Index

Hardy-Weinberg equilibrium tests in the subcohort for SNPs of the MTHFD1L gene:

  1. MTHFD1L_MG_423 (rs12525353)
  2. MTHFD1L_MG_445 (rs6922269)
  3. MTHFD1L_MG_449 (rs12214306)

MTHFD1L_MG_423  (rs12525353)

RUA cohort N N
miss		 Allele
frequencies		 Genotype distribution p-value
C/C C/A A/A
C A O E O E O E
FIN-ATB 21 1037 10 2018 36 993 991 32 35 2 0 0.038
FIN-FIN 03 434 4 840 20 410 410 20 20 0 0 1.000
24 466 6 901 19 441 441 19 19 0 0 1.000
Total 900 10 1741 39 851 851 39 38 0 0 1.000
FRA-PRI 21 170 3 327 7 160 160 7 7 0 0 1.000
SWE-NSW 02 77 0 152 2 75 75 2 2 0 0 1.000
03 89 1 172 4 84 84 4 4 0 0 1.000
Total 166 1 324 6 159 159 6 6 0 0 1.000
UNK-BEL 21 145 2 279 7 136 136 7 7 0 0 1.000
Total 2418 26 4689 95 2299 2298 91 93 2 1 0.070

MTHFD1L_MG_445  (rs6922269)

RUA cohort N N
miss		 Allele
frequencies		 Genotype distribution p-value
G/G G/A A/A
G A O E O E O E
FIN-ATB 21 1037 11 1580 472 607 608 366 363 53 54 0.862
FIN-FIN 03 434 4 686 174 276 274 134 139 20 18 0.549
24 466 5 719 203 275 280 169 158 17 22 0.176
Total 900 9 1405 377 551 554 303 297 37 40 0.615
FRA-PRI 21 170 5 235 95 87 84 61 68 17 14 0.186
SWE-NSW 02 77 0 116 38 43 44 30 29 4 5 0.766
03 89 1 134 42 51 51 32 32 5 5 1.000
Total 166 1 250 80 94 95 62 61 9 10 0.836
UNK-BEL 21 145 3 206 78 75 75 56 57 11 11 1.000
Total 2418 29 3676 1102 1414 1414 848 848 127 127 1.000

MTHFD1L_MG_449  (rs12214306)

RUA cohort N N
miss		 Allele
frequencies		 Genotype distribution p-value
T/T T/C C/C
T C O E O E O E
FIN-ATB 21 1036 7 2002 56 973 974 56 54 0 1 0.630
FIN-FIN 03 434 4 839 21 409 409 21 20 0 0 1.000
24 466 5 896 26 436 435 24 25 1 0 0.314
Total 900 9 1735 47 845 845 45 46 1 1 0.651
FRA-PRI 21 170 10 313 7 153 153 7 7 0 0 1.000
SWE-NSW 02 77 0 152 2 75 75 2 2 0 0 1.000
03 89 2 169 5 82 82 5 5 0 0 1.000
Total 166 2 321 7 157 157 7 7 0 0 1.000
UNK-BEL 21 145 2 276 10 133 133 10 10 0 0 1.000
Total 2417 30 4647 127 2261 2262 125 124 1 2 0.728

O:Observed number of the specific genotype
E:Expected number of the specific genotype
npc:Not possible to calculate due to non-occurrence of some alleles
Updated on 2008-12-08