Cox regression for non-fatal CHD1 endpoint, test for multiplicative allele effects, men and women

rank SNP RS-code Chromosome Success Genotype Cases Non-cases Total HR (95% CI) nominal p-value tail-area FDR
1 9P21_3_MG_425 rs1333049 9 99.6% C/C 172 (23%) 321 (17%) 493 1.232
(1.080, 1.406)		 0.00189 0.07939
C/G 368 (49%) 950 (49%) 1318
G/G 213 (28%) 662 (34%) 875
2 9P21_3_MG_420 rs10738610 9 99.1% A/A 210 (28%) 644 (33%) 854 0.826
(0.725, 0.942)		 0.00444 0.09328
A/C 366 (49%) 950 (49%) 1316
C/C 174 (23%) 330 (17%) 504
3 MIA3_MG_454 rs3008621 1 98.7% A/A 12 (2%) 52 (3%) 64 0.812
(0.668, 0.987)		 0.03650 0.51107
A/G 156 (21%) 469 (25%) 625
G/G 582 (78%) 1392 (73%) 1974
4 MTHFD1L_MG_423 rs12525353 6 99.4% A/A 0 (0%) 2 (0%) 2 0.712
(0.430, 1.180)		 0.18742 0.99327
A/C 25 (3%) 75 (4%) 100
C/C 727 (97%) 1853 (96%) 2580
5 9P21_3_MG_437 rs496892 9 98.8% C/C 210 (28%) 481 (25%) 691 1.092
(0.951, 1.252)		 0.21146 0.99327
C/T 370 (50%) 1000 (52%) 1370
T/T 165 (22%) 439 (23%) 604
6 5Q21_1_MG_435 rs436495 5 98.8% A/A 33 (4%) 118 (6%) 151 0.911
(0.778, 1.067)		 0.24638 0.99327
A/G 249 (33%) 671 (35%) 920
G/G 464 (62%) 1130 (59%) 1594
7 SEZ6L_MG_426 rs137205 22 99.5% A/A 53 (7%) 154 (8%) 207 0.921
(0.794, 1.068)		 0.27483 0.99327
A/G 313 (42%) 833 (43%) 1146
G/G 387 (51%) 944 (49%) 1331
8 SMAD3_MG_424 rs12913547 15 99.6% C/C 55 (7%) 136 (7%) 191 1.084
(0.937, 1.255)		 0.27668 0.99327
C/T 298 (40%) 750 (39%) 1048
T/T 400 (53%) 1047 (54%) 1447
9 MIA3_MG_430 rs17465637 1 99.1% A/A 46 (6%) 145 (8%) 191 0.923
(0.795, 1.072)		 0.29570 0.99327
A/C 270 (36%) 716 (37%) 986
C/C 434 (58%) 1064 (55%) 1498
10 CELSR2_MG_438 rs4970834 1 99.4% C/C 465 (62%) 1213 (63%) 1678 0.920
(0.784, 1.079)		 0.30350 0.99327
C/T 260 (35%) 637 (33%) 897
T/T 26 (3%) 80 (4%) 106
11 10Q11_21_MG_429 rs1746049 10 99.5% C/C 567 (75%) 1465 (76%) 2032 0.910
(0.753, 1.100)		 0.33138 0.99327
C/T 168 (22%) 438 (23%) 606
T/T 17 (2%) 29 (2%) 46
12 10Q11_21_MG_432 rs2146807 10 99.3% C/C 10 (1%) 15 (1%) 25 1.116
(0.888, 1.402)		 0.34705 0.99327
C/T 137 (18%) 320 (17%) 457
T/T 606 (80%) 1592 (83%) 2198
13 5Q21_1_MG_441 rs565928 5 99.5% C/C 494 (66%) 1210 (63%) 1704 1.080
(0.919, 1.269)		 0.35238 0.99327
C/T 229 (30%) 617 (32%) 846
T/T 30 (4%) 104 (5%) 134
14 5Q21_1_MG_455 rs383830 5 99.2% A/A 29 (4%) 103 (5%) 132 0.926
