Cox regression for CHD1 endpoint, test for multiplicative allele effects, men and women

rank SNP RS-code Chromosome Success Genotype Cases Non-cases Total HR (95% CI) nominal p-value tail-area FDR
1 9P21_3_MG_425 rs1333049 9 99.6% C/C 223 (21%) 314 (17%) 537 1.197
(1.067, 1.344)		 0.00221 0.09276
C/G 518 (49%) 925 (49%) 1443
G/G 309 (29%) 639 (34%) 948
2 9P21_3_MG_420 rs10738610 9 99.2% A/A 305 (29%) 621 (33%) 926 0.846
(0.754, 0.949)		 0.00444 0.09328
A/C 515 (49%) 925 (49%) 1440
C/C 227 (22%) 323 (17%) 550
3 MIA3_MG_454 rs3008621 1 98.6% A/A 19 (2%) 51 (3%) 70 0.827
(0.700, 0.978)		 0.02602 0.36435
A/G 225 (22%) 457 (25%) 682
G/G 798 (77%) 1350 (73%) 2148
4 MTHFD1L_MG_423 rs12525353 6 99.4% A/A 0 (0%) 2 (0%) 2 0.633
(0.401, 1.000)		 0.04994 0.52439
A/C 30 (3%) 75 (4%) 105
C/C 1016 (97%) 1799 (96%) 2815
5 SMAD3_MG_424 rs12913547 15 99.6% C/C 84 (8%) 132 (7%) 216 1.122
(0.986, 1.275)		 0.07985 0.67075
C/T 427 (41%) 730 (39%) 1157
T/T 539 (51%) 1016 (54%) 1555
6 9P21_3_MG_421 rs10757283 9 99.4% C/C 274 (26%) 546 (29%) 820 0.923
(0.824, 1.035)		 0.16913 0.99037
C/T 547 (52%) 945 (50%) 1492
T/T 227 (22%) 382 (20%) 609
7 SEZ6L_MG_442 rs6005015 22 99.6% C/C 87 (8%) 171 (9%) 258 0.920
(0.810, 1.044)		 0.19718 0.99037
C/T 442 (42%) 817 (44%) 1259
T/T 521 (50%) 889 (47%) 1410
8 9P21_3_MG_437 rs496892 9 98.8% C/C 286 (27%) 473 (25%) 759 1.068
(0.948, 1.204)		 0.27805 0.99037
C/T 524 (50%) 968 (52%) 1492
T/T 231 (22%) 424 (23%) 655
9 2Q36_3_MG_447 rs7597168 2 99.4% C/C 577 (55%) 1052 (56%) 1629 0.930
(0.813, 1.063)		 0.28679 0.99037
C/T 407 (39%) 712 (38%) 1119
T/T 63 (6%) 110 (6%) 173
10 SEZ6L_MG_426 rs137205 22 99.5% A/A 79 (8%) 152 (8%) 231 0.936
(0.822, 1.065)		 0.31214 0.99037
A/G 430 (41%) 812 (43%) 1242
G/G 540 (51%) 912 (49%) 1452
11 SEZ6L_MG_444 rs688034 22 99.5% C/C 570 (54%) 972 (52%) 1542 1.069
(0.938, 1.219)		 0.31762 0.99037
C/T 407 (39%) 770 (41%) 1177
T/T 73 (7%) 134 (7%) 207
12 CELSR2_MG_434 rs413380 1 99.6% C/C 966 (92%) 1702 (91%) 2668 1.121
(0.862, 1.456)		 0.39455 0.99037
C/T 81 (8%) 166 (9%) 247
T/T 3 (0%) 9 (0%) 12
13 MTHFD1L_MG_445 rs6922269 6 99.4% A/A 58 (6%) 99 (5%) 157 1.058
(0.925, 1.210)		 0.41094 0.99037
A/G 387 (37%) 666 (36%) 1053
G/G 603 (58%) 1108 (59%) 1711
14 19Q12_MG_422 rs11670734 19 99.6% C/C 95 (9%) 150 (8%) 245 1.052
