| rank | SNP | RS-code | Chromosome | Success | Genotype | Cases | Non-cases | Total | HR (95% CI) | nominal p-value | tail-area FDR |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 19Q12_MG_422 | rs11670734 | 19 | 99.5% | C/C | 35 (10%) | 153 (8%) | 188 | 1.266 (1.052, 1.524) |
0.01255 | 0.38452 |
| C/G | 143 (42%) | 818 (41%) | 961 | ||||||||
| G/G | 161 (47%) | 1039 (52%) | 1200 | ||||||||
| 2 | 9P21_3_MG_421 | rs10757283 | 9 | 99.3% | C/C | 83 (24%) | 592 (30%) | 675 | 0.819 (0.694, 0.967) |
0.01831 | 0.38452 |
| C/T | 167 (49%) | 1009 (50%) | 1176 | ||||||||
| T/T | 89 (26%) | 404 (20%) | 493 | ||||||||
| 3 | MTHFD1L_MG_423 | rs12525353 | 6 | 99.4% | A/A | 0 (0%) | 2 (0%) | 2 | 0.403 (0.176, 0.922) |
0.03141 | 0.43976 |
| A/C | 6 (2%) | 79 (4%) | 85 | ||||||||
| C/C | 330 (98%) | 1928 (96%) | 2258 | ||||||||
| 4 | SMAD3_MG_424 | rs12913547 | 15 | 99.6% | C/C | 30 (9%) | 140 (7%) | 170 | 1.177 (0.982, 1.409) |
0.07707 | 0.61877 |
| C/T | 146 (43%) | 785 (39%) | 931 | ||||||||
| T/T | 163 (48%) | 1086 (54%) | 1249 | ||||||||
| 5 | 2Q36_3_MG_447 | rs7597168 | 2 | 99.3% | C/C | 178 (53%) | 1128 (56%) | 1306 | 0.843 (0.695, 1.023) |
0.08325 | 0.61877 |
| C/T | 129 (38%) | 765 (38%) | 894 | ||||||||
| T/T | 30 (9%) | 114 (6%) | 144 | ||||||||
| 6 | 19Q12_MG_446 | rs7250581 | 19 | 98.0% | A/A | 13 (4%) | 49 (2%) | 62 | 1.220 (0.971, 1.533) |
0.08840 | 0.61877 |
| A/G | 84 (25%) | 464 (23%) | 548 | ||||||||
| G/G | 237 (71%) | 1465 (74%) | 1702 | ||||||||
| 7 | MIA3_MG_454 | rs3008621 | 1 | 98.5% | A/A | 7 (2%) | 52 (3%) | 59 | 0.831 (0.654, 1.055) |
0.12899 | 0.68378 |
| A/G | 74 (22%) | 483 (24%) | 557 | ||||||||
| G/G | 253 (76%) | 1456 (73%) | 1709 | ||||||||
| 8 | 9P21_3_MG_425 | rs1333049 | 9 | 99.6% | C/C | 60 (18%) | 341 (17%) | 401 | 1.128 (0.955, 1.332) |
0.15695 | 0.68378 |
| C/G | 173 (51%) | 981 (49%) | 1154 | ||||||||
| G/G | 106 (31%) | 689 (34%) | 795 | ||||||||
| 9 | SEZ6L_MG_442 | rs6005015 | 22 | 99.5% | C/C | 23 (7%) | 183 (9%) | 206 | 0.876 (0.727, 1.057) |
0.16726 | 0.68378 |
| C/T | 145 (43%) | 868 (43%) | 1013 | ||||||||
| T/T | 171 (50%) | 959 (48%) | 1130 | ||||||||
| 10 | 5Q21_1_MG_436 | rs449650 | 5 | 99.1% | G/G | 194 (57%) | 1266 (63%) | 1460 | 0.886 (0.736, 1.066) |
0.19971 | 0.68378 |
| G/T | 125 (37%) | 626 (31%) | 751 | ||||||||
| T/T | 19 (6%) | 108 (5%) | 127 | ||||||||