(0.787, 1.089)		 0.35362 0.99327
A/T 228 (30%) 611 (32%) 839
T/T 496 (66%) 1209 (63%) 1705
15 5Q21_1_MG_436 rs449650 5 99.1% G/G 494 (66%) 1208 (63%) 1702 1.074
(0.914, 1.262)		 0.38671 0.99327
G/T 228 (30%) 608 (32%) 836
T/T 30 (4%) 105 (5%) 135
16 SEZ6L_MG_444 rs688034 22 99.5% C/C 403 (54%) 1009 (52%) 1412 1.067
(0.919, 1.238)		 0.39292 0.99327
C/T 299 (40%) 787 (41%) 1086
T/T 51 (7%) 135 (7%) 186
17 2Q36_3_MG_461 rs2943634 2 96.8% A/A 90 (13%) 242 (13%) 332 0.943
(0.819, 1.085)		 0.41324 0.99327
A/C 309 (43%) 863 (46%) 1172
C/C 320 (45%) 787 (42%) 1107
18 9P21_3_MG_459 rs7865618 9 99.0% A/A 254 (34%) 629 (33%) 883 1.053
(0.925, 1.199)		 0.43331 0.99327
A/G 379 (50%) 942 (49%) 1321
G/G 118 (16%) 348 (18%) 466
19 10Q11_21_MG_439 rs501120 10 96.9% C/C 21 (3%) 47 (3%) 68 1.064
(0.894, 1.266)		 0.48614 0.99327
C/T 189 (26%) 470 (25%) 659
T/T 530 (72%) 1358 (72%) 1888
20 9P21_3_MG_451 rs1537378 9 98.3% A/A 87 (12%) 278 (15%) 365 0.955
(0.837, 1.091)		 0.50083 0.99327
A/G 381 (51%) 927 (49%) 1308
G/G 281 (38%) 699 (37%) 980
21 MTHFD1L_MG_445 rs6922269 6 99.3% A/A 40 (5%) 104 (5%) 144 1.048
(0.899, 1.222)		 0.55086 0.99327
A/G 284 (38%) 677 (35%) 961
G/G 428 (57%) 1147 (59%) 1575
22 SEZ6L_MG_457 rs6005016 22 99.1% A/A 1 (0%) 4 (0%) 5 1.094
(0.788, 1.518)		 0.59308 0.99327
A/G 58 (8%) 131 (7%) 189
G/G 692 (92%) 1787 (93%) 2479
23 9P21_3_MG_421 rs10757283 9 99.3% C/C 201 (27%) 560 (29%) 761 0.966
(0.849, 1.099)		 0.59901 0.99327
C/T 402 (54%) 969 (50%) 1371
T/T 148 (20%) 399 (21%) 547
24 1Q31_2_MG_453 rs1936982 1 99.1% C/C 105 (14%) 248 (13%) 353 1.033
(0.902, 1.184)		 0.63816 0.99327
C/T 327 (44%) 836 (43%) 1163
T/T 319 (42%) 839 (44%) 1158
25 SEZ6L_MG_442 rs6005015 22 99.5% C/C 70 (9%) 172 (9%) 242 0.968
(0.838, 1.117)		 0.65409 0.99327
C/T 315 (42%) 842 (44%) 1157
T/T 368 (49%) 918 (48%) 1286
26 CELSR2_MG_434 rs413380 1 99.5% C/C 692 (92%) 1752 (91%) 2444 1.054
(0.781, 1.423)		 0.73001 0.99327
C/T 58 (8%) 171 (9%) 229
T/T 3 (0%) 9 (0%) 12
27 FMN2_MG_450 rs1456648 1 98.7% G/G 17 (2%) 46 (2%) 63 1.028
(0.858, 1.232)		 0.76487 0.99327
G/T 191 (25%) 499 (26%) 690
T/T 542 (72%) 1369 (72%) 1911
28 10Q11_21_MG_440 rs559580 10 99.1% C/C 21 (3%) 48 (2%) 69 1.024
(0.862, 1.216)		 0.78561 0.99327
C/T 202 (27%) 525 (27%) 727
T/T 530 (70%) 1349 (70%) 1879
