Cox regression for STROKE4 endpoint, test for multiplicative allele effects, men and women model for CELSR2_MG

response: (stroke4 %in% c('1','2','3','4','5','6')) 
covariates: dsmoker 
SNP: CELSR2_MG_438 
Call:
coxph(formula = y[notmissing] ~ allele[notmissing] + wz[notmissing, 
    selectedcovariates] + wruaco[notmissing] + strata(wsex[notmissing]) + 
    cluster(wdata$id[notmissing]), weights = weight[notmissing], 
    robust = TRUE)

  n= 2506 
                                      coef exp(coef) se(coef) robust se      z
allele[notmissing]                  0.0163     1.016   0.0855    0.0958  0.170
wz[notmissing, selectedcovariates]  0.2925     1.340   0.1202    0.1324  2.209
wruaco[notmissing]FIN-EAS_03        0.2129     1.237   0.2106    0.2261  0.942
wruaco[notmissing]FIN-EAS_24       -0.1264     0.881   0.1801    0.2048 -0.617
wruaco[notmissing]FIN-WES_03       -0.0980     0.907   0.2198    0.2375 -0.413
wruaco[notmissing]FIN-WES_24       -0.2155     0.806   0.1926    0.2211 -0.974
wruaco[notmissing]FRA-LIL_21       -0.9948     0.370   0.4698    0.4994 -1.992
wruaco[notmissing]FRA-STR_21       -1.0406     0.353   0.4381    0.4618 -2.253
wruaco[notmissing]FRA-TOU_21       -1.2594     0.284   0.5252    0.5568 -2.262
wruaco[notmissing]SWE-NSW_02       -0.0465     0.955   0.2755    0.3098 -0.150
wruaco[notmissing]SWE-NSW_03        0.1039     1.109   0.2507    0.2763  0.376
wruaco[notmissing]UNK-BEL_21       -0.8205     0.440   0.3561    0.3738 -2.195
                                       p
allele[notmissing]                 0.870
wz[notmissing, selectedcovariates] 0.027
wruaco[notmissing]FIN-EAS_03       0.350
wruaco[notmissing]FIN-EAS_24       0.540
wruaco[notmissing]FIN-WES_03       0.680
wruaco[notmissing]FIN-WES_24       0.330
wruaco[notmissing]FRA-LIL_21       0.046
wruaco[notmissing]FRA-STR_21       0.024
wruaco[notmissing]FRA-TOU_21       0.024
wruaco[notmissing]SWE-NSW_02       0.880
wruaco[notmissing]SWE-NSW_03       0.710
wruaco[notmissing]UNK-BEL_21       0.028

                                   exp(coef) exp(-coef) lower .95 upper .95
allele[notmissing]                     1.016      0.984    0.8424     1.226
wz[notmissing, selectedcovariates]     1.340      0.746    1.0336     1.737
wruaco[notmissing]FIN-EAS_03           1.237      0.808    0.7944     1.927
wruaco[notmissing]FIN-EAS_24           0.881      1.135    0.5899     1.316
wruaco[notmissing]FIN-WES_03           0.907      1.103    0.5692     1.444
wruaco[notmissing]FIN-WES_24           0.806      1.240    0.5226     1.244
wruaco[notmissing]FRA-LIL_21           0.370      2.704    0.1390     0.984
wruaco[notmissing]FRA-STR_21           0.353      2.831    0.1429     0.873
wruaco[notmissing]FRA-TOU_21           0.284      3.523    0.0953     0.845
wruaco[notmissing]SWE-NSW_02           0.955      1.048    0.5201     1.752
wruaco[notmissing]SWE-NSW_03           1.109      0.901    0.6455     1.907
wruaco[notmissing]UNK-BEL_21           0.440      2.272    0.2116     0.916

Rsquare= 0.016   (max possible= 0.93 )
Likelihood ratio test= 39.7  on 12 df,   p=8.15e-05
Wald test            = 33.1  on 12 df,   p=0.000934
Score (logrank) test = 37.4  on 12 df,   p=0.000190,   Robust = 35.4  p=0.000407

  (Note: the likelihood ratio and score tests assume independence of
     observations within a cluster, the Wald and robust score tests do not).
Updated on 2008-06-04