| 11 | 9P21_3_MG_420 | rs10738610 | 9 | 99.2% | A/A | 105 (31%) | 669 (33%) | 774 | 0.897 (0.760, 1.059) |
0.19994 | 0.68378 |
| A/C | 173 (51%) | 982 (49%) | 1155 | ||||||||
| C/C | 61 (18%) | 351 (18%) | 412 | ||||||||
| 12 | 5Q21_1_MG_455 | rs383830 | 5 | 99.0% | A/A | 18 (5%) | 106 (5%) | 124 | 1.129 (0.936, 1.360) |
0.20416 | 0.68378 |
| A/T | 125 (37%) | 629 (31%) | 754 | ||||||||
| T/T | 192 (57%) | 1266 (63%) | 1458 | ||||||||
| 13 | 5Q21_1_MG_441 | rs565928 | 5 | 99.5% | C/C | 195 (58%) | 1267 (63%) | 1462 | 0.889 (0.738, 1.072) |
0.21759 | 0.68378 |
| C/T | 125 (37%) | 635 (32%) | 760 | ||||||||
| T/T | 19 (6%) | 107 (5%) | 126 | ||||||||
| 14 | 5Q21_1_MG_435 | rs436495 | 5 | 98.8% | A/A | 26 (8%) | 117 (6%) | 143 | 1.122 (0.930, 1.354) |
0.22793 | 0.68378 |
| A/G | 126 (37%) | 695 (35%) | 821 | ||||||||
| G/G | 185 (55%) | 1183 (59%) | 1368 | ||||||||
| 15 | MTHFD1L_MG_445 | rs6922269 | 6 | 99.3% | A/A | 21 (6%) | 104 (5%) | 125 | 1.099 (0.901, 1.341) |
0.35126 | 0.96309 |
| A/G | 118 (35%) | 711 (35%) | 829 | ||||||||
| G/G | 199 (59%) | 1191 (59%) | 1390 | ||||||||
| 16 | PSRC1_MG_460 | rs599839 | 1 | 99.4% | A/A | 205 (61%) | 1162 (58%) | 1367 | 1.095 (0.899, 1.335) |
0.36689 | 0.96309 |
| A/G | 111 (33%) | 721 (36%) | 832 | ||||||||
| G/G | 21 (6%) | 127 (6%) | 148 | ||||||||
| 17 | SEZ6L_MG_444 | rs688034 | 22 | 99.5% | C/C | 193 (57%) | 1037 (52%) | 1230 | 1.087 (0.893, 1.324) |
0.40511 | 0.96455 |
| C/T | 122 (36%) | 832 (41%) | 954 | ||||||||
| T/T | 24 (7%) | 140 (7%) | 164 | ||||||||
| 18 | 10Q11_21_MG_432 | rs2146807 | 10 | 99.3% | C/C | 1 (0%) | 15 (1%) | 16 | 0.885 (0.650, 1.204) |
0.43659 | 0.96455 |
| C/T | 50 (15%) | 332 (17%) | 382 | ||||||||
| T/T | 288 (85%) | 1658 (83%) | 1946 | ||||||||
| 19 | CELSR2_MG_434 | rs413380 | 1 | 99.5% | C/C | 310 (91%) | 1825 (91%) | 2135 | 1.122 (0.776, 1.622) |
0.54157 | 0.96455 |
| C/T | 29 (9%) | 175 (9%) | 204 | ||||||||
| T/T | 0 (0%) | 10 (0%) | 10 | ||||||||
| 20 | SEZ6L_MG_457 | rs6005016 | 22 | 98.9% | A/A | 0 (0%) | 4 (0%) | 4 | 0.906 (0.592, 1.387) |
0.65072 | 0.96455 |
| A/G | 23 (7%) | 137 (7%) | 160 | ||||||||
| G/G | 312 (93%) | 1858 (93%) | 2170 | ||||||||
| 21 | 1Q31_2_MG_453 | rs1936982 | 1 | 99.0% | C/C | 41 (12%) | 253 (13%) | 294 | 0.961 (0.809, 1.143) |
0.65564 | 0.96455 |
