Cox regression for STROKE2 endpoint, test for multiplicative allele effects, men and women

rank SNP RS-code Chromosome Success Genotype Cases Non-cases Total HR (95% CI) nominal p-value tail-area FDR
1 19Q12_MG_422 rs11670734 19 99.5% C/C 7 (8%) 157 (8%) 164 1.375
(0.993, 1.904)		 0.05552 0.93583
C/G 45 (50%) 833 (41%) 878
G/G 38 (42%) 1061 (52%) 1099
2 19Q12_MG_446 rs7250581 19 98.0% A/A 3 (3%) 52 (3%) 55 1.421
(0.966, 2.091)		 0.07420 0.93583
A/G 28 (31%) 471 (23%) 499
G/G 58 (65%) 1496 (74%) 1554
3 2Q36_3_MG_447 rs7597168 2 99.3% C/C 58 (64%) 1148 (56%) 1206 1.416
(0.950, 2.110)		 0.08771 0.93583
C/T 28 (31%) 782 (38%) 810
T/T 4 (4%) 118 (6%) 122
4 CELSR2_MG_438 rs4970834 1 99.3% C/C 63 (72%) 1280 (62%) 1343 1.482
(0.931, 2.358)		 0.09721 0.93583
C/T 22 (25%) 684 (33%) 706
T/T 3 (3%) 85 (4%) 88
5 12Q12_MG_448 rs7970834 12 99.4% G/G 22 (24%) 638 (31%) 660 0.774
(0.556, 1.078)		 0.12952 0.93583
G/T 47 (52%) 1038 (51%) 1085
T/T 21 (23%) 374 (18%) 395
6 10Q11_21_MG_432 rs2146807 10 99.3% C/C 0 (0%) 15 (1%) 15 0.610
(0.316, 1.178)		 0.14063 0.93583
C/T 10 (11%) 338 (17%) 348
T/T 80 (89%) 1693 (83%) 1773
7 PSRC1_MG_460 rs599839 1 99.5% A/A 55 (61%) 1182 (58%) 1237 1.292
(0.901, 1.854)		 0.16377 0.93583
A/G 33 (37%) 739 (36%) 772
G/G 2 (2%) 130 (6%) 132
8 9P21_3_MG_451 rs1537378 9 98.0% A/A 8 (9%) 304 (15%) 312 0.835
(0.617, 1.130)		 0.24250 0.99535
A/G 46 (52%) 980 (48%) 1026
G/G 34 (39%) 738 (36%) 772
9 MTHFD1L_MG_445 rs6922269 6 99.3% A/A 6 (7%) 108 (5%) 114 1.240
(0.859, 1.791)		 0.25055 0.99535
A/G 36 (40%) 719 (35%) 755
G/G 48 (53%) 1220 (60%) 1268
10 10Q11_21_MG_443 rs687175 10 99.4% C/C 0 (0%) 53 (3%) 53 0.822
(0.540, 1.249)		 0.35765 0.99535
C/T 25 (28%) 559 (27%) 584
T/T 65 (72%) 1437 (70%) 1502
11 10Q11_21_MG_458 rs622472 10 98.3% A/A 63 (72%) 1415 (70%) 1478 1.215
(0.802, 1.841)		 0.35772 0.99535
A/C 25 (28%) 557 (27%) 582
C/C 0 (0%) 55 (3%) 55
12 10Q11_21_MG_428 rs1746048 10 99.4% C/C 65 (72%) 1441 (70%) 1506 1.214
(0.799, 1.847)		 0.36338 0.99535
C/T 25 (28%) 557 (27%) 582
T/T 0 (0%) 52 (3%) 52
13 10Q11_21_MG_440 rs559580 10 99.0% C/C 0 (0%) 53 (3%) 53 0.837
(0.551, 1.271)		 0.40331 0.99535
C/T 25 (28%) 553 (27%) 578
T/T 64 (72%) 1436 (70%) 1500
14 10Q11_21_MG_456 rs513391 10 99.0% A/A 63 (72%) 1432 (70%) 1495 1.188
(0.781, 1.807)		 0.42034 0.99535
A/C 25 (28%) 557 (27%) 582
C/C 0 (0%) 54 (3%) 54
15 SEZ6L_MG_444 rs688034 22 99.4% C/C 47 (52%) 1066 (52%) 1113 0.877
(0.620, 1.240)		 0.45741 0.99535
C/T 32 (36%) 846 (41%) 878
T/T 11 (12%) 138 (7%) 149
16 CELSR2_MG_434 rs413380 1 99.5% C/C 84 (93%) 1864 (91%) 1948 1.316
(0.617, 2.804)		 0.47723 0.99535
C/T 6 (7%) 177 (9%) 183
T/T 0 (0%) 10 (0%) 10
17 9P21_3_MG_420 rs10738610 9 99.1% A/A 28 (31%) 686 (34%) 714 0.903
(0.666, 1.224)		 0.51172 0.99535
A/C 45 (50%) 1001 (49%) 1046
C/C 17 (19%) 356 (17%) 373
18 9P21_3_MG_437 rs496892 9 98.9% C/C 24 (27%) 509 (25%) 533 1.108
(0.809, 1.517)		 0.52427 0.99535
C/T 47 (52%) 1050 (52%) 1097
T/T 19 (21%) 479 (24%) 498
19 9P21_3_MG_459 rs7865618 9 98.8% A/A 30 (34%) 662 (32%) 692 1.093
(0.803, 1.488)		 0.57087 0.99535
A/G 45 (51%) 995 (49%) 1040
G/G 13 (15%) 381 (19%) 394
20 MIA3_MG_430 rs17465637 1 99.2% A/A 12 (13%) 150 (7%) 162 0.891