29 12Q12_MG_448 rs7970834 12 99.4% G/G 222 (30%) 607 (31%) 829 1.017
(0.890, 1.163)		 0.80200 0.99327
G/T 395 (53%) 971 (50%) 1366
T/T 133 (18%) 354 (18%) 487
30 SMAD3_MG_452 rs17228212 15 99.2% C/C 41 (5%) 105 (5%) 146 0.982
(0.837, 1.152)		 0.82442 0.99327
C/T 282 (38%) 700 (36%) 982
T/T 429 (57%) 1120 (58%) 1549
31 10Q11_21_MG_428 rs1746048 10 99.5% C/C 530 (70%) 1355 (70%) 1885 0.983
(0.826, 1.169)		 0.84400 0.99327
C/T 202 (27%) 529 (27%) 731
T/T 20 (3%) 48 (2%) 68
32 2Q36_3_MG_433 rs2972147 2 98.6% C/C 314 (42%) 770 (40%) 1084 1.013
(0.884, 1.160)		 0.85362 0.99327
C/T 329 (44%) 878 (46%) 1207
T/T 105 (14%) 264 (14%) 369
33 10Q11_21_MG_443 rs687175 10 99.4% C/C 21 (3%) 48 (2%) 69 1.016
(0.855, 1.207)		 0.85526 0.99327
C/T 202 (27%) 531 (28%) 733
T/T 528 (70%) 1351 (70%) 1879
34 MTHFD1L_MG_449 rs12214306 6 99.3% C/C 0 (0%) 1 (0%) 1 0.963
(0.630, 1.473)		 0.86259 0.99327
C/T 36 (5%) 93 (5%) 129
T/T 717 (95%) 1832 (95%) 2549
35 2Q36_3_MG_447 rs7597168 2 99.3% C/C 424 (56%) 1077 (56%) 1501 0.988
(0.847, 1.151)		 0.87450 0.99327
C/T 291 (39%) 738 (38%) 1029
T/T 36 (5%) 114 (6%) 150
36 SMAD3_MG_431 rs1866317 15 99.5% C/C 15 (2%) 29 (2%) 44 1.012
(0.828, 1.238)		 0.90392 0.99327
C/G 167 (22%) 460 (24%) 627
G/G 571 (76%) 1443 (75%) 2014
37 PSRC1_MG_460 rs599839 1 99.2% A/A 436 (59%) 1116 (58%) 1552 0.993
(0.856, 1.152)		 0.92674 0.99327
A/G 269 (36%) 696 (36%) 965
G/G 40 (5%) 120 (6%) 160
38 19Q12_MG_422 rs11670734 19 99.5% C/C 68 (9%) 153 (8%) 221 0.994
(0.857, 1.153)		 0.93545 0.99327
C/G 301 (40%) 785 (41%) 1086
G/G 384 (51%) 994 (51%) 1378
39 10Q11_21_MG_458 rs622472 10 98.5% A/A 526 (71%) 1331 (70%) 1857 1.006
(0.847, 1.196)		 0.94528 0.99327
A/C 198 (27%) 530 (28%) 728
C/C 22 (3%) 50 (3%) 72
40 10Q11_21_MG_456 rs513391 10 99.2% A/A 530 (70%) 1346 (70%) 1876 0.997
(0.839, 1.184)		 0.97255 0.99327
A/C 202 (27%) 529 (27%) 731
C/C 21 (3%) 49 (3%) 70
41 19Q12_MG_446 rs7250581 19 98.2% A/A 19 (3%) 49 (3%) 68 0.999
(0.834, 1.196)		 0.99016 0.99327
A/G 184 (25%) 446 (23%) 630
G/G 545 (73%) 1406 (74%) 1951
42 SEZ6L_MG_427 rs137209 22 99.6% A/A 72 (10%) 198 (10%) 270 0.999
(0.867, 1.152)		 0.99327 0.99327
A/G 351 (47%) 893 (46%) 1244
G/G 330 (44%) 842 (44%) 1172

stratified by sex, adjusted for: cohort nonhdl hdla bmi bpm dsmoker hisdiab1

Updated on 2008-12-08