Index

Hardy-Weinberg equilibrium tests in the subcohort for SNPs of the 9P21_3 gene:

  1. 9P21_3_MG_420 (rs10738610)
  2. 9P21_3_MG_421 (rs10757283)
  3. 9P21_3_MG_425 (rs1333049)
  4. 9P21_3_MG_437 (rs496892)
  5. 9P21_3_MG_451 (rs1537378)
  6. 9P21_3_MG_459 (rs7865618)

9P21_3_MG_420  (rs10738610)

RUA cohort N N
miss		 Allele
frequencies		 Genotype distribution p-value
A/A A/C C/C
A C O E O E O E
FIN-ATB 21 1037 16 1203 839 351 354 501 494 169 172 0.650
FIN-FIN 03 434 4 522 338 164 158 194 205 72 66 0.265
24 466 6 551 369 161 165 229 221 70 74 0.434
Total 900 10 1073 707 325 323 423 426 142 140 0.833
FRA-PRI 21 170 4 168 164 41 43 86 83 39 41 0.644
SWE-NSW 02 77 0 80 74 17 21 46 38 14 18 0.110
03 89 1 101 75 32 29 37 43 19 16 0.193
Total 166 1 181 149 49 50 83 82 33 34 0.875
UNK-BEL 21 145 3 136 148 34 33 68 71 40 39 0.736
Total 2418 34 2761 2007 800 799 1161 1162 423 422 0.966

9P21_3_MG_421  (rs10757283)

RUA cohort N N
miss		 Allele
frequencies		 Genotype distribution p-value
C/C C/T T/T
C T O E O E O E
FIN-ATB 21 1037 11 1105 947 293 298 519 510 214 219 0.574
FIN-FIN 03 434 8 448 404 123 118 202 212 101 96 0.333
24 466 5 475 447 121 122 233 230 107 108 0.781
Total 900 13 923 851 244 240 435 443 208 204 0.590
FRA-PRI 21 170 3 194 140 54 56 86 81 27 29 0.525
SWE-NSW 02 77 0 80 74 15 21 50 38 12 18 0.012
03 89 1 108 68 30 33 48 42 10 13 0.184
Total 166 1 188 142 45 54 98 81 22 31 0.008
UNK-BEL 21 145 2 177 109 59 55 59 67 25 21 0.110
Total 2418 30 2587 2189 695 701 1197 1186 496 502 0.649

9P21_3_MG_425  (rs1333049)

RUA cohort N N
miss		 Allele
frequencies		 Genotype distribution p-value
G/G G/C C/C
G C O E O E O E
FIN-ATB 21 1037 9 1222 834 360 363 502 496 166 169 0.698
FIN-FIN 03 434 2 527 337 168 161 191 206 73 66 0.131
24 466 5 554 368 163 166 228 221 70 73 0.562
Total 900 7 1081 705 331 327 419 427 143 139 0.578
FRA-PRI 21 170 3 177 157 46 47 85 83 36 37 0.758
SWE-NSW 02 77 0 86 68 22 24 42 38 13 15 0.371
03 89 1 107 69 35 33 37 42 16 14 0.266
Total 166 1 193 137 57 56 79 80 29 28 0.873
UNK-BEL 21 145 2 137 149 33 33 71 71 39 39 1.000
Total 2418 22 2810 1982 827 824 1156 1162 413 410 0.802

9P21_3_MG_437  (rs496892)

RUA cohort N N
miss		 Allele
frequencies		 Genotype distribution p-value
C/C C/T T/T
C T O E O E O E
FIN-ATB 21 1037 10 1062 992 276 275 510 513 241 240 0.901
FIN-FIN 03 434 18 399 433 84 96 231 208 101 113 0.023
24 466 5 469 453 118 119 233 230 110 111 0.782
Total 900 23 868 886 202 215 464 438 211 224 0.090
FRA-PRI 21 170 3 178 156 48 47 82 83 37 36 0.878
SWE-NSW 02 77 0 75 79 17 18 41 38 19 20 0.651
03 89 1 74 102 17 16 40 43 31 30 0.662
Total 166 1 149 181 34 34 81 82 50 50 1.000
UNK-BEL 21 145 2 146 140 34 37 78 71 31 34 0.316
Total 2418 39 2403 2355 594 607 1215 1189 570 583 0.285

9P21_3_MG_451  (rs1537378)

RUA cohort N N
miss		 Allele
frequencies		 Genotype distribution p-value
G/G G/A A/A
G A O E O E O E
FIN-ATB 21 1036 9 1238 816 357 373 524 492 146 162 0.038
FIN-FIN 03 434 23 513 309 158 160 197 193 56 58 0.674
24 466 5 578 344 180 181 218 216 63 64 0.841
Total 900 28 1091 653 338 341 415 408 119 122 0.663
FRA-PRI 21 170 13 188 126 62 56 64 75 31 25 0.069
SWE-NSW 02 77 0 96 58 30 30 36 36 11 11 1.000
03 89 2 91 83 28 24 35 43 24 20 0.086
Total 166 2 187 141 58 53 71 80 35 30 0.153
UNK-BEL 21 145 7 164 112 47 49 70 67 21 23 0.602
Total 2417 59 2868 1848 862 872 1144 1124 352 362 0.388

9P21_3_MG_459  (rs7865618)

RUA cohort N N
miss		 Allele
frequencies		 Genotype distribution p-value
A/A A/G G/G
A G O E O E O E
FIN-ATB 21 1036 11 1176 874 336 337 504 501 185 186 0.899
FIN-FIN 03 434 4 482 378 135 135 212 212 83 83 1.000
24 466 6 531 389 159 153 213 225 88 82 0.250
Total 900 10 1013 767 294 288 425 437 171 165 0.411
FRA-PRI 21 170 11 184 134 57 53 70 78 32 28 0.258
SWE-NSW 02 77 0 87 67 24 25 39 38 14 15 0.817
03 89 2 86 88 22 21 42 43 23 22 0.832
Total 166 2 173 155 46 46 81 82 37 37 0.876
UNK-BEL 21 145 5 159 121 40 45 79 69 21 26 0.084
Total 2417 39 2705 2051 773 769 1159 1167 446 442 0.739

O:Observed number of the specific genotype
E:Expected number of the specific genotype
npc:Not possible to calculate due to non-occurrence of some alleles
Updated on 2008-12-08