response: (stroke2=='1') 
covariates: dsmoker 
SNP: MTHFD1L_MG_445 
Call:
coxph(formula = y[notmissing] ~ allele[notmissing] + wz[notmissing, 
    selectedcovariates] + wruaco[notmissing] + strata(wsex[notmissing]) + 
    cluster(wdata$id[notmissing]), weights = weight[notmissing], 
    robust = TRUE)

  n= 2158 
                                       coef exp(coef) se(coef) robust se
allele[notmissing]                   0.2397  1.27e+00    0.172     0.179
wz[notmissing, selectedcovariates]   0.1733  1.19e+00    0.260     0.262
wruaco[notmissing]FIN-EAS_03        -1.3902  2.49e-01    0.780     0.795
wruaco[notmissing]FIN-EAS_24        -0.6418  5.26e-01    0.432     0.435
wruaco[notmissing]FIN-WES_03        -0.3516  7.04e-01    0.507     0.484
wruaco[notmissing]FIN-WES_24        -0.9034  4.05e-01    0.477     0.539
wruaco[notmissing]FRA-LIL_21       -16.5571  6.45e-08 2533.563     0.377
wruaco[notmissing]FRA-STR_21        -0.4590  6.32e-01    0.807     0.768
wruaco[notmissing]FRA-TOU_21       -16.6575  5.83e-08 2531.631     0.396
wruaco[notmissing]SWE-NSW_02         0.0908  1.10e+00    0.549     0.566
wruaco[notmissing]SWE-NSW_03        -0.2385  7.88e-01    0.526     0.533
wruaco[notmissing]UNK-BEL_21        -0.0805  9.23e-01    0.644     0.619
                                         z     p
allele[notmissing]                   1.341 0.180
wz[notmissing, selectedcovariates]   0.662 0.510
wruaco[notmissing]FIN-EAS_03        -1.749 0.080
wruaco[notmissing]FIN-EAS_24        -1.476 0.140
wruaco[notmissing]FIN-WES_03        -0.727 0.470
wruaco[notmissing]FIN-WES_24        -1.675 0.094
wruaco[notmissing]FRA-LIL_21       -43.861 0.000
wruaco[notmissing]FRA-STR_21        -0.597 0.550
wruaco[notmissing]FRA-TOU_21       -42.031 0.000
wruaco[notmissing]SWE-NSW_02         0.160 0.870
wruaco[notmissing]SWE-NSW_03        -0.448 0.650
wruaco[notmissing]UNK-BEL_21        -0.130 0.900

                                   exp(coef) exp(-coef) lower .95 upper .95
allele[notmissing]                  1.27e+00   7.87e-01  8.95e-01  1.80e+00
wz[notmissing, selectedcovariates]  1.19e+00   8.41e-01  7.12e-01  1.99e+00
wruaco[notmissing]FIN-EAS_03        2.49e-01   4.02e+00  5.24e-02  1.18e+00
wruaco[notmissing]FIN-EAS_24        5.26e-01   1.90e+00  2.24e-01  1.23e+00
wruaco[notmissing]FIN-WES_03        7.04e-01   1.42e+00  2.73e-01  1.82e+00
wruaco[notmissing]FIN-WES_24        4.05e-01   2.47e+00  1.41e-01  1.17e+00
wruaco[notmissing]FRA-LIL_21        6.45e-08   1.55e+07  3.08e-08  1.35e-07
wruaco[notmissing]FRA-STR_21        6.32e-01   1.58e+00  1.40e-01  2.85e+00
wruaco[notmissing]FRA-TOU_21        5.83e-08   1.71e+07  2.68e-08  1.27e-07
wruaco[notmissing]SWE-NSW_02        1.10e+00   9.13e-01  3.61e-01  3.32e+00
wruaco[notmissing]SWE-NSW_03        7.88e-01   1.27e+00  2.77e-01  2.24e+00
wruaco[notmissing]UNK-BEL_21        9.23e-01   1.08e+00  2.74e-01  3.11e+00

Rsquare= 0.01   (max possible= 0.467 )
Likelihood ratio test= 22.2  on 12 df,   p=0.035
Wald test            = 3978  on 12 df,   p=0
Score (logrank) test = 18.1  on 12 df,   p=0.114,   Robust = 30.2  p=0.00264

  (Note: the likelihood ratio and score tests assume independence of
     observations within a cluster, the Wald and robust score tests do not).

Updated on 2008-06-04