(0.583, 1.360)		 0.59159 0.99535
A/C 20 (22%) 757 (37%) 777
C/C 58 (64%) 1137 (56%) 1195
21 10Q11_21_MG_439 rs501120 10 96.7% C/C 0 (0%) 52 (3%) 52 0.905
(0.600, 1.365)		 0.63319 0.99535
C/T 25 (28%) 495 (25%) 520
T/T 65 (72%) 1444 (73%) 1509
22 SEZ6L_MG_426 rs137205 22 99.4% A/A 9 (10%) 157 (8%) 166 1.073
(0.780, 1.476)		 0.66475 0.99535
A/G 39 (43%) 889 (43%) 928
G/G 42 (47%) 1004 (49%) 1046
23 10Q11_21_MG_429 rs1746049 10 99.5% C/C 69 (77%) 1559 (76%) 1628 1.105
(0.701, 1.740)		 0.66740 0.99535
C/T 21 (23%) 458 (22%) 479
T/T 0 (0%) 34 (2%) 34
24 SMAD3_MG_424 rs12913547 15 99.5% C/C 7 (8%) 143 (7%) 150 1.071
(0.758, 1.515)		 0.69638 0.99535
C/T 37 (41%) 799 (39%) 836
T/T 46 (51%) 1110 (54%) 1156
25 SEZ6L_MG_442 rs6005015 22 99.5% C/C 7 (8%) 184 (9%) 191 0.940
(0.671, 1.315)		 0.71613 0.99535
C/T 39 (43%) 883 (43%) 922
T/T 44 (49%) 984 (48%) 1028
26 9P21_3_MG_425 rs1333049 9 99.5% C/C 16 (18%) 346 (17%) 362 1.053
(0.773, 1.434)		 0.74297 0.99535
C/G 44 (49%) 1001 (49%) 1045
G/G 30 (33%) 705 (34%) 735
27 5Q21_1_MG_441 rs565928 5 99.4% C/C 55 (61%) 1290 (63%) 1345 1.047
(0.734, 1.495)		 0.79892 0.99535
C/T 32 (36%) 652 (32%) 684
T/T 3 (3%) 108 (5%) 111
28 2Q36_3_MG_461 rs2943634 2 97.3% A/A 14 (16%) 251 (13%) 265 0.958
(0.671, 1.367)		 0.81166 0.99535
A/C 34 (38%) 917 (46%) 951
C/C 41 (46%) 837 (42%) 878
29 2Q36_3_MG_433 rs2972147 2 98.5% C/C 38 (42%) 814 (40%) 852 0.962
(0.682, 1.357)		 0.82546 0.99535
C/T 36 (40%) 941 (46%) 977
T/T 16 (18%) 275 (14%) 291
30 5Q21_1_MG_436 rs449650 5 99.0% G/G 54 (61%) 1289 (63%) 1343 1.040
(0.730, 1.482)		 0.82773 0.99535
G/T 32 (36%) 643 (32%) 675
T/T 3 (3%) 109 (5%) 112
31 SEZ6L_MG_457 rs6005016 22 98.9% A/A 0 (0%) 4 (0%) 4 1.078
(0.514, 2.260)		 0.84288 0.99535
A/G 7 (8%) 142 (7%) 149
G/G 81 (92%) 1894 (93%) 1975
32 SMAD3_MG_431 rs1866317 15 99.5% C/C 3 (3%) 30 (1%) 33 0.963
(0.578, 1.605)		 0.88508 0.99535
C/G 18 (20%) 485 (24%) 503
G/G 69 (77%) 1536 (75%) 1605
33 FMN2_MG_450 rs1456648 1 98.5% G/G 2 (2%) 49 (2%) 51 1.024
(0.672, 1.562)		 0.91123 0.99535
G/T 23 (26%) 525 (26%) 548
T/T 63 (72%) 1458 (72%) 1521
34 9P21_3_MG_421 rs10757283 9 99.3% C/C 26 (29%) 599 (29%) 625 0.983
(0.708, 1.364)		 0.91886 0.99535
C/T 44 (49%) 1028 (50%) 1072
T/T 20 (22%) 419 (20%) 439
35 5Q21_1_MG_455 rs383830 5 99.0% A/A 3 (3%) 107 (5%) 110 0.984
(0.691, 1.400)		 0.92691 0.99535
A/T 32 (36%) 646 (32%) 678
T/T 53 (60%) 1289 (63%) 1342
36 MIA3_MG_454 rs3008621 1 98.5% A/A 3 (3%) 53 (3%) 56 1.016
(0.658, 1.571)		 0.94178 0.99535
A/G 22 (25%) 490 (24%) 512
G/G 63 (72%) 1489 (73%) 1552
37 SEZ6L_MG_427 rs137209 22 99.5% A/A 11 (12%) 205 (10%) 216 1.005
(0.728, 1.388)		 0.97527 0.99535
A/G 40 (44%) 949 (46%) 989
G/G 39 (43%) 898 (44%) 937
38 1Q31_2_MG_453 rs1936982 1 99.0% C/C 12 (14%) 264 (13%) 276 0.998
(0.711, 1.401)		 0.99202 0.99535
C/T 36 (41%) 891 (44%) 927
T/T 40 (45%) 887 (43%) 927
39 SMAD3_MG_452 rs17228212 15 99.1% C/C 5 (6%) 110 (5%) 115 1.001
(0.676, 1.483)		 0.99497 0.99535
C/T 30 (34%) 740 (36%) 770
T/T 53 (60%) 1194 (58%) 1247
40 5Q21_1_MG_435 rs436495 5 98.8% A/A 4 (4%) 121 (6%) 125 0.999
(0.709, 1.408)		 0.99535 0.99535
A/G 35 (39%) 708 (35%) 743
G/G 51 (57%) 1207 (59%) 1258

Updated on 2008-12-08