| C/T | 143 (43%) | 878 (44%) | 1021 | ||||||||
| T/T | 150 (45%) | 871 (44%) | 1021 | ||||||||
| 22 | FMN2_MG_450 | rs1456648 | 1 | 98.5% | G/G | 4 (1%) | 49 (2%) | 53 | 0.954 (0.763, 1.192) |
0.67661 | 0.96455 |
| G/T | 92 (28%) | 515 (26%) | 607 | ||||||||
| T/T | 237 (71%) | 1428 (72%) | 1665 | ||||||||
| 23 | 9P21_3_MG_451 | rs1537378 | 9 | 98.0% | A/A | 40 (12%) | 295 (15%) | 335 | 0.966 (0.818, 1.139) |
0.67905 | 0.96455 |
| A/G | 175 (53%) | 956 (48%) | 1131 | ||||||||
| G/G | 116 (35%) | 731 (37%) | 847 | ||||||||
| 24 | SEZ6L_MG_426 | rs137205 | 22 | 99.4% | A/A | 27 (8%) | 158 (8%) | 185 | 0.963 (0.798, 1.162) |
0.69529 | 0.96455 |
| A/G | 137 (41%) | 871 (43%) | 1008 | ||||||||
| G/G | 174 (51%) | 980 (49%) | 1154 | ||||||||
| 25 | 12Q12_MG_448 | rs7970834 | 12 | 99.5% | G/G | 102 (30%) | 627 (31%) | 729 | 0.967 (0.814, 1.148) |
0.69889 | 0.96455 |
| G/T | 171 (51%) | 1014 (50%) | 1185 | ||||||||
| T/T | 65 (19%) | 369 (18%) | 434 | ||||||||
| 26 | SMAD3_MG_431 | rs1866317 | 15 | 99.5% | C/C | 5 (1%) | 30 (1%) | 35 | 1.046 (0.827, 1.324) |
0.70614 | 0.96455 |
| C/G | 88 (26%) | 475 (24%) | 563 | ||||||||
| G/G | 246 (73%) | 1505 (75%) | 1751 | ||||||||
| 27 | 10Q11_21_MG_458 | rs622472 | 10 | 98.3% | A/A | 239 (72%) | 1389 (70%) | 1628 | 1.042 (0.823, 1.319) |
0.73154 | 0.96455 |
| A/C | 82 (25%) | 546 (27%) | 628 | ||||||||
| C/C | 13 (4%) | 51 (3%) | 64 | ||||||||
| 28 | CELSR2_MG_438 | rs4970834 | 1 | 99.4% | C/C | 221 (65%) | 1261 (63%) | 1482 | 1.036 (0.834, 1.287) |
0.74873 | 0.96455 |
| C/T | 97 (29%) | 664 (33%) | 761 | ||||||||
| T/T | 20 (6%) | 83 (4%) | 103 | ||||||||
| 29 | 2Q36_3_MG_433 | rs2972147 | 2 | 98.4% | C/C | 133 (40%) | 805 (40%) | 938 | 1.025 (0.866, 1.213) |
0.77795 | 0.96455 |
| C/T | 159 (48%) | 913 (46%) | 1072 | ||||||||
| T/T | 40 (12%) | 272 (14%) | 312 | ||||||||
| 30 | MTHFD1L_MG_449 | rs12214306 | 6 | 99.1% | C/C | 1 (0%) | 1 (0%) | 2 | 0.930 (0.530, 1.632) |
0.80142 | 0.96455 |
| C/T | 15 (4%) | 96 (5%) | 111 | ||||||||
| T/T | 319 (95%) | 1907 (95%) | 2226 | ||||||||
| 31 | 10Q11_21_MG_440 | rs559580 | 10 | 99.1% | C/C | 13 (4%) | 49 (2%) | 62 | 0.973 (0.768, 1.233) |
0.82149 | 0.96455 |
| C/T | 82 (24%) | 542 (27%) | 624 | ||||||||
| T/T | 242 (72%) | 1410 (70%) | 1652 | ||||||||
| 32 | 10Q11_21_MG_456 | rs513391 | 10 | 99.0% | A/A | 240 (72%) | 1406 (70%) | 1646 | 1.028 (0.811, 1.302) |
