Cox regression for non-fatal STROKE4 endpoint, test for multiplicative allele effects, men and women

rank SNP RS-code Chromosome Success Genotype Cases Non-cases Total HR (95% CI) nominal p-value tail-area FDR
1 9P21_3_MG_425 rs1333049 9 99.6% C/C 79 (20%) 336 (17%) 415 1.139
(0.969, 1.338)		 0.11387 0.86264
C/G 195 (48%) 977 (49%) 1172
G/G 130 (32%) 685 (34%) 815
2 19Q12_MG_422 rs11670734 19 99.5% C/C 37 (9%) 153 (8%) 190 1.152
(0.963, 1.379)		 0.12236 0.86264
C/G 162 (40%) 814 (41%) 976
G/G 205 (51%) 1030 (52%) 1235
3 10Q11_21_MG_458 rs622472 10 98.4% A/A 287 (72%) 1382 (70%) 1669 1.184
(0.950, 1.476)		 0.13295 0.86264
A/C 103 (26%) 538 (27%) 641
C/C 9 (2%) 54 (3%) 63
4 9P21_3_MG_420 rs10738610 9 99.1% A/A 127 (32%) 668 (34%) 795 0.886
(0.754, 1.041)		 0.13963 0.86264
A/C 195 (49%) 976 (49%) 1171
C/C 79 (20%) 346 (17%) 425
5 SEZ6L_MG_427 rs137209 22 99.6% A/A 43 (11%) 199 (10%) 242 0.873
(0.727, 1.048)		 0.14576 0.86264
A/G 156 (39%) 924 (46%) 1080
G/G 205 (51%) 875 (44%) 1080
6 10Q11_21_MG_456 rs513391 10 99.1% A/A 289 (72%) 1398 (70%) 1687 1.173
(0.941, 1.463)		 0.15518 0.86264
A/C 103 (26%) 538 (27%) 641
C/C 9 (2%) 53 (3%) 62
7 10Q11_21_MG_440 rs559580 10 99.1% C/C 9 (2%) 52 (3%) 61 0.856
(0.687, 1.067)		 0.16738 0.86264
C/T 104 (26%) 535 (27%) 639
T/T 291 (72%) 1400 (70%) 1691
8 10Q11_21_MG_439 rs501120 10 96.7% C/C 9 (2%) 51 (3%) 60 0.856
(0.680, 1.076)		 0.18224 0.86264
C/T 92 (24%) 480 (25%) 572
T/T 290 (74%) 1410 (73%) 1700
9 10Q11_21_MG_443 rs687175 10 99.5% C/C 9 (2%) 52 (3%) 61 0.862
(0.692, 1.074)		 0.18485 0.86264
C/T 105 (26%) 540 (27%) 645
T/T 290 (72%) 1403 (70%) 1693
10 10Q11_21_MG_428 rs1746048 10 99.5% C/C 290 (72%) 1407 (70%) 1697 1.151
(0.924, 1.435)		 0.20888 0.87731
C/T 105 (26%) 538 (27%) 643
T/T 9 (2%) 51 (3%) 60
11 9P21_3_MG_421 rs10757283 9 99.3% C/C 104 (26%) 580 (29%) 684 0.909
(0.772, 1.069)		 0.24767 0.87765
C/T 203 (50%) 1011 (51%) 1214
T/T 96 (24%) 401 (20%) 497
12 MTHFD1L_MG_423 rs12525353 6 99.4% A/A 0 (0%) 2 (0%) 2 0.698
(0.367, 1.328)		 0.27322 0.87765
A/C 12 (3%) 78 (4%) 90
C/C 391 (97%) 1915 (96%) 2306
13 FMN2_MG_450 rs1456648 1 98.6% G/G 13 (3%) 47 (2%) 60 0.879
(0.697, 1.108)		 0.27359 0.87765
G/T 87 (22%) 512 (26%) 599
T/T 300 (75%) 1419 (72%) 1719
14 SEZ6L_MG_444 rs688034 22 99.5% C/C 228 (57%) 1041 (52%) 1269 1.102
