Cox regression for DEATH endpoint, test for multiplicative allele effects, men and women

rank SNP RS-code Chromosome Success Genotype Cases Non-cases Total HR (95% CI) nominal p-value tail-area FDR
1 19Q12_MG_422 rs11670734 19 99.5% C/C 138 (10%) 145 (8%) 283 1.189
(1.063, 1.329)		 0.00243 0.10217
C/G 599 (42%) 732 (41%) 1331
G/G 706 (49%) 919 (51%) 1625
2 MTHFD1L_MG_423 rs12525353 6 99.4% A/A 1 (0%) 2 (0%) 3 0.643
(0.436, 0.949)		 0.02599 0.54589
A/C 36 (2%) 71 (4%) 107
C/C 1403 (97%) 1722 (96%) 3125
3 19Q12_MG_446 rs7250581 19 98.1% A/A 49 (3%) 45 (3%) 94 1.154
(1.007, 1.323)		 0.03932 0.55048
A/G 354 (25%) 419 (24%) 773
G/G 1025 (72%) 1303 (74%) 2328
4 SMAD3_MG_424 rs12913547 15 99.5% C/C 115 (8%) 129 (7%) 244 1.111
(0.995, 1.241)		 0.06248 0.65609
C/T 613 (43%) 695 (39%) 1308
T/T 714 (50%) 973 (54%) 1687
5 PSRC1_MG_460 rs599839 1 99.6% A/A 853 (59%) 1036 (58%) 1889 1.096
(0.978, 1.229)		 0.11473 0.88488
A/G 516 (36%) 641 (36%) 1157
G/G 80 (6%) 116 (6%) 196
6 CELSR2_MG_438 rs4970834 1 99.4% C/C 922 (64%) 1125 (63%) 2047 1.077
(0.949, 1.221)		 0.25191 0.88488
C/T 447 (31%) 593 (33%) 1040
T/T 72 (5%) 76 (4%) 148
7 MTHFD1L_MG_449 rs12214306 6 99.1% C/C 1 (0%) 1 (0%) 2 0.827
(0.596, 1.148)		 0.25606 0.88488
C/T 64 (4%) 88 (5%) 152
T/T 1376 (95%) 1698 (95%) 3074
8 SEZ6L_MG_442 rs6005015 22 99.4% C/C 130 (9%) 165 (9%) 295 0.942
(0.843, 1.053)		 0.29205 0.88488
C/T 606 (42%) 767 (43%) 1373
T/T 705 (49%) 864 (48%) 1569
9 12Q12_MG_448 rs7970834 12 99.4% G/G 448 (31%) 559 (31%) 1007 0.952
(0.858, 1.057)		 0.35743 0.88488
G/T 692 (48%) 907 (51%) 1599
T/T 302 (21%) 330 (18%) 632
10 SMAD3_MG_452 rs17228212 15 99.1% C/C 61 (4%) 95 (5%) 156 0.946
(0.839, 1.067)		 0.36922 0.88488
C/T 488 (34%) 650 (36%) 1138
T/T 892 (62%) 1041 (58%) 1933
11 9P21_3_MG_437 rs496892 9 98.9% C/C 359 (25%) 449 (25%) 808 0.956
(0.864, 1.057)		 0.37591 0.88488
C/T 713 (50%) 914 (51%) 1627
T/T 363 (25%) 421 (24%) 784
12 10Q11_21_MG_439 rs501120 10 96.7% C/C 41 (3%) 45 (3%) 86 1.057
(0.921, 1.213)		 0.43008 0.88488
C/T 368 (26%) 433 (25%) 801
T/T 994 (71%) 1268 (73%) 2262
13 SEZ6L_MG_457 rs6005016 22 99.0% A/A 2 (0%) 3 (0%) 5 0.902
(0.697, 1.166)		 0.43099 0.88488
A/G 93 (6%) 129 (7%) 222
G/G 1346 (93%) 1650 (93%) 2996
14 10Q11_21_MG_429 rs1746049 10 99.5% C/C 1078 (75%) 1367 (76%) 2445 0.947
