| rank | SNP | RS-code | Chromosome | Success | Genotype | Cases | Non-cases | Total | HR (95% CI) | nominal p-value | tail-area FDR |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | SEZ6L_MG_444 | rs688034 | 22 | 99.5% | C/C | 570 (54%) | 972 (52%) | 1542 | 1.320 (1.073, 1.625) |
0.00875 | 0.26867 |
| C/T | 407 (39%) | 770 (41%) | 1177 | ||||||||
| T/T | 73 (7%) | 134 (7%) | 207 | ||||||||
| 2 | SEZ6L_MG_426 | rs137205 | 22 | 99.5% | A/A | 79 (8%) | 152 (8%) | 231 | 0.776 (0.635, 0.947) |
0.01279 | 0.26867 |
| A/G | 430 (41%) | 812 (43%) | 1242 | ||||||||
| G/G | 540 (51%) | 912 (49%) | 1452 | ||||||||
| 3 | SEZ6L_MG_442 | rs6005015 | 22 | 99.6% | C/C | 87 (8%) | 171 (9%) | 258 | 0.794 (0.648, 0.974) |
0.02658 | 0.28393 |
| C/T | 442 (42%) | 817 (44%) | 1259 | ||||||||
| T/T | 521 (50%) | 889 (47%) | 1410 | ||||||||
| 4 | SEZ6L_MG_427 | rs137209 | 22 | 99.6% | A/A | 104 (10%) | 194 (10%) | 298 | 0.804 (0.662, 0.975) |
0.02704 | 0.28393 |
| A/G | 482 (46%) | 868 (46%) | 1350 | ||||||||
| G/G | 464 (44%) | 816 (43%) | 1280 | ||||||||
| 5 | 9P21_3_MG_421 | rs10757283 | 9 | 99.4% | C/C | 274 (26%) | 546 (29%) | 820 | 0.849 (0.716, 1.007) |
0.06058 | 0.43603 |
| C/T | 547 (52%) | 945 (50%) | 1492 | ||||||||
| T/T | 227 (22%) | 382 (20%) | 609 | ||||||||
| 6 | MIA3_MG_454 | rs3008621 | 1 | 98.6% | A/A | 19 (2%) | 51 (3%) | 70 | 0.805 (0.635, 1.019) |
0.07164 | 0.43603 |
| A/G | 225 (22%) | 457 (25%) | 682 | ||||||||
| G/G | 798 (77%) | 1350 (73%) | 2148 | ||||||||
| 7 | 12Q12_MG_448 | rs7970834 | 12 | 99.5% | G/G | 310 (30%) | 592 (32%) | 902 | 0.854 (0.719, 1.015) |
0.07267 | 0.43603 |
| G/T | 546 (52%) | 941 (50%) | 1487 | ||||||||
| T/T | 191 (18%) | 344 (18%) | 535 | ||||||||
| 8 | SMAD3_MG_431 | rs1866317 | 15 | 99.6% | C/C | 20 (2%) | 27 (1%) | 47 | 1.226 (0.969, 1.552) |
0.08970 | 0.47092 |
| C/G | 245 (23%) | 447 (24%) | 692 | ||||||||
| G/G | 785 (75%) | 1403 (75%) | 2188 | ||||||||
| 9 | 19Q12_MG_422 | rs11670734 | 19 | 99.6% | C/C | 95 (9%) | 150 (8%) | 245 | 1.168 (0.959, 1.424) |
0.12330 | 0.52689 |
| C/G | 426 (41%) | 763 (41%) | 1189 | ||||||||
| G/G | 529 (50%) | 964 (51%) | 1493 | ||||||||
| 10 | 9P21_3_MG_425 | rs1333049 | 9 | 99.6% | C/C | 223 (21%) | 314 (17%) | 537 | 1.148 (0.959, 1.374) |
0.13282 | 0.52689 |
| C/G | 518 (49%) | 925 (49%) | 1443 | ||||||||
| G/G | 309 (29%) | 639 (34%) | 948 | ||||||||
