| rank | SNP | RS-code | Chromosome | Success | Genotype | Cases | Non-cases | Total | HR (95% CI) | nominal p-value | tail-area FDR |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 19Q12_MG_422 | rs11670734 | 19 | 99.5% | C/C | 138 (10%) | 145 (8%) | 283 | 1.198 (1.074, 1.337) |
0.00120 | 0.05041 |
| C/G | 599 (42%) | 732 (41%) | 1331 | ||||||||
| G/G | 706 (49%) | 919 (51%) | 1625 | ||||||||
| 2 | MTHFD1L_MG_423 | rs12525353 | 6 | 99.4% | A/A | 1 (0%) | 2 (0%) | 3 | 0.619 (0.422, 0.909) |
0.01445 | 0.30344 |
| A/C | 36 (2%) | 71 (4%) | 107 | ||||||||
| C/C | 1403 (97%) | 1722 (96%) | 3125 | ||||||||
| 3 | 19Q12_MG_446 | rs7250581 | 19 | 98.1% | A/A | 49 (3%) | 45 (3%) | 94 | 1.159 (1.013, 1.326) |
0.03131 | 0.33883 |
| A/G | 354 (25%) | 419 (24%) | 773 | ||||||||
| G/G | 1025 (72%) | 1303 (74%) | 2328 | ||||||||
| 4 | SMAD3_MG_424 | rs12913547 | 15 | 99.5% | C/C | 115 (8%) | 129 (7%) | 244 | 1.125 (1.010, 1.254) |
0.03227 | 0.33883 |
| C/T | 613 (43%) | 695 (39%) | 1308 | ||||||||
| T/T | 714 (50%) | 973 (54%) | 1687 | ||||||||
| 5 | PSRC1_MG_460 | rs599839 | 1 | 99.6% | A/A | 853 (59%) | 1036 (58%) | 1889 | 1.070 (0.957, 1.195) |
0.23467 | 0.80289 |
| A/G | 516 (36%) | 641 (36%) | 1157 | ||||||||
| G/G | 80 (6%) | 116 (6%) | 196 | ||||||||
| 6 | SMAD3_MG_452 | rs17228212 | 15 | 99.1% | C/C | 61 (4%) | 95 (5%) | 156 | 0.934 (0.830, 1.051) |
0.25561 | 0.80289 |
| C/T | 488 (34%) | 650 (36%) | 1138 | ||||||||
| T/T | 892 (62%) | 1041 (58%) | 1933 | ||||||||
| 7 | 10Q11_21_MG_439 | rs501120 | 10 | 96.7% | C/C | 41 (3%) | 45 (3%) | 86 | 1.076 (0.941, 1.230) |
0.28499 | 0.80289 |
| C/T | 368 (26%) | 433 (25%) | 801 | ||||||||
| T/T | 994 (71%) | 1268 (73%) | 2262 | ||||||||
| 8 | MTHFD1L_MG_449 | rs12214306 | 6 | 99.1% | C/C | 1 (0%) | 1 (0%) | 2 | 0.848 (0.613, 1.172) |
0.31734 | 0.80289 |
| C/T | 64 (4%) | 88 (5%) | 152 | ||||||||
| T/T | 1376 (95%) | 1698 (95%) | 3074 | ||||||||
| 9 | 9P21_3_MG_437 | rs496892 | 9 | 98.9% | C/C | 359 (25%) | 449 (25%) | 808 | 0.952 (0.863, 1.049) |
0.32122 | 0.80289 |
| C/T | 713 (50%) | 914 (51%) | 1627 | ||||||||
| T/T | 363 (25%) | 421 (24%) | 784 | ||||||||
| 10 | MTHFD1L_MG_445 | rs6922269 | 6 | 99.2% | A/A | 84 (6%) | 93 (5%) | 177 | 1.057 (0.942, 1.186) |
0.34329 | 0.80289 |
| A/G | 510 (35%) | 635 (35%) | 1145 | ||||||||
| G/G | 845 (59%) | 1064 (59%) | 1909 | ||||||||
