Linear regression for HDL cholesterol, test for additive allele effects, subcohort without individuals on cholesterol treatment

Rank SNP name in MORGAM RS-code Chromosome Success Genotype N Mean coef (95% CI) nominal p-value tail-area FDR
1 2Q36_3_MG_433 rs2972147 2 98.6% C/C 721 1.212 -0.036
(-0.058, -0.014)		 0.00155 0.06507
C/T 828 1.271
T/T 249 1.282
2 2Q36_3_MG_461 rs2943634 2 97.7% A/A 228 1.286 0.033
(0.010, 0.055)		 0.00445 0.09343
A/C 809 1.263
C/C 745 1.219
3 MTHFD1L_MG_423 rs12525353 6 99.5% A/A 2 1.500 0.083
(0.008, 0.159)		 0.03072 0.43004
A/C 68 1.323
C/C 1745 1.245
4 2Q36_3_MG_447 rs7597168 2 99.5% C/C 1015 1.230 -0.023
(-0.049, 0.002)		 0.06896 0.68586
C/T 697 1.271
T/T 103 1.257
5 19Q12_MG_446 rs7250581 19 98.0% A/A 44 1.176 -0.027
(-0.058, 0.003)		 0.08165 0.68586
A/G 419 1.232
G/G 1325 1.253
6 SEZ6L_MG_427 rs137209 22 99.7% A/A 191 1.200 -0.018
(-0.042, 0.005)		 0.12016 0.71442
A/G 838 1.249
G/G 789 1.257
7 SEZ6L_MG_426 rs137205 22 99.6% A/A 147 1.206 -0.018
(-0.042, 0.006)		 0.13278 0.71442
A/G 787 1.246
G/G 882 1.256
8 SMAD3_MG_424 rs12913547 15 99.7% C/C 127 1.260 0.018
(-0.007, 0.042)		 0.15523 0.71442
C/T 706 1.249
T/T 985 1.245
9 PSRC1_MG_460 rs599839 1 99.5% A/A 1037 1.244 -0.017
(-0.042, 0.008)		 0.17895 0.71442
A/G 658 1.247
G/G 119 1.287
10 SEZ6L_MG_442 rs6005015 22 99.6% C/C 164 1.226 -0.015
(-0.038, 0.009)		 0.22486 0.71442
C/T 795 1.242
T/T 858 1.257
11 19Q12_MG_422 rs11670734 19 99.6% C/C 138 1.209 -0.012
(-0.036, 0.012)		 0.32877 0.71442
C/G 749 1.250
G/G 930 1.251
12 10Q11_21_MG_456 rs513391 10 99.2% A/A 1275 1.253 0.014
(-0.015, 0.044)		 0.33832 0.71442
A/C 489 1.236
C/C 45 1.245
13 9P21_3_MG_421 rs10757283 9 99.6% C/C 526 1.237 -0.010
(-0.032, 0.011)		 0.34925 0.71442
C/T 915 1.245
T/T 375 1.268
14 10Q11_21_MG_432 rs2146807 10 99.4% C/C 14 1.345 -0.018
(-0.056, 0.020)		 0.36151 0.71442
C/T 289 1.216
T/T 1510 1.253
15 MIA3_MG_430 rs17465637 1 99.3% A/A 139 1.255 0.011
(-0.013, 0.035)		 0.36231 0.71442
A/C 664 1.255
C/C 1008 1.242
16 SEZ6L_MG_444 rs688034 22 99.6% C/C 937 1.249 0.011
(-0.013, 0.036)		 0.37187 0.71442
C/T 752 1.254
T/T 127 1.202
17 SMAD3_MG_452 rs17228212 15 99.2% C/C 97 1.267 -0.012
(-0.038, 0.014)		 0.37777 0.71442
C/T 663 1.241
T/T 1049 1.251
18 12Q12_MG_448 rs7970834 12 99.7% G/G 555 1.267 0.010
(-0.012, 0.032)		 0.38820 0.71442
G/T 923 1.235
T/T 340 1.251
19 MTHFD1L_MG_445 rs6922269 6 99.4% A/A 96 1.215 -0.011
(-0.037, 0.015)		 0.39446 0.71442
A/G 636 1.244
G/G 1081 1.253
20 CELSR2_MG_438 rs4970834 1 99.6% C/C 1130 1.248 -0.011
(-0.038, 0.015)		 0.39587 0.71442
C/T 607 1.239
T/T 79 1.317