| 11 | 9P21_3_MG_420 | rs10738610 | 9 | 99.2% | A/A | 305 (29%) | 621 (33%) | 926 | 0.874 (0.731, 1.045) |
0.13910 | 0.52689 |
| A/C | 515 (49%) | 925 (49%) | 1440 | ||||||||
| C/C | 227 (22%) | 323 (17%) | 550 | ||||||||
| 12 | 2Q36_3_MG_433 | rs2972147 | 2 | 98.6% | C/C | 429 (41%) | 756 (41%) | 1185 | 0.876 (0.730, 1.050) |
0.15214 | 0.52689 |
| C/T | 472 (45%) | 843 (45%) | 1315 | ||||||||
| T/T | 139 (13%) | 259 (14%) | 398 | ||||||||
| 13 | SMAD3_MG_452 | rs17228212 | 15 | 99.1% | C/C | 56 (5%) | 103 (6%) | 159 | 0.849 (0.675, 1.069) |
0.16308 | 0.52689 |
| C/T | 378 (36%) | 682 (36%) | 1060 | ||||||||
| T/T | 611 (58%) | 1085 (58%) | 1696 | ||||||||
| 14 | 19Q12_MG_446 | rs7250581 | 19 | 98.2% | A/A | 30 (3%) | 47 (3%) | 77 | 1.168 (0.915, 1.490) |
0.21205 | 0.62526 |
| A/G | 257 (25%) | 433 (23%) | 690 | ||||||||
| G/G | 754 (72%) | 1366 (74%) | 2120 | ||||||||
| 15 | MTHFD1L_MG_423 | rs12525353 | 6 | 99.4% | A/A | 0 (0%) | 2 (0%) | 2 | 1.402 (0.814, 2.414) |
0.22331 | 0.62526 |
| A/C | 30 (3%) | 75 (4%) | 105 | ||||||||
| C/C | 1016 (97%) | 1799 (96%) | 2815 | ||||||||
| 16 | CELSR2_MG_434 | rs413380 | 1 | 99.6% | C/C | 966 (92%) | 1702 (91%) | 2668 | 1.233 (0.832, 1.828) |
0.29709 | 0.76936 |
| C/T | 81 (8%) | 166 (9%) | 247 | ||||||||
| T/T | 3 (0%) | 9 (0%) | 12 | ||||||||
| 17 | FMN2_MG_450 | rs1456648 | 1 | 98.7% | G/G | 20 (2%) | 46 (2%) | 66 | 0.883 (0.687, 1.134) |
0.32812 | 0.76936 |
| G/T | 269 (26%) | 486 (26%) | 755 | ||||||||
| T/T | 752 (72%) | 1328 (71%) | 2080 | ||||||||
| 18 | SMAD3_MG_424 | rs12913547 | 15 | 99.6% | C/C | 84 (8%) | 132 (7%) | 216 | 1.105 (0.904, 1.350) |
0.32973 | 0.76936 |
| C/T | 427 (41%) | 730 (39%) | 1157 | ||||||||
| T/T | 539 (51%) | 1016 (54%) | 1555 | ||||||||
| 19 | 9P21_3_MG_451 | rs1537378 | 9 | 98.2% | A/A | 123 (12%) | 268 (14%) | 391 | 0.926 (0.775, 1.108) |
0.40152 | 0.85498 |
| A/G | 532 (51%) | 896 (48%) | 1428 | ||||||||
| G/G | 383 (37%) | 686 (37%) | 1069 | ||||||||
| 20 | 1Q31_2_MG_453 | rs1936982 | 1 | 99.0% | C/C | 141 (14%) | 238 (13%) | 379 | 1.080 (0.900, 1.296) |
0.40714 | 0.85498 |
| C/T | 450 (43%) | 816 (44%) | 1266 | ||||||||
| T/T | 452 (43%) | 815 (44%) | 1267 | ||||||||
| 21 | 2Q36_3_MG_461 | rs2943634 | 2 | 96.8% | A/A | 123 (12%) | 236 (13%) | 359 | 1.074 (0.892, 1.293) |
0.45242 | 0.87660 |