(0.818, 1.096)		 0.46132 0.88488
C/T 341 (24%) 399 (22%) 740
T/T 25 (2%) 30 (2%) 55
15 MTHFD1L_MG_445 rs6922269 6 99.2% A/A 84 (6%) 93 (5%) 177 1.044
(0.928, 1.174)		 0.47307 0.88488
A/G 510 (35%) 635 (35%) 1145
G/G 845 (59%) 1064 (59%) 1909
16 SMAD3_MG_431 rs1866317 15 99.5% C/C 28 (2%) 27 (2%) 55 1.051
(0.912, 1.211)		 0.49311 0.88488
C/G 371 (26%) 411 (23%) 782
G/G 1045 (72%) 1358 (76%) 2403
17 9P21_3_MG_451 rs1537378 9 97.9% A/A 211 (15%) 271 (15%) 482 1.034
(0.934, 1.145)		 0.52226 0.88488
A/G 716 (50%) 832 (47%) 1548
G/G 495 (35%) 662 (38%) 1157
18 10Q11_21_MG_432 rs2146807 10 99.3% C/C 13 (1%) 14 (1%) 27 1.056
(0.884, 1.262)		 0.54563 0.88488
C/T 238 (17%) 299 (17%) 537
T/T 1190 (83%) 1480 (83%) 2670
19 9P21_3_MG_420 rs10738610 9 99.2% A/A 477 (33%) 596 (33%) 1073 0.971
(0.879, 1.073)		 0.56749 0.88488
A/C 722 (50%) 875 (49%) 1597
C/C 243 (17%) 317 (18%) 560
20 FMN2_MG_450 rs1456648 1 98.6% G/G 33 (2%) 45 (3%) 78 0.961
(0.838, 1.102)		 0.57056 0.88488
G/T 364 (25%) 461 (26%) 825
T/T 1037 (72%) 1270 (72%) 2307
21 MIA3_MG_430 rs17465637 1 99.1% A/A 112 (8%) 128 (7%) 240 0.968
(0.866, 1.083)		 0.57154 0.88488
A/C 501 (35%) 666 (37%) 1167
C/C 822 (57%) 997 (56%) 1819
22 9P21_3_MG_425 rs1333049 9 99.5% C/C 235 (16%) 308 (17%) 543 1.027
(0.929, 1.135)		 0.59924 0.88488
C/G 722 (50%) 873 (49%) 1595
G/G 487 (34%) 616 (34%) 1103
23 5Q21_1_MG_455 rs383830 5 99.0% A/A 64 (4%) 92 (5%) 156 1.031
(0.918, 1.158)		 0.60369 0.88488
A/T 501 (35%) 559 (31%) 1060
T/T 876 (61%) 1133 (64%) 2009
24 5Q21_1_MG_436 rs449650 5 99.1% G/G 875 (61%) 1137 (64%) 2012 0.971
(0.865, 1.090)		 0.61820 0.88488
G/T 501 (35%) 556 (31%) 1057
T/T 64 (4%) 94 (5%) 158
25 9P21_3_MG_459 rs7865618 9 98.8% A/A 459 (32%) 584 (33%) 1043 0.976
(0.884, 1.077)		 0.62672 0.88488
A/G 701 (49%) 862 (48%) 1563
G/G 277 (19%) 334 (19%) 611
26 5Q21_1_MG_441 rs565928 5 99.4% C/C 877 (61%) 1137 (63%) 2014 0.972
(0.866, 1.091)		 0.62814 0.88488
C/T 502 (35%) 565 (31%) 1067
T/T 64 (4%) 93 (5%) 157
27 10Q11_21_MG_456 rs513391 10 99.1% A/A 992 (69%) 1252 (70%) 2244 0.968
(0.848, 1.107)		 0.63707 0.88488
A/C 406 (28%) 487 (27%) 893
C/C 43 (3%) 46 (3%) 89
28 CELSR2_MG_434 rs413380 1 99.5% C/C 1316 (91%) 1633 (91%) 2949 1.052
(0.846, 1.307)		 0.64966 0.88488
C/T 124 (9%) 155 (9%) 279
T/T 4 (0%) 8 (0%) 12