(0.915, 1.327)		 0.30719 0.87765
C/T 150 (37%) 818 (41%) 968
T/T 25 (6%) 137 (7%) 162
15 9P21_3_MG_451 rs1537378 9 98.2% A/A 52 (13%) 294 (15%) 346 0.920
(0.782, 1.084)		 0.31920 0.87765
A/G 198 (49%) 959 (49%) 1157
G/G 151 (38%) 715 (36%) 866
16 10Q11_21_MG_432 rs2146807 10 99.3% C/C 2 (0%) 14 (1%) 16 0.865
(0.634, 1.180)		 0.36087 0.87765
C/T 61 (15%) 328 (16%) 389
T/T 341 (84%) 1650 (83%) 1991
17 MIA3_MG_454 rs3008621 1 98.5% A/A 8 (2%) 51 (3%) 59 0.901
(0.718, 1.130)		 0.36737 0.87765
A/G 94 (24%) 480 (24%) 574
G/G 297 (74%) 1447 (73%) 1744
18 SEZ6L_MG_426 rs137205 22 99.5% A/A 36 (9%) 152 (8%) 188 0.919
(0.763, 1.108)		 0.37614 0.87765
A/G 148 (37%) 862 (43%) 1010
G/G 220 (54%) 982 (49%) 1202
19 12Q12_MG_448 rs7970834 12 99.5% G/G 121 (30%) 622 (31%) 743 0.933
(0.788, 1.104)		 0.41904 0.92508
G/T 201 (50%) 1008 (51%) 1209
T/T 82 (20%) 366 (18%) 448
20 SMAD3_MG_452 rs17228212 15 99.1% C/C 23 (6%) 108 (5%) 131 1.076
(0.885, 1.309)		 0.46298 0.92508
C/T 144 (36%) 722 (36%) 866
T/T 234 (58%) 1160 (58%) 1394
21 5Q21_1_MG_435 rs436495 5 98.8% A/A 27 (7%) 117 (6%) 144 0.937
(0.774, 1.133)		 0.50084 0.92508
A/G 130 (32%) 695 (35%) 825
G/G 243 (61%) 1170 (59%) 1413
22 SMAD3_MG_424 rs12913547 15 99.6% C/C 25 (6%) 140 (7%) 165 1.059
(0.887, 1.264)		 0.52684 0.92508
C/T 171 (42%) 774 (39%) 945
T/T 208 (51%) 1084 (54%) 1292
23 MTHFD1L_MG_449 rs12214306 6 99.2% C/C 1 (0%) 1 (0%) 2 0.840
(0.484, 1.456)		 0.53384 0.92508
C/T 16 (4%) 93 (5%) 109
T/T 384 (96%) 1897 (95%) 2281
24 19Q12_MG_446 rs7250581 19 98.0% A/A 12 (3%) 49 (2%) 61 1.074
(0.858, 1.344)		 0.53418 0.92508
A/G 96 (24%) 462 (23%) 558
G/G 290 (73%) 1455 (74%) 1745
25 9P21_3_MG_459 rs7865618 9 98.9% A/A 128 (32%) 640 (32%) 768 1.049
(0.896, 1.228)		 0.55064 0.92508
A/G 207 (52%) 978 (49%) 1185
G/G 66 (16%) 366 (18%) 432
26 PSRC1_MG_460 rs599839 1 99.4% A/A 229 (57%) 1148 (57%) 1377 1.048
(0.873, 1.258)		 0.61474 0.93254
A/G 153 (38%) 723 (36%) 876
G/G 18 (4%) 127 (6%) 145
27 CELSR2_MG_434 rs413380 1 99.5% C/C 369 (91%) 1812 (91%) 2181 1.080
(0.750, 1.554)		 0.68054 0.93254
C/T 34 (8%) 175 (9%) 209
T/T 1 (0%) 10 (1%) 11
28 5Q21_1_MG_441 rs565928 5 99.5% C/C 255 (63%) 1250 (63%) 1505 1.040
(0.859, 1.259)		 0.68755 0.93254
C/T 128 (32%) 641 (32%) 769
T/T 21 (5%) 105 (5%) 126
