie A, Lange K, Kaprio J, Peltonen L: Quantitative-Trait-Locus analysis of body-mass index and of stature, by combined analysis of genome scans of five Finnish study groups. Am J Hum Genet 2001;69:117-123.
  50. Pirinen S, Kentala A, Nieminen P, Varilo T, Thesleff I, Arte S: Recessively inherited lower incisor hypodontia. J Med Genet 2001;38:551-556.
  51. Pol A, Luettersforst R, Lindsay M, Heino S, Ikonen E, Parton RG: A caveolin dominant negative mutant associates with lipid bodies and induces intracellular cholesterol imbalance. J Cell Biol 2001;152:1057-1070.
  52. Pussinen PJ, Malle E, Metso J, Sattler W, Raynes JG, Jauhiainen M: Acute-phase HDL in phospholipid transfer protein (PLTP)-mediated HDL conversion. Atherosclerosis 2001;155:297-305.
  53. Pussinen PJ, Metso J, Malle E, Barlage S, Palosuo T, Sattler W, Schmitz G, Jauhiainen M: The role of plasma phospholipid transfer protein (PLTP) in HDL remodeling in acute-phase patients. Biochim Biophys Acta 2001;1533:153-163.
  54. Puurunen M, Palosuo T, Lassila R, Anttila M, Vaarala O: Immunologic and hematologic properties of antibodies to prothrombin and plasminogen in a mouse model. LUPUS 2001;10:108-115.
  55. Pöllänen PJ, Karhunen PJ, Mikkelsson J, Laippala P, Perola M, Penttilä A, Mattila KM, Koivula T, Lehtimäki T: Coronary artery complicated lesion area is related to functional polymorphism of matrix metalloproteinase 9 gene: an autopsy study. Arterioscler Thromb Vasc Biol 2001;21:1446-1450.
  56. Saarela J, Laine M, Oinonen C, von Schantz C, Jalanko A, Rouvinen J, Peltonen L: Molecular pathogenesis of a disease: structural consequences of aspartylglucosaminuria mutations. Hum Mol Genet 2001;10:983-995.
  57. Salonen T, Heinonen-Kopra O, Vesa J, Jalanko A: Neuronal trafficking of palmitoyl protein thioesterase provides an excellent model to study the effects of different mutations which cause infantile neuronal ceroid lipofuscinosis . MOL CELL NEUROSCI 2001;18:131-140.
  58. Settasatian N, Duong M, Curtiss LK, Ehnholm C, Jauhiainen M, Huuskonen J, Rye KA: The mechanism of the remodeling of high density lipoproteins by phospholipid transfer protein. J Biol Chem 2001;276:26898-26905.
  59. Srinivasan SR, Ehnholm C, Elkasabany A, Berenson GS: Apolipoprotein E polymorphism modulates the association between obesity and dyslipidemias during young adulthood: The Bogalusa Heart Study. Metabolism 2001;50:696-702.
  60. Stengârd JH, Salomaa V, Rasi V, Vahtera E, Ehnholm C, Krusius T, Perola M, Vartiainen E: Utility of the Arg/Gln polymorphism of the factor VII (FVII) gene, serum lipid levels and body mass index in the prediction of the FVII:C and FVII:Ag in North Karelia; a cross-sectional and prospective study. BLOOD COAGUL FIBRINOLYSIS 2001;12:445-452.
  61. Stenmark H, Olkkonen VM: The Rab GTPase family. Genome Biology 2001(2):3007.1-3007.7.
  62. Stenmark H, Olkkonen VM: The Rab GTPase family. Genome Biology 2001;2:REVIEWS3.
  63. Syvänne M, Pajunen P, Kahri J, Lahdenperä S, Ehnholm C, Nieminen MS, Taskinen MR: Determinants of the severity and extent of coronary artery disease in patients with type-2 diabetes and in nondiabetic subjects. Coron Artery Dis 2001;12:99-106.
  64. Videman T, Gibbons L, Battié M, Maravilla K, Vanninen E, Leppävuori J, Kaprio J, Peltonen L: The relative roles of intragenic polymorphisms of the vitamin D receptor gene in lumbar spine degeneration and bone density. Spine 2001;26:7-12.

C. Textbooks and chapters in textbooks, reports and proceedings

  1. Palotie L: Suomalaiset tautigeenit kertovat väestön historiasta. Keuruu: Otava, 2001. 270-271 p. (Mitä-Missä-Milloin 2001/2001).
  2. Sherer Y, Blank M, Vaarala O, Shaish A, Shoenfeld Y, Harats D: Anti-prothrombin antibodies in thrombosis and atherosclerosis. In: Shoenfeld Y, Harats D, Wick G ed. Atherosclerosis and autoimmunity. 2001:185-190.
  3. Tikkanen MJ, Helisten H, Höckerstedt A, Wähälä K, Tiitinen A, Adlercreutz H, Jauhiainen M: Lipoprotein-associated estrogen: the role of lecithin: cholesterol acyltransferase and cholesteryl ester transfer protein. In: Genazzani AR ed. Hormone replacement therapy and cardiovascular disease. Carnforth: The Parthenon Publishing Group Limited, 2001:127-131. (Controversial issues in climacteric medicine series).
  4. Vaarala O: Immunology of atherosclerosis. In: Asherson RA, Cervera R ed. Vascular manifestations of systemic autoimmune diseases. Boca Raton: CRC Press LLC, 2001:61-70.
  5. Vaarala O: SLE as a model of autoimmune atherosclerosis. In: Shoenfeld Y, Harats D, Wick G ed. Atherosclerosis and autoimmunity. 2001:267-272.

E. Theses

  1. Ekelund J: Molecular genetics of schizophrenia and comorbid and related traits [dissertation]. Cosmoprint Oyj, Helsinki: National Public Health Institute , 2001. (A17/2001).
  2. Paronen J: Dietary insulin and the gut immune system in type 1 diabetes. Helsinki: Yliopistopaino, 2001. (Publications of the National Public Health Institute A 4/2001/2001).
  3. Salonen T: Molecular and cellular biology of infantile neuronal ceroid lipofuscinosis. Cosmoprint, Helsinki: National Public Health Institute A3/2001, 2001.
  4. Öhman M: The Search for genes predisposing to obesity. Yliopistopaino, Helsinki: National Public Health Institute A3/2001, 2001.