Cox regression for STROKE1 endpoint, test for multiplicative allele effects, men and women

rank SNP RS-code Chromosome Success Genotype Cases Non-cases Total HR (95% CI) nominal p-value tail-area FDR
1 10Q11_21_MG_432 rs2146807 10 99.4% C/C 2 (0%) 14 (1%) 16 0.759
(0.570, 1.010)		 0.05862 0.52511
C/T 75 (14%) 325 (17%) 400
T/T 463 (86%) 1625 (83%) 2088
2 10Q11_21_MG_458 rs622472 10 98.3% A/A 380 (72%) 1363 (70%) 1743 1.191
(0.979, 1.450)		 0.08118 0.52511
A/C 141 (27%) 530 (27%) 671
C/C 10 (2%) 53 (3%) 63
3 10Q11_21_MG_440 rs559580 10 99.2% C/C 10 (2%) 51 (3%) 61 0.840
(0.689, 1.023)		 0.08336 0.52511
C/T 141 (26%) 527 (27%) 668
T/T 388 (72%) 1382 (71%) 1770
4 10Q11_21_MG_456 rs513391 10 99.0% A/A 384 (72%) 1379 (70%) 1763 1.190
(0.977, 1.449)		 0.08433 0.52511
A/C 140 (26%) 530 (27%) 670
C/C 10 (2%) 52 (3%) 62
5 10Q11_21_MG_443 rs687175 10 99.5% C/C 10 (2%) 51 (3%) 61 0.841
(0.691, 1.025)		 0.08579 0.52511
C/T 142 (26%) 532 (27%) 674
T/T 388 (72%) 1384 (70%) 1772
6 9P21_3_MG_425 rs1333049 9 99.6% C/C 102 (19%) 335 (17%) 437 1.132
(0.980, 1.308)		 0.09139 0.52511
C/G 265 (49%) 961 (49%) 1226
G/G 173 (32%) 674 (34%) 847
7 10Q11_21_MG_428 rs1746048 10 99.5% C/C 388 (72%) 1388 (71%) 1776 1.182
(0.970, 1.440)		 0.09703 0.52511
C/T 142 (26%) 530 (27%) 672
T/T 10 (2%) 50 (3%) 60
8 9P21_3_MG_420 rs10738610 9 99.2% A/A 169 (31%) 656 (33%) 825 0.888
(0.768, 1.026)		 0.10568 0.52511
A/C 265 (49%) 961 (49%) 1226
C/C 103 (19%) 345 (18%) 448
9 10Q11_21_MG_439 rs501120 10 96.8% C/C 10 (2%) 50 (3%) 60 0.848
(0.691, 1.040)		 0.11252 0.52511
C/T 128 (24%) 473 (25%) 601
T/T 388 (74%) 1391 (73%) 1779
10 19Q12_MG_422 rs11670734 19 99.6% C/C 45 (8%) 153 (8%) 198 1.126
(0.959, 1.321)		 0.14650 0.61530
C/G 221 (41%) 803 (41%) 1024
G/G 274 (51%) 1013 (51%) 1287
11 12Q12_MG_448 rs7970834 12 99.5% G/G 155 (29%) 615 (31%) 770 0.898
(0.772, 1.045)		 0.16480 0.62922
G/T 273 (51%) 992 (50%) 1265
T/T 112 (21%) 361 (18%) 473
12 SMAD3_MG_424 rs12913547 15 99.6% C/C 37 (7%) 139 (7%) 176 1.102
(0.940, 1.292)		 0.23162 0.81069
C/T 232 (43%) 761 (39%) 993
T/T 271 (50%) 1070 (54%) 1341
13 MTHFD1L_MG_449 rs12214306 6 99.1% C/C 1 (0%) 1 (0%) 2 0.751
(0.453, 1.245)		 0.26650 0.85611
C/T 20 (4%) 92 (5%) 112
T/T 513 (96%) 1870 (95%) 2383
14 FMN2_MG_450 rs1456648 1 98.5% G/G 17 (3%) 47 (2%) 64 0.901
