Cox regression for STROKE2 endpoint, test for multiplicative allele effects, men and women

rank SNP RS-code Chromosome Success Genotype Cases Non-cases Total HR (95% CI) nominal p-value tail-area FDR
1 19Q12_MG_422 rs11670734 19 99.5% C/C 7 (8%) 157 (8%) 164 1.376
(1.003, 1.887)		 0.04791 0.97357
C/G 45 (50%) 833 (41%) 878
G/G 38 (42%) 1061 (52%) 1099
2 19Q12_MG_446 rs7250581 19 98.0% A/A 3 (3%) 52 (3%) 55 1.449
(0.989, 2.122)		 0.05680 0.97357
A/G 28 (31%) 471 (23%) 499
G/G 58 (65%) 1496 (74%) 1554
3 12Q12_MG_448 rs7970834 12 99.4% G/G 22 (24%) 638 (31%) 660 0.777
(0.571, 1.057)		 0.10800 0.97357
G/T 47 (52%) 1038 (51%) 1085
T/T 21 (23%) 374 (18%) 395
4 CELSR2_MG_438 rs4970834 1 99.3% C/C 63 (72%) 1280 (62%) 1343 1.393
(0.902, 2.151)		 0.13520 0.97357
C/T 22 (25%) 684 (33%) 706
T/T 3 (3%) 85 (4%) 88
5 10Q11_21_MG_432 rs2146807 10 99.3% C/C 0 (0%) 15 (1%) 15 0.638
(0.340, 1.197)		 0.16178 0.97357
C/T 10 (11%) 338 (17%) 348
T/T 80 (89%) 1693 (83%) 1773
6 2Q36_3_MG_447 rs7597168 2 99.3% C/C 58 (64%) 1148 (56%) 1206 1.307
(0.891, 1.917)		 0.17038 0.97357
C/T 28 (31%) 782 (38%) 810
T/T 4 (4%) 118 (6%) 122
7 MTHFD1L_MG_445 rs6922269 6 99.3% A/A 6 (7%) 108 (5%) 114 1.271
(0.895, 1.804)		 0.17989 0.97357
A/G 36 (40%) 719 (35%) 755
G/G 48 (53%) 1220 (60%) 1268
8 PSRC1_MG_460 rs599839 1 99.5% A/A 55 (61%) 1182 (58%) 1237 1.237
(0.879, 1.740)		 0.22176 0.97357
A/G 33 (37%) 739 (36%) 772
G/G 2 (2%) 130 (6%) 132
9 9P21_3_MG_451 rs1537378 9 98.0% A/A 8 (9%) 304 (15%) 312 0.847
(0.621, 1.154)		 0.29228 0.97357
A/G 46 (52%) 980 (48%) 1026
G/G 34 (39%) 738 (36%) 772
10 CELSR2_MG_434 rs413380 1 99.5% C/C 84 (93%) 1864 (91%) 1948 1.400
(0.659, 2.978)		 0.38172 0.97357
C/T 6 (7%) 177 (9%) 183
T/T 0 (0%) 10 (0%) 10
11 10Q11_21_MG_443 rs687175 10 99.4% C/C 0 (0%) 53 (3%) 53 0.839
(0.557, 1.263)		 0.40024 0.97357
C/T 25 (28%) 559 (27%) 584
T/T 65 (72%) 1437 (70%) 1502
12 10Q11_21_MG_428 rs1746048 10 99.4% C/C 65 (72%) 1441 (70%) 1506 1.188
(0.788, 1.790)		 0.41111 0.97357
C/T 25 (28%) 557 (27%) 582
T/T 0 (0%) 52 (3%) 52
13 10Q11_21_MG_458 rs622472 10 98.3% A/A 63 (72%) 1415 (70%) 1478 1.183
(0.787, 1.779)		 0.41838 0.97357
A/C 25 (28%) 557 (27%) 582