| A/C | 447 (44%) | 833 (45%) | 1280 | ||||||||
| C/C | 437 (43%) | 769 (42%) | 1206 | ||||||||
| 22 | 2Q36_3_MG_447 | rs7597168 | 2 | 99.4% | C/C | 577 (55%) | 1052 (56%) | 1629 | 0.936 (0.764, 1.146) |
0.52204 | 0.87660 |
| C/T | 407 (39%) | 712 (38%) | 1119 | ||||||||
| T/T | 63 (6%) | 110 (6%) | 173 | ||||||||
| 23 | 5Q21_1_MG_455 | rs383830 | 5 | 99.1% | A/A | 44 (4%) | 101 (5%) | 145 | 0.939 (0.759, 1.161) |
0.56150 | 0.87660 |
| A/T | 339 (32%) | 587 (31%) | 926 | ||||||||
| T/T | 663 (63%) | 1180 (63%) | 1843 | ||||||||
| 24 | MTHFD1L_MG_449 | rs12214306 | 6 | 99.2% | C/C | 1 (0%) | 1 (0%) | 2 | 0.838 (0.444, 1.581) |
0.58457 | 0.87660 |
| C/T | 50 (5%) | 93 (5%) | 143 | ||||||||
| T/T | 995 (95%) | 1777 (95%) | 2772 | ||||||||
| 25 | 9P21_3_MG_437 | rs496892 | 9 | 98.8% | C/C | 286 (27%) | 473 (25%) | 759 | 1.049 (0.879, 1.253) |
0.59544 | 0.87660 |
| C/T | 524 (50%) | 968 (52%) | 1492 | ||||||||
| T/T | 231 (22%) | 424 (23%) | 655 | ||||||||
| 26 | 5Q21_1_MG_435 | rs436495 | 5 | 98.8% | A/A | 56 (5%) | 113 (6%) | 169 | 0.952 (0.776, 1.167) |
0.63510 | 0.87660 |
| A/G | 360 (35%) | 650 (35%) | 1010 | ||||||||
| G/G | 625 (60%) | 1101 (59%) | 1726 | ||||||||
| 27 | MIA3_MG_430 | rs17465637 | 1 | 99.2% | A/A | 73 (7%) | 143 (8%) | 216 | 0.956 (0.788, 1.161) |
0.64958 | 0.87660 |
| A/C | 377 (36%) | 695 (37%) | 1072 | ||||||||
| C/C | 595 (57%) | 1033 (55%) | 1628 | ||||||||
| 28 | 9P21_3_MG_459 | rs7865618 | 9 | 98.9% | A/A | 345 (33%) | 616 (33%) | 961 | 1.040 (0.875, 1.235) |
0.66000 | 0.87660 |
| A/G | 530 (51%) | 914 (49%) | 1444 | ||||||||
| G/G | 168 (16%) | 334 (18%) | 502 | ||||||||
| 29 | 5Q21_1_MG_436 | rs449650 | 5 | 99.1% | G/G | 663 (63%) | 1180 (63%) | 1843 | 1.047 (0.846, 1.294) |
0.67415 | 0.87660 |
| G/T | 339 (32%) | 584 (31%) | 923 | ||||||||
| T/T | 46 (4%) | 103 (6%) | 149 | ||||||||
| 30 | 10Q11_21_MG_456 | rs513391 | 10 | 99.1% | A/A | 742 (71%) | 1310 (70%) | 2052 | 1.048 (0.826, 1.331) |
0.69840 | 0.87660 |
| A/C | 272 (26%) | 513 (27%) | 785 | ||||||||
| C/C | 32 (3%) | 46 (2%) | 78 | ||||||||
| 31 | PSRC1_MG_460 | rs599839 | 1 | 99.3% | A/A | 620 (60%) | 1086 (58%) | 1706 | 1.042 (0.842, 1.290) |
0.70496 | 0.87660 |
| A/G | 361 (35%) | 674 (36%) | 1035 | ||||||||
| G/G | 60 (6%) | 117 (6%) | 177 | ||||||||
| 32 | 5Q21_1_MG_441 | rs565928 | 5 | 99.5% | C/C | 664 (63%) | 1181 (63%) | 1845 | 1.040 (0.841, 1.286) |