(0.735, 1.105)		 0.31741 0.85611
G/T 118 (22%) 508 (26%) 626
T/T 397 (75%) 1395 (72%) 1792
15 MIA3_MG_454 rs3008621 1 98.4% A/A 11 (2%) 51 (3%) 62 0.905
(0.740, 1.107)		 0.33207 0.85611
A/G 127 (24%) 471 (24%) 598
G/G 391 (74%) 1428 (73%) 1819
16 9P21_3_MG_421 rs10757283 9 99.3% C/C 141 (26%) 572 (29%) 713 0.933
(0.806, 1.079)		 0.34784 0.85611
C/T 272 (50%) 998 (51%) 1270
T/T 126 (23%) 394 (20%) 520
17 MTHFD1L_MG_423 rs12525353 6 99.4% A/A 0 (0%) 2 (0%) 2 0.789
(0.458, 1.359)		 0.39274 0.85611
A/C 17 (3%) 77 (4%) 94
C/C 522 (97%) 1888 (96%) 2410
18 10Q11_21_MG_429 rs1746049 10 99.6% C/C 414 (77%) 1502 (76%) 1916 1.086
(0.874, 1.350)		 0.45462 0.85611
C/T 119 (22%) 435 (22%) 554
T/T 7 (1%) 32 (2%) 39
19 SEZ6L_MG_427 rs137209 22 99.6% A/A 57 (11%) 196 (10%) 253 0.945
(0.806, 1.106)		 0.47955 0.85611
A/G 227 (42%) 908 (46%) 1135
G/G 256 (47%) 866 (44%) 1122
20 2Q36_3_MG_447 rs7597168 2 99.4% C/C 314 (58%) 1104 (56%) 1418 1.058
(0.892, 1.255)		 0.51663 0.85611
C/T 196 (36%) 751 (38%) 947
T/T 30 (6%) 111 (6%) 141
21 SEZ6L_MG_444 rs688034 22 99.5% C/C 294 (55%) 1028 (52%) 1322 1.055
(0.896, 1.242)		 0.52083 0.85611
C/T 212 (39%) 805 (41%) 1017
T/T 33 (6%) 135 (7%) 168
22 SEZ6L_MG_442 rs6005015 22 99.6% C/C 47 (9%) 177 (9%) 224 0.950
(0.807, 1.119)		 0.54022 0.85611
C/T 227 (42%) 847 (43%) 1074
T/T 266 (49%) 945 (48%) 1211
23 1Q31_2_MG_453 rs1936982 1 98.9% C/C 62 (12%) 255 (13%) 317 1.042
(0.900, 1.205)		 0.58512 0.85611
C/T 245 (46%) 851 (43%) 1096
T/T 226 (42%) 854 (44%) 1080
24 9P21_3_MG_451 rs1537378 9 98.2% A/A 73 (14%) 290 (15%) 363 0.961
(0.831, 1.112)		 0.59540 0.85611
A/G 266 (50%) 944 (49%) 1210
G/G 195 (37%) 706 (36%) 901
25 SEZ6L_MG_426 rs137205 22 99.5% A/A 45 (8%) 150 (8%) 195 0.960
(0.816, 1.129)		 0.62155 0.85611
A/G 214 (40%) 847 (43%) 1061
G/G 280 (52%) 971 (49%) 1251
26 5Q21_1_MG_455 rs383830 5 99.0% A/A 28 (5%) 100 (5%) 128 1.041
(0.881, 1.231)		 0.63590 0.85611
A/T 180 (34%) 621 (32%) 801
T/T 326 (61%) 1239 (63%) 1565
27 9P21_3_MG_437 rs496892 9 99.0% C/C 125 (23%) 489 (25%) 614 0.966
(0.837, 1.115)		 0.63839 0.85611
C/T 287 (53%) 1015 (52%) 1302
T/T 127 (24%) 452 (23%) 579
28 5Q21_1_MG_436 rs449650 5 99.1% G/G 328 (61%) 1239 (63%) 1567 0.963
(0.815, 1.137)		 0.65491 0.85611
G/T 182 (34%) 618 (32%) 800
T/T 28 (5%) 102 (5%) 130
