Index

Hardy-Weinberg equilibrium tests in the subcohort for SNPs of the SEZ6L gene:

  1. SEZ6L_MG_426 (rs137205)
  2. SEZ6L_MG_427 (rs137209)
  3. SEZ6L_MG_442 (rs6005015)
  4. SEZ6L_MG_444 (rs688034)
  5. SEZ6L_MG_457 (rs6005016)

SEZ6L_MG_426  (rs137205)

RUA cohort N N
miss		 Allele
frequencies		 Genotype distribution p-value
G/G G/A A/A
G A O E O E O E
FIN-ATB 21 1037 9 1438 618 500 503 438 432 90 93 0.710
FIN-FIN 03 434 3 620 242 220 223 180 174 31 34 0.550
24 466 5 682 240 250 252 182 178 29 31 0.628
Total 900 8 1302 482 470 475 362 352 60 65 0.397
FRA-PRI 21 170 5 232 98 77 82 78 69 10 15 0.096
SWE-NSW 02 77 0 108 46 35 38 38 32 4 7 0.173
03 89 1 116 60 38 38 40 40 10 10 1.000
Total 166 1 224 106 73 76 78 72 14 17 0.290
UNK-BEL 21 145 2 181 105 55 57 71 66 17 19 0.473
Total 2418 25 3377 1409 1175 1191 1027 994 191 207 0.106

SEZ6L_MG_427  (rs137209)

RUA cohort N N
miss		 Allele
frequencies		 Genotype distribution p-value
G/G G/A A/A
G A O E O E O E
FIN-ATB 21 1037 10 1367 687 449 455 469 457 109 115 0.398
FIN-FIN 03 434 3 592 270 203 203 186 185 42 42 1.000
24 466 5 640 282 214 222 212 196 35 43 0.080
Total 900 8 1232 552 417 425 398 381 77 85 0.208
FRA-PRI 21 170 3 214 120 64 69 86 77 17 22 0.133
SWE-NSW 02 77 0 108 46 35 38 38 32 4 7 0.172
03 89 1 113 63 37 36 39 40 12 11 0.647
Total 166 1 221 109 72 74 77 73 16 18 0.484
UNK-BEL 21 145 2 168 118 48 49 72 69 23 24 0.731
Total 2418 24 3202 1586 1050 1071 1102 1061 242 263 0.058

SEZ6L_MG_442  (rs6005015)

RUA cohort N N
miss		 Allele
frequencies		 Genotype distribution p-value
T/T T/C C/C
T C O E O E O E
FIN-ATB 21 1037 11 1426 626 487 495 452 435 87 95 0.238
FIN-FIN 03 434 2 597 267 212 206 173 184 47 41 0.175
24 466 5 660 262 234 236 192 188 35 37 0.647
Total 900 7 1257 529 446 442 365 372 82 78 0.521
FRA-PRI 21 170 3 213 121 70 68 73 77 24 22 0.506
SWE-NSW 02 77 0 122 32 47 48 28 25 2 3 0.500
03 89 1 117 59 38 39 41 39 9 10 0.639
Total 166 1 239 91 85 87 69 66 11 13 0.560
UNK-BEL 21 145 2 178 108 56 55 66 67 21 20 0.860
Total 2418 24 3313 1475 1144 1146 1025 1021 225 227 0.848

SEZ6L_MG_444  (rs688034)

RUA cohort N N
miss		 Allele
frequencies		 Genotype distribution p-value
C/C C/T T/T
C T O E O E O E
FIN-ATB 21 1037 9 1502 554 546 549 410 405 72 75 0.694
FIN-FIN 03 434 4 640 220 235 238 170 164 25 28 0.449
24 466 5 714 208 277 276 160 161 24 23 0.894
Total 900 9 1354 428 512 514 330 325 49 51 0.714
FRA-PRI 21 170 4 224 108 70 76 84 73 12 18 0.054
SWE-NSW 02 77 0 106 48 35 36 36 33 6 7 0.595
03 89 1 114 62 32 37 50 40 6 11 0.035
Total 166 1 220 110 67 73 86 73 12 18 0.035
UNK-BEL 21 145 2 173 113 53 52 67 68 23 22 0.861
Total 2418 25 3473 1313 1248 1260 977 953 168 180 0.218

SEZ6L_MG_457  (rs6005016)

RUA cohort N N
miss		 Allele
frequencies		 Genotype distribution p-value
G/G G/A A/A
G A O E O E O E
FIN-ATB 21 1036 7 1987 71 962 959 63 69 4 1 0.006
FIN-FIN 03 434 4 841 19 411 411 19 19 0 0 1.000
24 466 5 891 31 430 431 31 30 0 1 0.666
Total 900 9 1732 50 841 842 50 49 0 1 0.639
FRA-PRI 21 170 13 302 12 145 145 12 12 0 0 1.000
SWE-NSW 02 77 0 147 7 70 70 7 7 0 0 1.000
03 89 3 169 3 83 83 3 3 0 0 1.000
Total 166 3 316 10 153 153 10 10 0 0 1.000
UNK-BEL 21 145 3 261 23 119 120 23 21 0 1 0.599
Total 2417 35 4598 166 2220 2219 158 160 4 3 0.533

O:Observed number of the specific genotype
E:Expected number of the specific genotype
npc:Not possible to calculate due to non-occurrence of some alleles
Updated on 2008-12-08