| rank | SNP | RS-code | Chromosome | Success | Genotype | Cases | Non-cases | Total | HR (95% CI) | nominal p-value | tail-area FDR |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 9P21_3_MG_425 | rs1333049 | 9 | 99.6% | C/C | 223 (21%) | 314 (17%) | 537 | 1.204 (1.078, 1.343) |
0.00095 | 0.03998 |
| C/G | 518 (49%) | 925 (49%) | 1443 | ||||||||
| G/G | 309 (29%) | 639 (34%) | 948 | ||||||||
| 2 | 9P21_3_MG_420 | rs10738610 | 9 | 99.2% | A/A | 305 (29%) | 621 (33%) | 926 | 0.844 (0.756, 0.942) |
0.00242 | 0.05085 |
| A/C | 515 (49%) | 925 (49%) | 1440 | ||||||||
| C/C | 227 (22%) | 323 (17%) | 550 | ||||||||
| 3 | MTHFD1L_MG_423 | rs12525353 | 6 | 99.4% | A/A | 0 (0%) | 2 (0%) | 2 | 0.610 (0.396, 0.940) |
0.02513 | 0.35178 |
| A/C | 30 (3%) | 75 (4%) | 105 | ||||||||
| C/C | 1016 (97%) | 1799 (96%) | 2815 | ||||||||
| 4 | MIA3_MG_454 | rs3008621 | 1 | 98.6% | A/A | 19 (2%) | 51 (3%) | 70 | 0.850 (0.725, 0.995) |
0.04346 | 0.45630 |
| A/G | 225 (22%) | 457 (25%) | 682 | ||||||||
| G/G | 798 (77%) | 1350 (73%) | 2148 | ||||||||
| 5 | SEZ6L_MG_442 | rs6005015 | 22 | 99.6% | C/C | 87 (8%) | 171 (9%) | 258 | 0.904 (0.801, 1.020) |
0.10005 | 0.81684 |
| C/T | 442 (42%) | 817 (44%) | 1259 | ||||||||
| T/T | 521 (50%) | 889 (47%) | 1410 | ||||||||
| 6 | SMAD3_MG_424 | rs12913547 | 15 | 99.6% | C/C | 84 (8%) | 132 (7%) | 216 | 1.101 (0.976, 1.242) |
0.11669 | 0.81684 |
| C/T | 427 (41%) | 730 (39%) | 1157 | ||||||||
| T/T | 539 (51%) | 1016 (54%) | 1555 | ||||||||
| 7 | 9P21_3_MG_437 | rs496892 | 9 | 98.8% | C/C | 286 (27%) | 473 (25%) | 759 | 1.077 (0.965, 1.203) |
0.18412 | 0.83267 |
| C/T | 524 (50%) | 968 (52%) | 1492 | ||||||||
| T/T | 231 (22%) | 424 (23%) | 655 | ||||||||
| 8 | 9P21_3_MG_421 | rs10757283 | 9 | 99.4% | C/C | 274 (26%) | 546 (29%) | 820 | 0.931 (0.837, 1.035) |
0.18441 | 0.83267 |
| C/T | 547 (52%) | 945 (50%) | 1492 | ||||||||
| T/T | 227 (22%) | 382 (20%) | 609 | ||||||||
| 9 | MTHFD1L_MG_445 | rs6922269 | 6 | 99.4% | A/A | 58 (6%) | 99 (5%) | 157 | 1.081 (0.952, 1.228) |
0.22728 | 0.83267 |
| A/G | 387 (37%) | 666 (36%) | 1053 | ||||||||
| G/G | 603 (58%) | 1108 (59%) | 1711 | ||||||||
| 10 | SEZ6L_MG_426 | rs137205 | 22 | 99.5% | A/A | 79 (8%) | 152 (8%) | 231 | 0.931 (0.822, 1.053) |
0.25451 | 0.83267 |
| A/G | 430 (41%) | 812 (43%) | 1242 | ||||||||
| G/G | 540 (51%) | 912 (49%) | 1452 | ||||||||
