Index

Hardy-Weinberg equilibrium tests in the subcohort for SNPs of the 5Q21_1 gene:

  1. 5Q21_1_MG_435 (rs436495)
  2. 5Q21_1_MG_436 (rs449650)
  3. 5Q21_1_MG_441 (rs565928)
  4. 5Q21_1_MG_455 (rs383830)

5Q21_1_MG_435  (rs436495)

RUA cohort N N
miss		 Allele
frequencies		 Genotype distribution p-value
G/G G/A A/A
G A O E O E O E
FIN-ATB 21 1037 13 1534 514 576 575 382 385 66 65 0.868
FIN-FIN 03 434 11 657 189 256 255 145 147 22 21 0.781
24 466 6 701 219 277 267 147 167 36 26 0.010
Total 900 17 1358 408 533 522 292 314 58 47 0.046
FRA-PRI 21 170 8 263 61 110 107 43 50 9 6 0.073
SWE-NSW 02 77 0 115 39 42 43 31 29 4 5 0.565
03 89 1 134 42 51 51 32 32 5 5 1.000
Total 166 1 249 81 93 94 63 61 9 10 0.682
UNK-BEL 21 145 2 227 59 90 90 47 47 6 6 1.000
Total 2418 41 3631 1123 1402 1387 827 858 148 133 0.078

5Q21_1_MG_436  (rs449650)

RUA cohort N N
miss		 Allele
frequencies		 Genotype distribution p-value
G/G G/T T/T
G T O E O E O E
FIN-ATB 21 1037 11 1589 463 620 615 349 359 57 52 0.372
FIN-FIN 03 434 5 700 158 292 286 116 129 21 15 0.052
24 466 5 722 200 293 283 136 157 32 22 0.006
Total 900 10 1422 358 585 568 252 286 53 36 <0.001
FRA-PRI 21 170 10 263 57 111 108 41 47 8 5 0.110
SWE-NSW 02 77 0 115 39 42 43 31 29 4 5 0.566
03 89 1 135 41 52 52 31 31 5 5 1.000
Total 166 1 250 80 94 95 62 61 9 10 0.836
UNK-BEL 21 145 3 227 57 91 91 45 46 6 6 1.000
Total 2418 35 3751 1015 1501 1476 749 799 133 108 0.002

5Q21_1_MG_441  (rs565928)

RUA cohort N N
miss		 Allele
frequencies		 Genotype distribution p-value
C/C C/T T/T
C T O E O E O E
FIN-ATB 21 1037 11 1592 460 622 618 348 357 56 52 0.476
FIN-FIN 03 434 2 704 160 293 287 118 130 21 15 0.056
24 466 5 722 200 293 283 136 157 32 22 0.006
Total 900 7 1426 360 586 569 254 287 53 36 <0.001
FRA-PRI 21 170 5 267 63 110 108 47 51 8 6 0.330
SWE-NSW 02 77 0 115 39 42 43 31 29 4 5 0.567
03 89 1 135 41 52 52 31 31 5 5 1.000
Total 166 1 250 80 94 95 62 61 9 10 0.834
UNK-BEL 21 145 2 227 59 90 90 47 47 6 6 1.000
Total 2418 26 3762 1022 1502 1479 758 804 132 109 0.006

5Q21_1_MG_455  (rs383830)

RUA cohort N N
miss		 Allele
frequencies		 Genotype distribution p-value
T/T T/A A/A
T A O E O E O E
FIN-ATB 21 1036 8 1592 464 621 616 350 359 57 52 0.421
FIN-FIN 03 434 4 700 160 291 285 118 130 21 15 0.057
24 466 5 723 199 294 283 135 156 32 21 0.004
Total 900 9 1423 359 585 568 253 287 53 36 <0.001
FRA-PRI 21 170 11 260 58 109 106 42 47 8 5 0.183
SWE-NSW 02 77 0 115 39 42 43 31 29 4 5 0.564
03 89 2 135 39 52 52 31 30 4 4 1.000
Total 166 2 250 78 94 95 62 59 8 9 0.673
UNK-BEL 21 145 3 228 56 91 92 46 45 5 6 0.803
Total 2417 33 3753 1015 1500 1477 753 799 131 108 0.005

O:Observed number of the specific genotype
E:Expected number of the specific genotype
npc:Not possible to calculate due to non-occurrence of some alleles
Updated on 2008-12-08