Logistic regression for CHD history at the end of follow-up (healthy subjects at baseline who survived)

Rank SNP name in MORGAM RS-code Chromosome Success Genotype Cases Non-cases Total OR (95% CI) nominal p-value tail-area FDR
1 9P21_3_MG_425 rs1333049 9 99.6% C/C 156 (23%) 283 (17%) 439 1.237
(1.085, 1.410)		 0.00151 0.06144
C/G 329 (49%) 825 (49%) 1154
G/G 189 (28%) 569 (34%) 758
2 9P21_3_MG_420 rs10738610 9 99.1% A/A 186 (28%) 551 (33%) 737 0.819
(0.718, 0.934)		 0.00293 0.06144
A/C 326 (49%) 825 (49%) 1151
C/C 159 (24%) 292 (18%) 451
3 MIA3_MG_454 rs3008621 1 98.5% A/A 12 (2%) 42 (3%) 54 0.845
(0.698, 1.023)		 0.08351 0.90977
A/G 141 (21%) 407 (25%) 548
G/G 518 (77%) 1205 (73%) 1723
4 SEZ6L_MG_426 rs137205 22 99.5% A/A 50 (7%) 135 (8%) 185 0.894
(0.773, 1.035)		 0.13260 0.90977
A/G 278 (41%) 731 (44%) 1009
G/G 346 (51%) 809 (48%) 1155
5 9P21_3_MG_437 rs496892 9 98.9% C/C 191 (29%) 422 (25%) 613 1.095
(0.960, 1.249)		 0.17740 0.90977
C/T 333 (50%) 860 (52%) 1193
T/T 145 (22%) 383 (23%) 528
6 SMAD3_MG_431 rs1866317 15 99.6% C/C 15 (2%) 24 (1%) 39 1.118
(0.924, 1.352)		 0.25159 0.90977
C/G 153 (23%) 383 (23%) 536
G/G 506 (75%) 1269 (76%) 1775
7 MTHFD1L_MG_423 rs12525353 6 99.5% A/A 0 (0%) 2 (0%) 2 0.759
(0.468, 1.232)		 0.26487 0.90977
A/C 23 (3%) 67 (4%) 90
C/C 650 (97%) 1606 (96%) 2256
8 5Q21_1_MG_441 rs565928 5 99.5% C/C 442 (66%) 1061 (63%) 1503 1.086
(0.927, 1.273)		 0.30562 0.90977
C/T 205 (30%) 525 (31%) 730
T/T 27 (4%) 89 (5%) 116
9 5Q21_1_MG_455 rs383830 5 99.1% A/A 26 (4%) 88 (5%) 114 0.920
(0.785, 1.079)		 0.30572 0.90977
A/T 204 (30%) 519 (31%) 723
T/T 444 (66%) 1057 (64%) 1501
10 19Q12_MG_422 rs11670734 19 99.6% C/C 57 (8%) 142 (8%) 199 0.934
(0.808, 1.078)		 0.34962 0.90977
C/G 266 (39%) 682 (41%) 948
G/G 351 (52%) 852 (51%) 1203
11 5Q21_1_MG_435 rs436495 5 98.8% A/A 30 (4%) 100 (6%) 130 0.929
(0.796, 1.085)		 0.35331 0.90977
A/G 225 (34%) 575 (35%) 800
G/G 414 (62%) 988 (59%) 1402
12 MIA3_MG_430 rs17465637 1 99.2% A/A 42 (6%) 122 (7%) 164 0.932
(0.804, 1.081)		 0.35431 0.90977
A/C 248 (37%) 629 (38%) 877
C/C 381 (57%) 920 (55%) 1301
13 SEZ6L_MG_444 rs688034 22 99.5% C/C 355 (53%) 861 (51%) 1216 1.070
(0.924, 1.238)		 0.36924 0.90977
C/T 269 (40%) 691 (41%) 960
T/T 50 (7%) 123 (7%) 173