| 11 | SMAD3_MG_431 | rs1866317 | 15 | 99.5% | C/C | 28 (2%) | 27 (2%) | 55 | 1.069 (0.930, 1.228) |
0.34617 | 0.80289 |
| C/G | 371 (26%) | 411 (23%) | 782 | ||||||||
| G/G | 1045 (72%) | 1358 (76%) | 2403 | ||||||||
| 12 | 10Q11_21_MG_429 | rs1746049 | 10 | 99.5% | C/C | 1078 (75%) | 1367 (76%) | 2445 | 0.937 (0.812, 1.082) |
0.37684 | 0.80289 |
| C/T | 341 (24%) | 399 (22%) | 740 | ||||||||
| T/T | 25 (2%) | 30 (2%) | 55 | ||||||||
| 13 | FMN2_MG_450 | rs1456648 | 1 | 98.6% | G/G | 33 (2%) | 45 (3%) | 78 | 0.944 (0.826, 1.079) |
0.39863 | 0.80289 |
| G/T | 364 (25%) | 461 (26%) | 825 | ||||||||
| T/T | 1037 (72%) | 1270 (72%) | 2307 | ||||||||
| 14 | 9P21_3_MG_451 | rs1537378 | 9 | 97.9% | A/A | 211 (15%) | 271 (15%) | 482 | 1.043 (0.945, 1.153) |
0.40280 | 0.80289 |
| A/G | 716 (50%) | 832 (47%) | 1548 | ||||||||
| G/G | 495 (35%) | 662 (38%) | 1157 | ||||||||
| 15 | 12Q12_MG_448 | rs7970834 | 12 | 99.4% | G/G | 448 (31%) | 559 (31%) | 1007 | 0.958 (0.866, 1.060) |
0.40681 | 0.80289 |
| G/T | 692 (48%) | 907 (51%) | 1599 | ||||||||
| T/T | 302 (21%) | 330 (18%) | 632 | ||||||||
| 16 | SEZ6L_MG_442 | rs6005015 | 22 | 99.4% | C/C | 130 (9%) | 165 (9%) | 295 | 0.957 (0.858, 1.067) |
0.42918 | 0.80289 |
| C/T | 606 (42%) | 767 (43%) | 1373 | ||||||||
| T/T | 705 (49%) | 864 (48%) | 1569 | ||||||||
| 17 | 10Q11_21_MG_456 | rs513391 | 10 | 99.1% | A/A | 992 (69%) | 1252 (70%) | 2244 | 0.950 (0.834, 1.083) |
0.44419 | 0.80289 |
| A/C | 406 (28%) | 487 (27%) | 893 | ||||||||
| C/C | 43 (3%) | 46 (3%) | 89 | ||||||||
| 18 | 9P21_3_MG_420 | rs10738610 | 9 | 99.2% | A/A | 477 (33%) | 596 (33%) | 1073 | 0.963 (0.873, 1.062) |
0.45043 | 0.80289 |
| A/C | 722 (50%) | 875 (49%) | 1597 | ||||||||
| C/C | 243 (17%) | 317 (18%) | 560 | ||||||||
| 19 | 9P21_3_MG_425 | rs1333049 | 9 | 99.5% | C/C | 235 (16%) | 308 (17%) | 543 | 1.038 (0.941, 1.145) |
0.45431 | 0.80289 |
| C/G | 722 (50%) | 873 (49%) | 1595 | ||||||||
| G/G | 487 (34%) | 616 (34%) | 1103 | ||||||||
| 20 | 10Q11_21_MG_440 | rs559580 | 10 | 99.0% | C/C | 39 (3%) | 46 (3%) | 85 | 1.048 (0.920, 1.195) |
0.47766 | 0.80289 |
| C/T | 408 (28%) | 483 (27%) | 891 | ||||||||
| T/T | 988 (69%) | 1260 (70%) | 2248 | ||||||||
| 21 | CELSR2_MG_438 | rs4970834 | 1 | 99.4% | C/C | 922 (64%) | 1125 (63%) | 2047 | 1.045 (0.924, 1.181) |
0.48508 | 0.80289 |