| 11 | CELSR2_MG_434 | rs413380 | 1 | 99.6% | C/C | 966 (92%) | 1702 (91%) | 2668 | 1.154 (0.898, 1.482) |
0.26223 | 0.83267 |
| C/T | 81 (8%) | 166 (9%) | 247 | ||||||||
| T/T | 3 (0%) | 9 (0%) | 12 | ||||||||
| 12 | SEZ6L_MG_444 | rs688034 | 22 | 99.5% | C/C | 570 (54%) | 972 (52%) | 1542 | 1.075 (0.947, 1.219) |
0.26329 | 0.83267 |
| C/T | 407 (39%) | 770 (41%) | 1177 | ||||||||
| T/T | 73 (7%) | 134 (7%) | 207 | ||||||||
| 13 | PSRC1_MG_460 | rs599839 | 1 | 99.3% | A/A | 620 (60%) | 1086 (58%) | 1706 | 1.073 (0.947, 1.216) |
0.26739 | 0.83267 |
| A/G | 361 (35%) | 674 (36%) | 1035 | ||||||||
| G/G | 60 (6%) | 117 (6%) | 177 | ||||||||
| 14 | 9P21_3_MG_451 | rs1537378 | 9 | 98.2% | A/A | 123 (12%) | 268 (14%) | 391 | 0.941 (0.844, 1.050) |
0.27756 | 0.83267 |
| A/G | 532 (51%) | 896 (48%) | 1428 | ||||||||
| G/G | 383 (37%) | 686 (37%) | 1069 | ||||||||
| 15 | 2Q36_3_MG_461 | rs2943634 | 2 | 96.8% | A/A | 123 (12%) | 236 (13%) | 359 | 0.945 (0.843, 1.059) |
0.32930 | 0.92093 |
| A/C | 447 (44%) | 833 (45%) | 1280 | ||||||||
| C/C | 437 (43%) | 769 (42%) | 1206 | ||||||||
| 16 | 9P21_3_MG_459 | rs7865618 | 9 | 98.9% | A/A | 345 (33%) | 616 (33%) | 961 | 1.052 (0.946, 1.170) |
0.35083 | 0.92093 |
| A/G | 530 (51%) | 914 (49%) | 1444 | ||||||||
| G/G | 168 (16%) | 334 (18%) | 502 | ||||||||
| 17 | 19Q12_MG_446 | rs7250581 | 19 | 98.2% | A/A | 30 (3%) | 47 (3%) | 77 | 1.069 (0.919, 1.244) |
0.38660 | 0.95513 |
| A/G | 257 (25%) | 433 (23%) | 690 | ||||||||
| G/G | 754 (72%) | 1366 (74%) | 2120 | ||||||||
| 18 | MIA3_MG_430 | rs17465637 | 1 | 99.2% | A/A | 73 (7%) | 143 (8%) | 216 | 0.958 (0.848, 1.083) |
0.49476 | 0.98992 |
| A/C | 377 (36%) | 695 (37%) | 1072 | ||||||||
| C/C | 595 (57%) | 1033 (55%) | 1628 | ||||||||
| 19 | 2Q36_3_MG_433 | rs2972147 | 2 | 98.6% | C/C | 429 (41%) | 756 (41%) | 1185 | 1.037 (0.928, 1.158) |
0.52030 | 0.98992 |
| C/T | 472 (45%) | 843 (45%) | 1315 | ||||||||
| T/T | 139 (13%) | 259 (14%) | 398 | ||||||||
| 20 | 2Q36_3_MG_447 | rs7597168 | 2 | 99.4% | C/C | 577 (55%) | 1052 (56%) | 1629 | 0.960 (0.847, 1.089) |
0.52907 | 0.98992 |
| C/T | 407 (39%) | 712 (38%) | 1119 | ||||||||
| T/T | 63 (6%) | 110 (6%) | 173 | ||||||||
| 21 | 5Q21_1_MG_441 | rs565928 | 5 | 99.5% | C/C | 664 (63%) | 1181 (63%) | 1845 | 1.037 (0.910, 1.180) |
0.58766 | 0.98992 |