21 FMN2_MG_450 rs1456648 1 98.6% G/G 42 1.290 0.013
(-0.017, 0.043)		 0.40515 0.71442
G/T 469 1.257
T/T 1288 1.244
22 10Q11_21_MG_458 rs622472 10 98.5% A/A 1261 1.252 0.012
(-0.017, 0.042)		 0.42432 0.71442
A/C 489 1.238
C/C 46 1.246
23 CELSR2_MG_434 rs413380 1 99.6% C/C 1652 1.246 -0.020
(-0.068, 0.029)		 0.42475 0.71442
C/T 155 1.271
T/T 10 1.155
24 MIA3_MG_454 rs3008621 1 98.7% A/A 47 1.221 0.012
(-0.018, 0.042)		 0.43412 0.71442
A/G 436 1.259
G/G 1317 1.244
25 10Q11_21_MG_443 rs687175 10 99.6% C/C 44 1.260 -0.012
(-0.041, 0.018)		 0.43848 0.71442
C/T 491 1.236
T/T 1281 1.252
26 10Q11_21_MG_428 rs1746048 10 99.6% C/C 1284 1.252 0.012
(-0.018, 0.041)		 0.44226 0.71442
C/T 489 1.235
T/T 44 1.260
27 10Q11_21_MG_440 rs559580 10 99.1% C/C 44 1.260 -0.011
(-0.040, 0.019)		 0.47801 0.72096
C/T 486 1.238
T/T 1278 1.253
28 10Q11_21_MG_439 rs501120 10 96.7% C/C 43 1.253 -0.011
(-0.041, 0.020)		 0.48064 0.72096
C/T 431 1.242
T/T 1289 1.251
29 SEZ6L_MG_457 rs6005016 22 99.0% A/A 4 1.198 0.017
(-0.041, 0.075)		 0.55981 0.81076
A/G 121 1.252
G/G 1680 1.248
30 9P21_3_MG_459 rs7865618 9 98.9% A/A 591 1.234 -0.005
(-0.027, 0.016)		 0.62332 0.82240
A/G 881 1.260
G/G 332 1.247
31 SMAD3_MG_431 rs1866317 15 99.6% C/C 29 1.228 -0.008
(-0.040, 0.024)		 0.62620 0.82240
C/G 425 1.231
G/G 1363 1.253
32 1Q31_2_MG_453 rs1936982 1 99.1% C/C 227 1.277 0.006
(-0.017, 0.028)		 0.62659 0.82240
C/T 784 1.244
T/T 796 1.245
33 9P21_3_MG_425 rs1333049 9 99.7% C/C 302 1.216 0.002
(-0.020, 0.024)		 0.83694 0.96113
C/G 897 1.266
G/G 619 1.237
34 9P21_3_MG_437 rs496892 9 99.2% C/C 460 1.228 0.002
(-0.020, 0.024)		 0.84893 0.96113
C/T 933 1.261
T/T 416 1.236
35 5Q21_1_MG_436 rs449650 5 99.1% G/G 1126 1.251 0.002
(-0.023, 0.028)		 0.85458 0.96113
G/T 583 1.247
T/T 98 1.233
36 9P21_3_MG_420 rs10738610 9 99.2% A/A 603 1.233 -0.002
(-0.024, 0.020)		 0.86127 0.96113
A/C 895 1.271
C/C 312 1.214
37 10Q11_21_MG_429 rs1746049 10 99.6% C/C 1375 1.246 -0.002
(-0.035, 0.030)		 0.89087 0.96113
C/T 415 1.250
T/T 27 1.264
38 5Q21_1_MG_435 rs436495 5 98.9% A/A 111 1.237 0.001
(-0.024, 0.026)		 0.92246 0.96113
A/G 639 1.250
G/G 1054 1.246
39 5Q21_1_MG_441 rs565928 5 99.6% C/C 1129 1.249 0.001
(-0.025, 0.027)		 0.94443 0.96113
C/T 590 1.248
T/T 97 1.234
40 MTHFD1L_MG_449 rs12214306 6 99.2% C/C 1 1.330 0.002
(-0.070, 0.074)		 0.95508 0.96113
C/T 82 1.251
T/T 1727 1.248
41 5Q21_1_MG_455 rs383830 5 99.1% A/A 96 1.235 -0.001
(-0.027, 0.025)		 0.95689 0.96113
A/T 586 1.248
T/T 1126 1.250
42 9P21_3_MG_451 rs1537378 9 98.3% A/A 267 1.231 -0.001
(-0.023, 0.022)		 0.96113 0.96113
A/G 878 1.258
G/G 648 1.241

adjusted for: cohort age1 sex

Updated on 2008-12-08