| C/T | 447 (31%) | 593 (33%) | 1040 | ||||||||
| T/T | 72 (5%) | 76 (4%) | 148 | ||||||||
| 22 | 10Q11_21_MG_428 | rs1746048 | 10 | 99.4% | C/C | 994 (69%) | 1263 (70%) | 2257 | 0.955 (0.838, 1.088) |
0.48603 | 0.80289 |
| C/T | 410 (28%) | 487 (27%) | 897 | ||||||||
| T/T | 39 (3%) | 45 (3%) | 84 | ||||||||
| 23 | 10Q11_21_MG_432 | rs2146807 | 10 | 99.3% | C/C | 13 (1%) | 14 (1%) | 27 | 1.063 (0.894, 1.265) |
0.48821 | 0.80289 |
| C/T | 238 (17%) | 299 (17%) | 537 | ||||||||
| T/T | 1190 (83%) | 1480 (83%) | 2670 | ||||||||
| 24 | 1Q31_2_MG_453 | rs1936982 | 1 | 99.0% | C/C | 167 (12%) | 233 (13%) | 400 | 0.966 (0.875, 1.067) |
0.50087 | 0.80289 |
| C/T | 645 (45%) | 774 (43%) | 1419 | ||||||||
| T/T | 628 (44%) | 778 (44%) | 1406 | ||||||||
| 25 | 9P21_3_MG_459 | rs7865618 | 9 | 98.8% | A/A | 459 (32%) | 584 (33%) | 1043 | 0.968 (0.879, 1.066) |
0.50892 | 0.80289 |
| A/G | 701 (49%) | 862 (48%) | 1563 | ||||||||
| G/G | 277 (19%) | 334 (19%) | 611 | ||||||||
| 26 | SEZ6L_MG_457 | rs6005016 | 22 | 99.0% | A/A | 2 (0%) | 3 (0%) | 5 | 0.919 (0.713, 1.183) |
0.50990 | 0.80289 |
| A/G | 93 (6%) | 129 (7%) | 222 | ||||||||
| G/G | 1346 (93%) | 1650 (93%) | 2996 | ||||||||
| 27 | 10Q11_21_MG_443 | rs687175 | 10 | 99.4% | C/C | 40 (3%) | 46 (3%) | 86 | 1.044 (0.916, 1.190) |
0.51615 | 0.80289 |
| C/T | 409 (28%) | 489 (27%) | 898 | ||||||||
| T/T | 993 (69%) | 1260 (70%) | 2253 | ||||||||
| 28 | 5Q21_1_MG_455 | rs383830 | 5 | 99.0% | A/A | 64 (4%) | 92 (5%) | 156 | 1.028 (0.918, 1.152) |
0.63177 | 0.87995 |
| A/T | 501 (35%) | 559 (31%) | 1060 | ||||||||
| T/T | 876 (61%) | 1133 (64%) | 2009 | ||||||||
| 29 | CELSR2_MG_434 | rs413380 | 1 | 99.5% | C/C | 1316 (91%) | 1633 (91%) | 2949 | 1.053 (0.850, 1.304) |
0.63793 | 0.87995 |
| C/T | 124 (9%) | 155 (9%) | 279 | ||||||||
| T/T | 4 (0%) | 8 (0%) | 12 | ||||||||
| 30 | 5Q21_1_MG_436 | rs449650 | 5 | 99.1% | G/G | 875 (61%) | 1137 (64%) | 2012 | 0.973 (0.869, 1.090) |
0.63841 | 0.87995 |
| G/T | 501 (35%) | 556 (31%) | 1057 | ||||||||
| T/T | 64 (4%) | 94 (5%) | 158 | ||||||||
| 31 | 5Q21_1_MG_441 | rs565928 | 5 | 99.4% | C/C | 877 (61%) | 1137 (63%) | 2014 | 0.975 (0.871, 1.093) |
0.66743 | 0.87995 |
| C/T | 502 (35%) | 565 (31%) | 1067 | ||||||||
| T/T | 64 (4%) | 93 (5%) | 157 | ||||||||
| 32 | MIA3_MG_430 | rs17465637 | 1 | 99.1% | A/A | 112 (8%) | 128 (7%) | 240 | 0.978 (0.877, 1.091) |