(0.925, 1.197)		 0.44096 0.99037
C/G 426 (41%) 763 (41%) 1189
G/G 529 (50%) 964 (51%) 1493
15 19Q12_MG_446 rs7250581 19 98.2% A/A 30 (3%) 47 (3%) 77 1.064
(0.908, 1.246)		 0.44227 0.99037
A/G 257 (25%) 433 (23%) 690
G/G 754 (72%) 1366 (74%) 2120
16 MIA3_MG_430 rs17465637 1 99.2% A/A 73 (7%) 143 (8%) 216 0.953
(0.836, 1.086)		 0.46833 0.99037
A/C 377 (36%) 695 (37%) 1072
C/C 595 (57%) 1033 (55%) 1628
17 9P21_3_MG_451 rs1537378 9 98.2% A/A 123 (12%) 268 (14%) 391 0.960
(0.854, 1.079)		 0.49316 0.99037
A/G 532 (51%) 896 (48%) 1428
G/G 383 (37%) 686 (37%) 1069
18 2Q36_3_MG_461 rs2943634 2 96.8% A/A 123 (12%) 236 (13%) 359 0.962
(0.852, 1.086)		 0.53078 0.99037
A/C 447 (44%) 833 (45%) 1280
C/C 437 (43%) 769 (42%) 1206
19 10Q11_21_MG_458 rs622472 10 98.4% A/A 737 (71%) 1295 (70%) 2032 1.050
(0.900, 1.227)		 0.53377 0.99037
A/C 268 (26%) 514 (28%) 782
C/C 33 (3%) 47 (3%) 80
20 PSRC1_MG_460 rs599839 1 99.3% A/A 620 (60%) 1086 (58%) 1706 1.041
(0.912, 1.188)		 0.55432 0.99037
A/G 361 (35%) 674 (36%) 1035
G/G 60 (6%) 117 (6%) 177
21 10Q11_21_MG_456 rs513391 10 99.1% A/A 742 (71%) 1310 (70%) 2052 1.042
(0.892, 1.217)		 0.60516 0.99037
A/C 272 (26%) 513 (27%) 785
C/C 32 (3%) 46 (2%) 78
22 CELSR2_MG_438 rs4970834 1 99.4% C/C 660 (63%) 1181 (63%) 1841 0.963
(0.835, 1.111)		 0.60715 0.99037
C/T 342 (33%) 617 (33%) 959
T/T 45 (4%) 77 (4%) 122
23 5Q21_1_MG_435 rs436495 5 98.8% A/A 56 (5%) 113 (6%) 169 0.965
(0.843, 1.105)		 0.60852 0.99037
A/G 360 (35%) 650 (35%) 1010
G/G 625 (60%) 1101 (59%) 1726
24 9P21_3_MG_459 rs7865618 9 98.9% A/A 345 (33%) 616 (33%) 961 1.030
(0.919, 1.154)		 0.61183 0.99037
A/G 530 (51%) 914 (49%) 1444
G/G 168 (16%) 334 (18%) 502
25 10Q11_21_MG_429 rs1746049 10 99.5% C/C 798 (76%) 1425 (76%) 2223 0.963
(0.812, 1.141)		 0.66130 0.99037
C/T 228 (22%) 425 (23%) 653
T/T 23 (2%) 27 (1%) 50
26 10Q11_21_MG_443 rs687175 10 99.4% C/C 32 (3%) 45 (2%) 77 0.969
(0.830, 1.132)		 0.69331 0.99037
C/T 273 (26%) 515 (27%) 788
T/T 743 (71%) 1315 (70%) 2058
27 SMAD3_MG_452 rs17228212 15 99.1% C/C 56 (5%) 103 (6%) 159 0.972
(0.845, 1.119)		 0.69717 0.99037
C/T 378 (36%) 682 (36%) 1060
T/T 611 (58%) 1085 (58%) 1696
28 10Q11_21_MG_428 rs1746048 10 99.5% C/C 745 (71%) 1319 (70%) 2064 1.030
(0.881, 1.204)		 0.71436 0.99037
C/T 273 (26%) 513 (27%) 786
T/T 31 (3%) 45 (2%) 76
