Cox regression for DEATH endpoint, test for multiplicative allele effects, men and women model for MTHFD1L_MG

response: (death=='1') 
covariates: dsmoker 
SNP: MTHFD1L_MG_449 
Call:
coxph(formula = y[notmissing] ~ allele[notmissing] + wz[notmissing, 
    selectedcovariates] + wruaco[notmissing] + strata(wsex[notmissing]) + 
    cluster(wdata$id[notmissing]), weights = weight[notmissing], 
    robust = TRUE)

  n= 3507 
                                      coef exp(coef) se(coef) robust se      z
allele[notmissing]                 -0.1652    0.8477   0.1260     0.165 -1.000
wz[notmissing, selectedcovariates]  0.5881    1.8005   0.0667     0.091  6.460
wruaco[notmissing]FIN-EAS_03        0.0576    1.0593   0.1242     0.162  0.356
wruaco[notmissing]FIN-EAS_24       -0.1927    0.8247   0.1015     0.135 -1.427
wruaco[notmissing]FIN-WES_03        0.0430    1.0439   0.1198     0.155  0.277
wruaco[notmissing]FIN-WES_24       -0.2213    0.8015   0.1067     0.148 -1.498
wruaco[notmissing]FRA-LIL_21       -2.4551    0.0859   0.5828     0.614 -3.996
wruaco[notmissing]FRA-STR_21       -0.2554    0.7746   0.1968     0.254 -1.006
wruaco[notmissing]FRA-TOU_21       -0.5220    0.5933   0.2313     0.279 -1.874
wruaco[notmissing]SWE-NSW_02       -0.2433    0.7841   0.1672     0.217 -1.121
wruaco[notmissing]SWE-NSW_03       -0.6169    0.5396   0.1804     0.218 -2.825
wruaco[notmissing]UNK-BEL_21       -0.3061    0.7363   0.1747     0.213 -1.435
                                         p
allele[notmissing]                 3.2e-01
wz[notmissing, selectedcovariates] 1.0e-10
wruaco[notmissing]FIN-EAS_03       7.2e-01
wruaco[notmissing]FIN-EAS_24       1.5e-01
wruaco[notmissing]FIN-WES_03       7.8e-01
wruaco[notmissing]FIN-WES_24       1.3e-01
wruaco[notmissing]FRA-LIL_21       6.4e-05
wruaco[notmissing]FRA-STR_21       3.1e-01
wruaco[notmissing]FRA-TOU_21       6.1e-02
wruaco[notmissing]SWE-NSW_02       2.6e-01
wruaco[notmissing]SWE-NSW_03       4.7e-03
wruaco[notmissing]UNK-BEL_21       1.5e-01

                                   exp(coef) exp(-coef) lower .95 upper .95
allele[notmissing]                    0.8477      1.180    0.6132     1.172
wz[notmissing, selectedcovariates]    1.8005      0.555    1.5063     2.152
wruaco[notmissing]FIN-EAS_03          1.0593      0.944    0.7714     1.454
wruaco[notmissing]FIN-EAS_24          0.8247      1.213    0.6329     1.075
wruaco[notmissing]FIN-WES_03          1.0439      0.958    0.7704     1.415
wruaco[notmissing]FIN-WES_24          0.8015      1.248    0.6000     1.071
wruaco[notmissing]FRA-LIL_21          0.0859     11.647    0.0258     0.286
wruaco[notmissing]FRA-STR_21          0.7746      1.291    0.4709     1.274
wruaco[notmissing]FRA-TOU_21          0.5933      1.685    0.3437     1.024
wruaco[notmissing]SWE-NSW_02          0.7841      1.275    0.5124     1.200
wruaco[notmissing]SWE-NSW_03          0.5396      1.853    0.3517     0.828
wruaco[notmissing]UNK-BEL_21          0.7363      1.358    0.4847     1.118

Rsquare= 0.06   (max possible= 0.998 )
Likelihood ratio test= 216  on 12 df,   p=0
Wald test            = 116  on 12 df,   p=0
Score (logrank) test = 196  on 12 df,   p=0,   Robust = 121  p=0

  (Note: the likelihood ratio and score tests assume independence of
     observations within a cluster, the Wald and robust score tests do not).
Updated on 2008-06-04