Index

Hardy-Weinberg equilibrium tests in the subcohort for SNPs of the SMAD3 gene:

  1. SMAD3_MG_424 (rs12913547)
  2. SMAD3_MG_431 (rs1866317)
  3. SMAD3_MG_452 (rs17228212)

SMAD3_MG_424  (rs12913547)

RUA cohort N N
miss		 Allele
frequencies		 Genotype distribution p-value
T/T T/C C/C
T C O E O E O E
FIN-ATB 21 1037 9 1462 594 511 520 440 422 77 86 0.196
FIN-FIN 03 434 2 631 233 230 230 171 170 31 31 1.000
24 466 5 664 258 244 239 176 186 41 36 0.298
Total 900 7 1295 491 474 469 347 356 72 67 0.452
FRA-PRI 21 170 3 251 83 95 94 61 62 11 10 0.681
SWE-NSW 02 77 0 128 26 53 53 22 22 2 2 1.000
03 89 1 141 35 58 56 25 28 5 3 0.345
Total 166 1 269 61 111 110 47 50 7 6 0.449
UNK-BEL 21 145 2 225 61 89 89 47 48 7 7 0.808
Total 2418 22 3502 1290 1280 1280 942 943 174 174 1.000

SMAD3_MG_431  (rs1866317)

RUA cohort N N
miss		 Allele
frequencies		 Genotype distribution p-value
G/G G/C C/C
G C O E O E O E
FIN-ATB 21 1037 9 1744 312 739 740 266 265 23 24 0.903
FIN-FIN 03 434 2 753 111 325 328 103 97 4 7 0.203
24 466 5 813 109 354 358 105 96 2 6 0.073
Total 900 7 1566 220 679 687 208 193 6 14 0.019
FRA-PRI 21 170 4 291 41 128 128 35 36 3 3 0.746
SWE-NSW 02 77 0 137 17 61 61 15 15 1 1 1.000
03 89 1 159 17 73 72 13 15 2 1 0.046
Total 166 1 296 34 134 133 28 30 3 2 0.388
UNK-BEL 21 145 2 250 36 109 109 32 31 2 2 1.000
Total 2418 23 4147 643 1789 1795 569 557 37 43 0.293

SMAD3_MG_452  (rs17228212)

RUA cohort N N
miss		 Allele
frequencies		 Genotype distribution p-value
T/T T/C C/C
T C O E O E O E
FIN-ATB 21 1036 7 1634 424 645 649 344 337 40 44 0.506
FIN-FIN 03 434 5 663 195 257 256 149 151 23 22 0.786
24 466 5 715 207 277 277 161 161 23 23 1.000
Total 900 10 1378 402 534 533 310 311 46 45 0.924
FRA-PRI 21 170 10 233 87 83 85 67 63 10 12 0.555
SWE-NSW 02 77 0 103 51 36 34 31 34 10 8 0.450
03 89 2 128 46 47 47 34 34 6 6 1.000
Total 166 2 231 97 83 81 65 68 16 14 0.580
UNK-BEL 21 145 2 187 99 59 61 69 65 15 17 0.462
Total 2417 31 3663 1109 1404 1406 855 851 127 129 0.864

O:Observed number of the specific genotype
E:Expected number of the specific genotype
npc:Not possible to calculate due to non-occurrence of some alleles
Updated on 2008-12-08