29 2Q36_3_MG_433 rs2972147 2 98.7% C/C 225 (42%) 775 (40%) 1000 1.034
(0.892, 1.200)		 0.65589 0.85611
C/T 250 (46%) 903 (46%) 1153
T/T 65 (12%) 270 (14%) 335
30 PSRC1_MG_460 rs599839 1 99.4% A/A 307 (57%) 1133 (58%) 1440 1.038
(0.880, 1.224)		 0.66158 0.85611
A/G 201 (38%) 712 (36%) 913
G/G 26 (5%) 125 (6%) 151
31 CELSR2_MG_438 rs4970834 1 99.4% C/C 343 (64%) 1229 (62%) 1572 1.042
(0.866, 1.255)		 0.66168 0.85611
C/T 172 (32%) 657 (33%) 829
T/T 23 (4%) 81 (4%) 104
32 SMAD3_MG_452 rs17228212 15 99.0% C/C 29 (5%) 108 (6%) 137 1.040
(0.872, 1.240)		 0.66371 0.85611
C/T 189 (35%) 712 (36%) 901
T/T 316 (59%) 1142 (58%) 1458
33 5Q21_1_MG_441 rs565928 5 99.5% C/C 330 (61%) 1240 (63%) 1570 0.965
(0.816, 1.140)		 0.67266 0.85611
C/T 182 (34%) 627 (32%) 809
T/T 28 (5%) 101 (5%) 129
34 2Q36_3_MG_461 rs2943634 2 97.3% A/A 60 (12%) 246 (13%) 306 0.970
(0.832, 1.131)		 0.69728 0.86135
A/C 236 (45%) 884 (46%) 1120
C/C 225 (43%) 800 (41%) 1025
35 CELSR2_MG_434 rs413380 1 99.6% C/C 494 (91%) 1787 (91%) 2281 1.056
(0.766, 1.455)		 0.74150 0.87959
C/T 44 (8%) 172 (9%) 216
T/T 2 (0%) 10 (1%) 12
36 19Q12_MG_446 rs7250581 19 98.0% A/A 15 (3%) 49 (3%) 64 1.033
(0.845, 1.262)		 0.75394 0.87959
A/G 126 (24%) 456 (24%) 582
G/G 391 (73%) 1433 (74%) 1824
37 5Q21_1_MG_435 rs436495 5 98.8% A/A 37 (7%) 112 (6%) 149 1.014
(0.858, 1.198)		 0.87483 0.95657
A/G 183 (34%) 683 (35%) 866
G/G 314 (59%) 1160 (59%) 1474
38 MIA3_MG_430 rs17465637 1 99.2% A/A 46 (9%) 147 (7%) 193 0.988
(0.838, 1.166)		 0.88926 0.95657
A/C 184 (34%) 730 (37%) 914
C/C 309 (57%) 1085 (55%) 1394
39 SEZ6L_MG_457 rs6005016 22 98.9% A/A 2 (0%) 3 (0%) 5 1.015
(0.705, 1.460)		 0.93806 0.95657
A/G 33 (6%) 138 (7%) 171
G/G 499 (93%) 1817 (93%) 2316
40 9P21_3_MG_459 rs7865618 9 98.8% A/A 164 (31%) 633 (32%) 797 0.995
(0.864, 1.145)		 0.94099 0.95657
A/G 277 (52%) 961 (49%) 1238
G/G 93 (17%) 362 (19%) 455
41 SMAD3_MG_431 rs1866317 15 99.6% C/C 11 (2%) 30 (2%) 41 0.993
(0.801, 1.230)		 0.94731 0.95657
C/G 129 (24%) 465 (24%) 594
G/G 400 (74%) 1474 (75%) 1874
42 MTHFD1L_MG_445 rs6922269 6 99.4% A/A 34 (6%) 104 (5%) 138 0.995
(0.835, 1.186)		 0.95657 0.95657
A/G 176 (33%) 692 (35%) 868
G/G 330 (61%) 1169 (59%) 1499

stratified by sex, adjusted for: cohort nonhdl hdla bmi bpm dsmoker hisdiab1

Updated on 2008-12-08