29 MIA3_MG_454 rs3008621 1 98.6% A/A 34 (2%) 43 (2%) 77 0.970
(0.849, 1.108)		 0.65123 0.88488
A/G 367 (26%) 429 (24%) 796
G/G 1034 (72%) 1302 (73%) 2336
30 10Q11_21_MG_440 rs559580 10 99.0% C/C 39 (3%) 46 (3%) 85 1.030
(0.901, 1.177)		 0.66485 0.88488
C/T 408 (28%) 483 (27%) 891
T/T 988 (69%) 1260 (70%) 2248
31 1Q31_2_MG_453 rs1936982 1 99.0% C/C 167 (12%) 233 (13%) 400 0.978
(0.884, 1.082)		 0.66668 0.88488
C/T 645 (45%) 774 (43%) 1419
T/T 628 (44%) 778 (44%) 1406
32 10Q11_21_MG_428 rs1746048 10 99.4% C/C 994 (69%) 1263 (70%) 2257 0.974
(0.853, 1.114)		 0.70312 0.88488
C/T 410 (28%) 487 (27%) 897
T/T 39 (3%) 45 (3%) 84
33 10Q11_21_MG_443 rs687175 10 99.4% C/C 40 (3%) 46 (3%) 86 1.025
(0.897, 1.171)		 0.71550 0.88488
C/T 409 (28%) 489 (27%) 898
T/T 993 (69%) 1260 (70%) 2253
34 SEZ6L_MG_427 rs137209 22 99.5% A/A 154 (11%) 181 (10%) 335 0.981
(0.882, 1.090)		 0.72086 0.88488
A/G 633 (44%) 833 (46%) 1466
G/G 656 (45%) 783 (44%) 1439
35 SEZ6L_MG_426 rs137205 22 99.4% A/A 120 (8%) 140 (8%) 260 0.982
(0.881, 1.095)		 0.74205 0.88488
A/G 593 (41%) 785 (44%) 1378
G/G 729 (51%) 870 (48%) 1599
36 2Q36_3_MG_433 rs2972147 2 98.5% C/C 571 (40%) 726 (41%) 1297 0.985
(0.890, 1.092)		 0.77879 0.88488
C/T 668 (47%) 809 (46%) 1477
T/T 192 (13%) 241 (14%) 433
37 2Q36_3_MG_461 rs2943634 2 97.4% A/A 179 (13%) 219 (13%) 398 0.985
(0.887, 1.094)		 0.77953 0.88488
A/C 637 (45%) 793 (45%) 1430
C/C 603 (42%) 739 (42%) 1342
38 9P21_3_MG_421 rs10757283 9 99.3% C/C 407 (28%) 533 (30%) 940 0.990
(0.896, 1.093)		 0.83580 0.91615
C/T 725 (50%) 890 (50%) 1615
T/T 311 (22%) 368 (21%) 679
39 2Q36_3_MG_447 rs7597168 2 99.4% C/C 811 (56%) 1013 (56%) 1824 0.989
(0.879, 1.112)		 0.85072 0.91615
C/T 535 (37%) 677 (38%) 1212
T/T 95 (7%) 104 (6%) 199
40 SEZ6L_MG_444 rs688034 22 99.5% C/C 775 (54%) 918 (51%) 1693 1.008
(0.900, 1.128)		 0.89206 0.93667
C/T 564 (39%) 749 (42%) 1313
T/T 105 (7%) 128 (7%) 233
41 10Q11_21_MG_458 rs622472 10 98.3% A/A 988 (69%) 1235 (70%) 2223 0.994
(0.870, 1.136)		 0.92940 0.94052
A/C 399 (28%) 488 (28%) 887
C/C 43 (3%) 47 (3%) 90
42 5Q21_1_MG_435 rs436495 5 98.7% A/A 77 (5%) 103 (6%) 180 0.996
(0.889, 1.116)		 0.94052 0.94052
A/G 522 (36%) 618 (35%) 1140
G/G 835 (58%) 1060 (60%) 1895

stratified by sex, adjusted for: cohort nonhdl hdla bmi bpm dsmoker hisdiab1

Updated on 2008-12-08