14 5Q21_1_MG_436 rs449650 5 99.2% G/G 442 (66%) 1061 (64%) 1503 1.075
(0.918, 1.259)		 0.37128 0.90977
G/T 204 (30%) 516 (31%) 720
T/T 27 (4%) 90 (5%) 117
15 CELSR2_MG_434 rs413380 1 99.6% C/C 622 (92%) 1522 (91%) 2144 1.147
(0.840, 1.567)		 0.38798 0.90977
C/T 49 (7%) 147 (9%) 196
T/T 3 (0%) 7 (0%) 10
16 2Q36_3_MG_461 rs2943634 2 96.7% A/A 82 (13%) 208 (13%) 290 0.943
(0.823, 1.081)		 0.40186 0.90977
A/C 276 (43%) 741 (45%) 1017
C/C 286 (44%) 689 (42%) 975
17 SEZ6L_MG_442 rs6005015 22 99.6% C/C 61 (9%) 155 (9%) 216 0.943
(0.819, 1.085)		 0.41078 0.90977
C/T 285 (42%) 721 (43%) 1006
T/T 328 (49%) 800 (48%) 1128
18 9P21_3_MG_459 rs7865618 9 98.8% A/A 225 (33%) 553 (33%) 778 1.055
(0.924, 1.205)		 0.42790 0.90977
A/G 343 (51%) 804 (48%) 1147
G/G 104 (15%) 303 (18%) 407
19 PSRC1_MG_460 rs599839 1 99.2% A/A 399 (60%) 968 (58%) 1367 1.062
(0.913, 1.235)		 0.43714 0.90977
A/G 230 (34%) 599 (36%) 829
G/G 38 (6%) 106 (6%) 144
20 9P21_3_MG_451 rs1537378 9 98.1% A/A 78 (12%) 246 (15%) 324 0.948
(0.828, 1.086)		 0.44219 0.90977
A/G 342 (51%) 777 (47%) 1119
G/G 250 (37%) 623 (38%) 873
21 MTHFD1L_MG_445 rs6922269 6 99.4% A/A 36 (5%) 88 (5%) 124 1.060
(0.910, 1.235)		 0.45488 0.90977
A/G 255 (38%) 593 (35%) 848
G/G 382 (57%) 991 (59%) 1373
22 FMN2_MG_450 rs1456648 1 98.6% G/G 13 (2%) 43 (3%) 56 0.944
(0.787, 1.133)		 0.53778 0.97530
G/T 168 (25%) 435 (26%) 603
T/T 491 (73%) 1178 (71%) 1669
23 SEZ6L_MG_427 rs137209 22 99.6% A/A 65 (10%) 173 (10%) 238 0.958
(0.832, 1.102)		 0.54628 0.97530
A/G 317 (47%) 777 (46%) 1094
G/G 292 (43%) 727 (43%) 1019
24 MTHFD1L_MG_449 rs12214306 6 99.2% C/C 0 (0%) 1 (0%) 1 0.899
(0.593, 1.362)		 0.61482 0.97530
C/T 33 (5%) 86 (5%) 119
T/T 641 (95%) 1580 (95%) 2221
25 1Q31_2_MG_453 rs1936982 1 99.0% C/C 91 (14%) 220 (13%) 311 1.033
(0.906, 1.179)		 0.62569 0.97530
C/T 297 (44%) 718 (43%) 1015
T/T 284 (42%) 727 (44%) 1011
26 SMAD3_MG_452 rs17228212 15 99.1% C/C 36 (5%) 92 (6%) 128 0.966
(0.827, 1.127)		 0.65840 0.97530
C/T 254 (38%) 610 (37%) 864
T/T 383 (57%) 964 (58%) 1347
27 9P21_3_MG_421 rs10757283 9 99.3% C/C 179 (27%) 491 (29%) 670 0.975
(0.855, 1.113)		 0.70792 0.97530
C/T 364 (54%) 833 (50%) 1197
T/T 129 (19%) 348 (21%) 477
28 10Q11_21_MG_439 rs501120 10 97.0% C/C 18 (3%) 41 (3%) 59 1.035
(0.865, 1.238)		 0.70843 0.97530
C/T 166 (25%) 406 (25%) 572