29 5Q21_1_MG_455 rs383830 5 99.1% A/A 44 (4%) 101 (5%) 145 0.977
(0.851, 1.122)		 0.74163 0.99037
A/T 339 (32%) 587 (31%) 926
T/T 663 (63%) 1180 (63%) 1843
30 5Q21_1_MG_441 rs565928 5 99.5% C/C 664 (63%) 1181 (63%) 1845 1.023
(0.891, 1.175)		 0.74214 0.99037
C/T 340 (32%) 593 (32%) 933
T/T 46 (4%) 102 (5%) 148
31 10Q11_21_MG_440 rs559580 10 99.2% C/C 32 (3%) 45 (2%) 77 0.975
(0.834, 1.138)		 0.74429 0.99037
C/T 272 (26%) 509 (27%) 781
T/T 744 (71%) 1314 (70%) 2058
32 5Q21_1_MG_436 rs449650 5 99.1% G/G 663 (63%) 1180 (63%) 1843 1.019
(0.887, 1.170)		 0.79221 0.99037
G/T 339 (32%) 584 (31%) 923
T/T 46 (4%) 103 (6%) 149
33 SMAD3_MG_431 rs1866317 15 99.6% C/C 20 (2%) 27 (1%) 47 1.022
(0.861, 1.214)		 0.80130 0.99037
C/G 245 (23%) 447 (24%) 692
G/G 785 (75%) 1403 (75%) 2188
34 SEZ6L_MG_457 rs6005016 22 99.0% A/A 1 (0%) 4 (0%) 5 1.026
(0.766, 1.374)		 0.86237 0.99037
A/G 76 (7%) 126 (7%) 202
G/G 967 (93%) 1737 (93%) 2704
35 1Q31_2_MG_453 rs1936982 1 99.0% C/C 141 (14%) 238 (13%) 379 1.010
(0.896, 1.138)		 0.87524 0.99037
C/T 450 (43%) 816 (44%) 1266
T/T 452 (43%) 815 (44%) 1267
36 12Q12_MG_448 rs7970834 12 99.5% G/G 310 (30%) 592 (32%) 902 0.995
(0.885, 1.119)		 0.93985 0.99037
G/T 546 (52%) 941 (50%) 1487
T/T 191 (18%) 344 (18%) 535
37 2Q36_3_MG_433 rs2972147 2 98.6% C/C 429 (41%) 756 (41%) 1185 1.004
(0.892, 1.130)		 0.94551 0.99037
C/T 472 (45%) 843 (45%) 1315
T/T 139 (13%) 259 (14%) 398
38 MTHFD1L_MG_449 rs12214306 6 99.2% C/C 1 (0%) 1 (0%) 2 0.988
(0.681, 1.434)		 0.95129 0.99037
C/T 50 (5%) 93 (5%) 143
T/T 995 (95%) 1777 (95%) 2772
39 10Q11_21_MG_439 rs501120 10 96.9% C/C 32 (3%) 44 (2%) 76 1.003
(0.856, 1.175)		 0.97400 0.99037
C/T 249 (24%) 456 (25%) 705
T/T 746 (73%) 1322 (73%) 2068
40 FMN2_MG_450 rs1456648 1 98.7% G/G 20 (2%) 46 (2%) 66 1.002
(0.856, 1.173)		 0.98013 0.99037
G/T 269 (26%) 486 (26%) 755
T/T 752 (72%) 1328 (71%) 2080
41 SEZ6L_MG_427 rs137209 22 99.6% A/A 104 (10%) 194 (10%) 298 1.001
(0.884, 1.134)		 0.98759 0.99037
A/G 482 (46%) 868 (46%) 1350
G/G 464 (44%) 816 (43%) 1280
42 10Q11_21_MG_432 rs2146807 10 99.4% C/C 11 (1%) 15 (1%) 26 1.001
(0.815, 1.230)		 0.99037 0.99037
C/T 175 (17%) 313 (17%) 488
T/T 864 (82%) 1544 (82%) 2408

stratified by sex, adjusted for: cohort nonhdl hdla bmi bpm dsmoker hisdiab1

Updated on 2008-12-08