| C/T | 340 (32%) | 593 (32%) | 933 | ||||||||
| T/T | 46 (4%) | 102 (5%) | 148 | ||||||||
| 22 | 19Q12_MG_422 | rs11670734 | 19 | 99.6% | C/C | 95 (9%) | 150 (8%) | 245 | 1.034 (0.915, 1.169) |
0.59033 | 0.98992 |
| C/G | 426 (41%) | 763 (41%) | 1189 | ||||||||
| G/G | 529 (50%) | 964 (51%) | 1493 | ||||||||
| 23 | 5Q21_1_MG_435 | rs436495 | 5 | 98.8% | A/A | 56 (5%) | 113 (6%) | 169 | 0.966 (0.851, 1.097) |
0.59543 | 0.98992 |
| A/G | 360 (35%) | 650 (35%) | 1010 | ||||||||
| G/G | 625 (60%) | 1101 (59%) | 1726 | ||||||||
| 24 | 5Q21_1_MG_455 | rs383830 | 5 | 99.1% | A/A | 44 (4%) | 101 (5%) | 145 | 0.965 (0.848, 1.099) |
0.59582 | 0.98992 |
| A/T | 339 (32%) | 587 (31%) | 926 | ||||||||
| T/T | 663 (63%) | 1180 (63%) | 1843 | ||||||||
| 25 | MTHFD1L_MG_449 | rs12214306 | 6 | 99.2% | C/C | 1 (0%) | 1 (0%) | 2 | 0.921 (0.646, 1.313) |
0.65001 | 0.98992 |
| C/T | 50 (5%) | 93 (5%) | 143 | ||||||||
| T/T | 995 (95%) | 1777 (95%) | 2772 | ||||||||
| 26 | 5Q21_1_MG_436 | rs449650 | 5 | 99.1% | G/G | 663 (63%) | 1180 (63%) | 1843 | 1.028 (0.903, 1.169) |
0.68029 | 0.98992 |
| G/T | 339 (32%) | 584 (31%) | 923 | ||||||||
| T/T | 46 (4%) | 103 (6%) | 149 | ||||||||
| 27 | FMN2_MG_450 | rs1456648 | 1 | 98.7% | G/G | 20 (2%) | 46 (2%) | 66 | 0.972 (0.838, 1.127) |
0.70323 | 0.98992 |
| G/T | 269 (26%) | 486 (26%) | 755 | ||||||||
| T/T | 752 (72%) | 1328 (71%) | 2080 | ||||||||
| 28 | 10Q11_21_MG_439 | rs501120 | 10 | 96.9% | C/C | 32 (3%) | 44 (2%) | 76 | 1.026 (0.883, 1.192) |
0.74054 | 0.98992 |
| C/T | 249 (24%) | 456 (25%) | 705 | ||||||||
| T/T | 746 (73%) | 1322 (73%) | 2068 | ||||||||
| 29 | SMAD3_MG_452 | rs17228212 | 15 | 99.1% | C/C | 56 (5%) | 103 (6%) | 159 | 0.979 (0.859, 1.117) |
0.75707 | 0.98992 |
| C/T | 378 (36%) | 682 (36%) | 1060 | ||||||||
| T/T | 611 (58%) | 1085 (58%) | 1696 | ||||||||
| 30 | 10Q11_21_MG_458 | rs622472 | 10 | 98.4% | A/A | 737 (71%) | 1295 (70%) | 2032 | 1.023 (0.883, 1.185) |
0.76490 | 0.98992 |
| A/C | 268 (26%) | 514 (28%) | 782 | ||||||||
| C/C | 33 (3%) | 47 (3%) | 80 | ||||||||
| 31 | SMAD3_MG_431 | rs1866317 | 15 | 99.6% | C/C | 20 (2%) | 27 (1%) | 47 | 1.025 (0.872, 1.204) |
0.76640 | 0.98992 |
| C/G | 245 (23%) | 447 (24%) | 692 | ||||||||
| G/G | 785 (75%) | 1403 (75%) | 2188 | ||||||||
| 32 | 10Q11_21_MG_429 | rs1746049 | 10 | 99.5% | C/C | 798 (76%) | 1425 (76%) | 2223 | 0.979 (0.833, 1.151) |