29 5Q21_1_MG_436 rs449650 5 99.0% G/G 254 (63%) 1248 (63%) 1502 1.039
(0.858, 1.257)		 0.69782 0.93254
G/T 128 (32%) 632 (32%) 760
T/T 21 (5%) 106 (5%) 127
30 SEZ6L_MG_442 rs6005015 22 99.5% C/C 37 (9%) 180 (9%) 217 0.966
(0.803, 1.161)		 0.71069 0.93254
C/T 166 (41%) 864 (43%) 1030
T/T 201 (50%) 953 (48%) 1154
31 SEZ6L_MG_457 rs6005016 22 99.0% A/A 2 (0%) 3 (0%) 5 1.075
(0.718, 1.610)		 0.72561 0.93254
A/G 26 (6%) 139 (7%) 165
G/G 373 (93%) 1844 (93%) 2217
32 5Q21_1_MG_455 rs383830 5 99.0% A/A 21 (5%) 104 (5%) 125 0.967
(0.798, 1.171)		 0.72901 0.93254
A/T 127 (32%) 635 (32%) 762
T/T 253 (63%) 1249 (63%) 1502
33 2Q36_3_MG_433 rs2972147 2 98.7% C/C 167 (41%) 788 (40%) 955 1.022
(0.867, 1.205)		 0.79465 0.93254
C/T 191 (47%) 915 (46%) 1106
T/T 46 (11%) 273 (14%) 319
34 MIA3_MG_430 rs17465637 1 99.2% A/A 30 (7%) 148 (7%) 178 1.023
(0.855, 1.225)		 0.80067 0.93254
A/C 147 (36%) 737 (37%) 884
C/C 226 (56%) 1105 (56%) 1331
35 2Q36_3_MG_447 rs7597168 2 99.4% C/C 230 (57%) 1118 (56%) 1348 0.976
(0.810, 1.177)		 0.80106 0.93254
C/T 150 (37%) 764 (38%) 914
T/T 24 (6%) 112 (6%) 136
36 MTHFD1L_MG_445 rs6922269 6 99.4% A/A 28 (7%) 106 (5%) 134 1.024
(0.841, 1.247)		 0.81411 0.93254
A/G 129 (32%) 698 (35%) 827
G/G 247 (61%) 1189 (60%) 1436
37 10Q11_21_MG_429 rs1746049 10 99.5% C/C 308 (76%) 1523 (76%) 1831 1.025
(0.807, 1.301)		 0.84014 0.93254
C/T 90 (22%) 441 (22%) 531
T/T 6 (1%) 33 (2%) 39
38 1Q31_2_MG_453 rs1936982 1 99.0% C/C 44 (11%) 258 (13%) 302 1.015
(0.863, 1.195)		 0.85459 0.93254
C/T 185 (46%) 863 (43%) 1048
T/T 172 (43%) 867 (44%) 1039
39 SMAD3_MG_431 rs1866317 15 99.5% C/C 7 (2%) 32 (2%) 39 1.020
(0.807, 1.291)		 0.86593 0.93254
C/G 101 (25%) 471 (24%) 572
G/G 296 (73%) 1494 (75%) 1790
40 CELSR2_MG_438 rs4970834 1 99.5% C/C 254 (63%) 1244 (62%) 1498 1.013
(0.825, 1.242)		 0.90389 0.94708
C/T 133 (33%) 668 (33%) 801
T/T 17 (4%) 83 (4%) 100
41 2Q36_3_MG_461 rs2943634 2 97.3% A/A 44 (11%) 249 (13%) 293 0.992
(0.836, 1.177)		 0.92453 0.94708
A/C 178 (46%) 895 (46%) 1073
C/C 167 (43%) 813 (42%) 980
42 9P21_3_MG_437 rs496892 9 99.0% C/C 96 (24%) 492 (25%) 588 0.996
(0.849, 1.168)		 0.95978 0.95978
C/T 215 (53%) 1034 (52%) 1249
T/T 92 (23%) 458 (23%) 550

stratified by sex, adjusted for: cohort nonhdl hdla bmi bpm dsmoker hisdiab1

Updated on 2008-12-08