0.82158 | 0.96455 |
| A/C | 82 (24%) | 546 (27%) | 628 | ||||||||
| C/C | 13 (4%) | 50 (2%) | 63 | ||||||||
| 33 | 10Q11_21_MG_443 | rs687175 | 10 | 99.4% | C/C | 13 (4%) | 49 (2%) | 62 | 0.974 (0.769, 1.233) |
0.82657 | 0.96455 |
| C/T | 83 (24%) | 548 (27%) | 631 | ||||||||
| T/T | 243 (72%) | 1411 (70%) | 1654 | ||||||||
| 34 | SMAD3_MG_452 | rs17228212 | 15 | 99.1% | C/C | 19 (6%) | 107 (5%) | 126 | 1.021 (0.832, 1.253) |
0.84223 | 0.96455 |
| C/T | 114 (34%) | 727 (36%) | 841 | ||||||||
| T/T | 202 (60%) | 1169 (58%) | 1371 | ||||||||
| 35 | 10Q11_21_MG_439 | rs501120 | 10 | 96.6% | C/C | 13 (4%) | 48 (2%) | 61 | 0.977 (0.766, 1.248) |
0.85496 | 0.96455 |
| C/T | 71 (22%) | 486 (25%) | 557 | ||||||||
| T/T | 244 (74%) | 1418 (73%) | 1662 | ||||||||
| 36 | 10Q11_21_MG_428 | rs1746048 | 10 | 99.5% | C/C | 243 (72%) | 1415 (70%) | 1658 | 1.021 (0.806, 1.293) |
0.86251 | 0.96455 |
| C/T | 83 (24%) | 546 (27%) | 629 | ||||||||
| T/T | 13 (4%) | 48 (2%) | 61 | ||||||||
| 37 | 2Q36_3_MG_461 | rs2943634 | 2 | 97.2% | A/A | 41 (12%) | 247 (13%) | 288 | 1.015 (0.855, 1.204) |
0.86777 | 0.96455 |
| A/C | 153 (47%) | 893 (45%) | 1046 | ||||||||
| C/C | 135 (41%) | 824 (42%) | 959 | ||||||||
| 38 | SEZ6L_MG_427 | rs137209 | 22 | 99.6% | A/A | 35 (10%) | 204 (10%) | 239 | 0.987 (0.824, 1.184) |
0.89094 | 0.96455 |
| A/G | 150 (44%) | 928 (46%) | 1078 | ||||||||
| G/G | 154 (45%) | 879 (44%) | 1033 | ||||||||
| 39 | 9P21_3_MG_459 | rs7865618 | 9 | 98.8% | A/A | 103 (31%) | 653 (33%) | 756 | 0.990 (0.841, 1.164) |
0.89876 | 0.96455 |
| A/G | 173 (52%) | 976 (49%) | 1149 | ||||||||
| G/G | 58 (17%) | 368 (18%) | 426 | ||||||||
| 40 | 9P21_3_MG_437 | rs496892 | 9 | 98.8% | C/C | 82 (24%) | 503 (25%) | 585 | 1.007 (0.854, 1.188) |
0.93284 | 0.96455 |
| C/T | 178 (53%) | 1028 (51%) | 1206 | ||||||||
| T/T | 75 (22%) | 466 (23%) | 541 | ||||||||
| 41 | 10Q11_21_MG_429 | rs1746049 | 10 | 99.5% | C/C | 259 (76%) | 1530 (76%) | 1789 | 0.991 (0.769, 1.279) |
0.94750 | 0.96455 |
| C/T | 72 (21%) | 449 (22%) | 521 | ||||||||
| T/T | 8 (2%) | 31 (2%) | 39 | ||||||||
| 42 | MIA3_MG_430 | rs17465637 | 1 | 99.2% | A/A | 29 (9%) | 149 (7%) | 178 | 0.996 (0.823, 1.205) |
0.96455 | 0.96455 |
| A/C | 117 (35%) | 738 (37%) | 855 | ||||||||
| C/C | 191 (57%) | 1117 (56%) | 1308 |
Updated on 2008-12-08