0.79910 | 0.98992 |
| C/T | 228 (22%) | 425 (23%) | 653 | ||||||||
| T/T | 23 (2%) | 27 (1%) | 50 | ||||||||
| 33 | SEZ6L_MG_427 | rs137209 | 22 | 99.6% | A/A | 104 (10%) | 194 (10%) | 298 | 0.985 (0.875, 1.109) |
0.80248 | 0.98992 |
| A/G | 482 (46%) | 868 (46%) | 1350 | ||||||||
| G/G | 464 (44%) | 816 (43%) | 1280 | ||||||||
| 34 | SEZ6L_MG_457 | rs6005016 | 22 | 99.0% | A/A | 1 (0%) | 4 (0%) | 5 | 0.976 (0.738, 1.291) |
0.86515 | 0.98992 |
| A/G | 76 (7%) | 126 (7%) | 202 | ||||||||
| G/G | 967 (93%) | 1737 (93%) | 2704 | ||||||||
| 35 | 10Q11_21_MG_456 | rs513391 | 10 | 99.1% | A/A | 742 (71%) | 1310 (70%) | 2052 | 1.011 (0.873, 1.172) |
0.88232 | 0.98992 |
| A/C | 272 (26%) | 513 (27%) | 785 | ||||||||
| C/C | 32 (3%) | 46 (2%) | 78 | ||||||||
| 36 | 10Q11_21_MG_432 | rs2146807 | 10 | 99.4% | C/C | 11 (1%) | 15 (1%) | 26 | 1.012 (0.836, 1.224) |
0.90361 | 0.98992 |
| C/T | 175 (17%) | 313 (17%) | 488 | ||||||||
| T/T | 864 (82%) | 1544 (82%) | 2408 | ||||||||
| 37 | 12Q12_MG_448 | rs7970834 | 12 | 99.5% | G/G | 310 (30%) | 592 (32%) | 902 | 0.995 (0.892, 1.110) |
0.92326 | 0.98992 |
| G/T | 546 (52%) | 941 (50%) | 1487 | ||||||||
| T/T | 191 (18%) | 344 (18%) | 535 | ||||||||
| 38 | 10Q11_21_MG_443 | rs687175 | 10 | 99.4% | C/C | 32 (3%) | 45 (2%) | 77 | 0.995 (0.859, 1.153) |
0.94693 | 0.98992 |
| C/T | 273 (26%) | 515 (27%) | 788 | ||||||||
| T/T | 743 (71%) | 1315 (70%) | 2058 | ||||||||
| 39 | 10Q11_21_MG_428 | rs1746048 | 10 | 99.5% | C/C | 745 (71%) | 1319 (70%) | 2064 | 1.005 (0.867, 1.165) |
0.94816 | 0.98992 |
| C/T | 273 (26%) | 513 (27%) | 786 | ||||||||
| T/T | 31 (3%) | 45 (2%) | 76 | ||||||||
| 40 | 1Q31_2_MG_453 | rs1936982 | 1 | 99.0% | C/C | 141 (14%) | 238 (13%) | 379 | 1.003 (0.897, 1.122) |
0.95408 | 0.98992 |
| C/T | 450 (43%) | 816 (44%) | 1266 | ||||||||
| T/T | 452 (43%) | 815 (44%) | 1267 | ||||||||
| 41 | CELSR2_MG_438 | rs4970834 | 1 | 99.4% | C/C | 660 (63%) | 1181 (63%) | 1841 | 1.003 (0.877, 1.146) |
0.96737 | 0.98992 |
| C/T | 342 (33%) | 617 (33%) | 959 | ||||||||
| T/T | 45 (4%) | 77 (4%) | 122 | ||||||||
| 42 | 10Q11_21_MG_440 | rs559580 | 10 | 99.2% | C/C | 32 (3%) | 45 (2%) | 77 | 0.999 (0.862, 1.158) |
0.98992 | 0.98992 |
| C/T | 272 (26%) | 509 (27%) | 781 | ||||||||
| T/T | 744 (71%) | 1314 (70%) | 2058 |
Updated on 2008-12-08