T/T 478 (72%) 1181 (73%) 1659
29 10Q11_21_MG_432 rs2146807 10 99.4% C/C 10 (1%) 14 (1%) 24 1.038
(0.835, 1.289)		 0.73829 0.97530
C/T 118 (18%) 282 (17%) 400
T/T 546 (81%) 1377 (82%) 1923
30 10Q11_21_MG_458 rs622472 10 98.3% A/A 474 (71%) 1150 (70%) 1624 1.023
(0.858, 1.220)		 0.79766 0.97530
A/C 175 (26%) 459 (28%) 634
C/C 19 (3%) 43 (3%) 62
31 SMAD3_MG_424 rs12913547 15 99.6% C/C 48 (7%) 122 (7%) 170 1.019
(0.881, 1.179)		 0.79851 0.97530
C/T 264 (39%) 646 (39%) 910
T/T 362 (54%) 909 (54%) 1271
32 2Q36_3_MG_433 rs2972147 2 98.6% C/C 279 (42%) 680 (41%) 959 1.016
(0.890, 1.160)		 0.81319 0.97530
C/T 295 (44%) 748 (45%) 1043
T/T 95 (14%) 229 (14%) 324
33 SEZ6L_MG_457 rs6005016 22 98.9% A/A 1 (0%) 3 (0%) 4 0.961
(0.685, 1.349)		 0.81942 0.97530
A/G 50 (7%) 119 (7%) 169
G/G 621 (92%) 1541 (93%) 2162
34 12Q12_MG_448 rs7970834 12 99.5% G/G 198 (29%) 530 (32%) 728 0.986
(0.863, 1.126)		 0.83208 0.97530
G/T 357 (53%) 839 (50%) 1196
T/T 117 (17%) 307 (18%) 424
35 2Q36_3_MG_447 rs7597168 2 99.4% C/C 374 (56%) 947 (57%) 1321 0.987
(0.848, 1.148)		 0.86217 0.97530
C/T 265 (39%) 627 (37%) 892
T/T 34 (5%) 100 (6%) 134
36 10Q11_21_MG_456 rs513391 10 99.1% A/A 478 (71%) 1165 (70%) 1643 1.013
(0.849, 1.208)		 0.88547 0.97530
A/C 178 (26%) 458 (28%) 636
C/C 18 (3%) 42 (3%) 60
37 10Q11_21_MG_428 rs1746048 10 99.5% C/C 478 (71%) 1176 (70%) 1654 1.011
(0.848, 1.207)		 0.90108 0.97530
C/T 178 (26%) 458 (27%) 636
T/T 17 (3%) 42 (3%) 59
38 10Q11_21_MG_429 rs1746049 10 99.5% C/C 513 (76%) 1271 (76%) 1784 0.990
(0.817, 1.200)		 0.92185 0.97530
C/T 146 (22%) 379 (23%) 525
T/T 14 (2%) 26 (2%) 40
39 19Q12_MG_446 rs7250581 19 98.2% A/A 16 (2%) 43 (3%) 59 0.993
(0.829, 1.190)		 0.94318 0.97530
A/G 164 (24%) 390 (24%) 554
G/G 490 (73%) 1215 (74%) 1705
40 10Q11_21_MG_443 rs687175 10 99.4% C/C 18 (3%) 42 (3%) 60 0.994
(0.834, 1.185)		 0.94612 0.97530
C/T 178 (26%) 460 (27%) 638
T/T 476 (71%) 1173 (70%) 1649
41 CELSR2_MG_438 rs4970834 1 99.4% C/C 419 (62%) 1054 (63%) 1473 0.996
(0.847, 1.170)		 0.95705 0.97530
C/T 230 (34%) 550 (33%) 780
T/T 23 (3%) 70 (4%) 93
42 10Q11_21_MG_440 rs559580 10 99.3% C/C 18 (3%) 42 (3%) 60 1.003
(0.841, 1.196)		 0.97530 0.97530
C/T 178 (26%) 454 (27%) 632
T/T 478 (71%) 1173 (70%) 1651

adjusted for: cohort mortage sex

Updated on 2008-12-08