0.71768 | 0.87660 |
| C/T | 340 (32%) | 593 (32%) | 933 | ||||||||
| T/T | 46 (4%) | 102 (5%) | 148 | ||||||||
| 33 | CELSR2_MG_438 | rs4970834 | 1 | 99.4% | C/C | 660 (63%) | 1181 (63%) | 1841 | 0.964 (0.775, 1.199) |
0.74151 | 0.87660 |
| C/T | 342 (33%) | 617 (33%) | 959 | ||||||||
| T/T | 45 (4%) | 77 (4%) | 122 | ||||||||
| 34 | 10Q11_21_MG_443 | rs687175 | 10 | 99.4% | C/C | 32 (3%) | 45 (2%) | 77 | 0.961 (0.756, 1.223) |
0.74765 | 0.87660 |
| C/T | 273 (26%) | 515 (27%) | 788 | ||||||||
| T/T | 743 (71%) | 1315 (70%) | 2058 | ||||||||
| 35 | 10Q11_21_MG_428 | rs1746048 | 10 | 99.5% | C/C | 745 (71%) | 1319 (70%) | 2064 | 1.039 (0.817, 1.322) |
0.75386 | 0.87660 |
| C/T | 273 (26%) | 513 (27%) | 786 | ||||||||
| T/T | 31 (3%) | 45 (2%) | 76 | ||||||||
| 36 | 10Q11_21_MG_458 | rs622472 | 10 | 98.4% | A/A | 737 (71%) | 1295 (70%) | 2032 | 1.039 (0.818, 1.319) |
0.75655 | 0.87660 |
| A/C | 268 (26%) | 514 (28%) | 782 | ||||||||
| C/C | 33 (3%) | 47 (3%) | 80 | ||||||||
| 37 | 10Q11_21_MG_440 | rs559580 | 10 | 99.2% | C/C | 32 (3%) | 45 (2%) | 77 | 0.965 (0.759, 1.228) |
0.77225 | 0.87660 |
| C/T | 272 (26%) | 509 (27%) | 781 | ||||||||
| T/T | 744 (71%) | 1314 (70%) | 2058 | ||||||||
| 38 | 10Q11_21_MG_439 | rs501120 | 10 | 96.9% | C/C | 32 (3%) | 44 (2%) | 76 | 0.974 (0.758, 1.252) |
0.83580 | 0.90376 |
| C/T | 249 (24%) | 456 (25%) | 705 | ||||||||
| T/T | 746 (73%) | 1322 (73%) | 2068 | ||||||||
| 39 | SEZ6L_MG_457 | rs6005016 | 22 | 99.0% | A/A | 1 (0%) | 4 (0%) | 5 | 1.045 (0.681, 1.604) |
0.83921 | 0.90376 |
| A/G | 76 (7%) | 126 (7%) | 202 | ||||||||
| G/G | 967 (93%) | 1737 (93%) | 2704 | ||||||||
| 40 | MTHFD1L_MG_445 | rs6922269 | 6 | 99.4% | A/A | 58 (6%) | 99 (5%) | 157 | 1.006 (0.816, 1.241) |
0.95368 | 0.98692 |
| A/G | 387 (37%) | 666 (36%) | 1053 | ||||||||
| G/G | 603 (58%) | 1108 (59%) | 1711 | ||||||||
| 41 | 10Q11_21_MG_432 | rs2146807 | 10 | 99.4% | C/C | 11 (1%) | 15 (1%) | 26 | 1.005 (0.730, 1.386) |
0.97343 | 0.98692 |
| C/T | 175 (17%) | 313 (17%) | 488 | ||||||||
| T/T | 864 (82%) | 1544 (82%) | 2408 | ||||||||
| 42 | 10Q11_21_MG_429 | rs1746049 | 10 | 99.5% | C/C | 798 (76%) | 1425 (76%) | 2223 | 1.002 (0.773, 1.300) |
0.98692 | 0.98692 |
| C/T | 228 (22%) | 425 (23%) | 653 | ||||||||
| T/T | 23 (2%) | 27 (1%) | 50 |
Updated on 2008-12-08