0.68920 | 0.87995 |
| A/C | 501 (35%) | 666 (37%) | 1167 | ||||||||
| C/C | 822 (57%) | 997 (56%) | 1819 | ||||||||
| 33 | 9P21_3_MG_421 | rs10757283 | 9 | 99.3% | C/C | 407 (28%) | 533 (30%) | 940 | 0.981 (0.890, 1.081) |
0.69591 | 0.87995 |
| C/T | 725 (50%) | 890 (50%) | 1615 | ||||||||
| T/T | 311 (22%) | 368 (21%) | 679 | ||||||||
| 34 | 10Q11_21_MG_458 | rs622472 | 10 | 98.3% | A/A | 988 (69%) | 1235 (70%) | 2223 | 0.976 (0.856, 1.112) |
0.71234 | 0.87995 |
| A/C | 399 (28%) | 488 (28%) | 887 | ||||||||
| C/C | 43 (3%) | 47 (3%) | 90 | ||||||||
| 35 | SEZ6L_MG_426 | rs137205 | 22 | 99.4% | A/A | 120 (8%) | 140 (8%) | 260 | 0.982 (0.881, 1.094) |
0.73799 | 0.88413 |
| A/G | 593 (41%) | 785 (44%) | 1378 | ||||||||
| G/G | 729 (51%) | 870 (48%) | 1599 | ||||||||
| 36 | SEZ6L_MG_427 | rs137209 | 22 | 99.5% | A/A | 154 (11%) | 181 (10%) | 335 | 0.984 (0.886, 1.092) |
0.75783 | 0.88413 |
| A/G | 633 (44%) | 833 (46%) | 1466 | ||||||||
| G/G | 656 (45%) | 783 (44%) | 1439 | ||||||||
| 37 | 5Q21_1_MG_435 | rs436495 | 5 | 98.7% | A/A | 77 (5%) | 103 (6%) | 180 | 0.987 (0.883, 1.105) |
0.82607 | 0.91878 |
| A/G | 522 (36%) | 618 (35%) | 1140 | ||||||||
| G/G | 835 (58%) | 1060 (60%) | 1895 | ||||||||
| 38 | 2Q36_3_MG_433 | rs2972147 | 2 | 98.5% | C/C | 571 (40%) | 726 (41%) | 1297 | 0.989 (0.896, 1.093) |
0.83128 | 0.91878 |
| C/T | 668 (47%) | 809 (46%) | 1477 | ||||||||
| T/T | 192 (13%) | 241 (14%) | 433 | ||||||||
| 39 | 2Q36_3_MG_461 | rs2943634 | 2 | 97.4% | A/A | 179 (13%) | 219 (13%) | 398 | 0.992 (0.896, 1.098) |
0.87000 | 0.92819 |
| A/C | 637 (45%) | 793 (45%) | 1430 | ||||||||
| C/C | 603 (42%) | 739 (42%) | 1342 | ||||||||
| 40 | MIA3_MG_454 | rs3008621 | 1 | 98.6% | A/A | 34 (2%) | 43 (2%) | 77 | 0.991 (0.870, 1.130) |
0.89799 | 0.92819 |
| A/G | 367 (26%) | 429 (24%) | 796 | ||||||||
| G/G | 1034 (72%) | 1302 (73%) | 2336 | ||||||||
| 41 | 2Q36_3_MG_447 | rs7597168 | 2 | 99.4% | C/C | 811 (56%) | 1013 (56%) | 1824 | 0.994 (0.887, 1.115) |
0.92443 | 0.92819 |
| C/T | 535 (37%) | 677 (38%) | 1212 | ||||||||
| T/T | 95 (7%) | 104 (6%) | 199 | ||||||||
| 42 | SEZ6L_MG_444 | rs688034 | 22 | 99.5% | C/C | 775 (54%) | 918 (51%) | 1693 | 1.005 (0.899, 1.124) |
0.92819 | 0.92819 |
| C/T | 564 (39%) | 749 (42%) | 1313 | ||||||||
| T/T | 105 (7%) | 128 (7%) | 233 |
Updated on 2008-12-08
