Pharmacological treatment during AMI and in secondary prevention: the scientific evidence

Table 13. Antioxidants. Effect on mortality
STUDIES DRUGS No. PATIENTS FOLLOW-UP VAR. P
After infarction
CHAOS (1996) [89] VIT. E
800 mg/400 mg		 2,002 1.5 YEARS --
(-77%)*		 --
(0.005)*
ATBC (1997) [77] BETACAROTENE
20 mg		 1,862 5.3 YEARS +75% 0.007
VIT. E 50 mg 1,862 5.3 YEARS +33% 0.20

* non fatal myocardial infarctions

ACC/AHA GUIDELINES

  • There are insufficient data either in favour or against the use of water or fat soluble antioxidants in the post-infarct period

ANMCO-SIC CLINICAL GUIDELINES