C/C 0 (0%) 55 (3%) 55
14 SEZ6L_MG_444 rs688034 22 99.4% C/C 47 (52%) 1066 (52%) 1113 0.866
(0.605, 1.240)		 0.43256 0.97357
C/T 32 (36%) 846 (41%) 878
T/T 11 (12%) 138 (7%) 149
15 10Q11_21_MG_440 rs559580 10 99.0% C/C 0 (0%) 53 (3%) 53 0.854
(0.567, 1.286)		 0.44894 0.97357
C/T 25 (28%) 553 (27%) 578
T/T 64 (72%) 1436 (70%) 1500
16 10Q11_21_MG_456 rs513391 10 99.0% A/A 63 (72%) 1432 (70%) 1495 1.163
(0.772, 1.753)		 0.46986 0.97357
A/C 25 (28%) 557 (27%) 582
C/C 0 (0%) 54 (3%) 54
17 9P21_3_MG_420 rs10738610 9 99.1% A/A 28 (31%) 686 (34%) 714 0.895
(0.661, 1.211)		 0.47186 0.97357
A/C 45 (50%) 1001 (49%) 1046
C/C 17 (19%) 356 (17%) 373
18 SEZ6L_MG_426 rs137205 22 99.4% A/A 9 (10%) 157 (8%) 166 1.109
(0.797, 1.543)		 0.53934 0.97357
A/G 39 (43%) 889 (43%) 928
G/G 42 (47%) 1004 (49%) 1046
19 9P21_3_MG_459 rs7865618 9 98.8% A/A 30 (34%) 662 (32%) 692 1.095
(0.806, 1.488)		 0.56007 0.97357
A/G 45 (51%) 995 (49%) 1040
G/G 13 (15%) 381 (19%) 394
20 SMAD3_MG_424 rs12913547 15 99.5% C/C 7 (8%) 143 (7%) 150 1.090
(0.778, 1.526)		 0.61741 0.97357
C/T 37 (41%) 799 (39%) 836
T/T 46 (51%) 1110 (54%) 1156
21 10Q11_21_MG_429 rs1746049 10 99.5% C/C 69 (77%) 1559 (76%) 1628 1.110
(0.713, 1.729)		 0.64295 0.97357
C/T 21 (23%) 458 (22%) 479
T/T 0 (0%) 34 (2%) 34
22 MIA3_MG_430 rs17465637 1 99.2% A/A 12 (13%) 150 (7%) 162 0.911
(0.606, 1.368)		 0.65191 0.97357
A/C 20 (22%) 757 (37%) 777
C/C 58 (64%) 1137 (56%) 1195
23 9P21_3_MG_425 rs1333049 9 99.5% C/C 16 (18%) 346 (17%) 362 1.071
(0.789, 1.453)		 0.66105 0.97357
C/G 44 (49%) 1001 (49%) 1045
G/G 30 (33%) 705 (34%) 735
24 2Q36_3_MG_433 rs2972147 2 98.5% C/C 38 (42%) 814 (40%) 852 0.932
(0.671, 1.295)		 0.67638 0.97357
C/T 36 (40%) 941 (46%) 977
T/T 16 (18%) 275 (14%) 291
25 9P21_3_MG_437 rs496892 9 98.9% C/C 24 (27%) 509 (25%) 533 1.063
(0.789, 1.431)		 0.68869 0.97357
C/T 47 (52%) 1050 (52%) 1097
T/T 19 (21%) 479 (24%) 498
26 SEZ6L_MG_442 rs6005015 22 99.5% C/C 7 (8%) 184 (9%) 191 0.935
(0.662, 1.320)		 0.70258 0.97357
C/T 39 (43%) 883 (43%) 922
T/T 44 (49%) 984 (48%) 1028
27 SEZ6L_MG_427 rs137209 22 99.5% A/A 11 (12%) 205 (10%) 216 1.060
(0.762, 1.475)		 0.72890 0.97357
A/G 40 (44%) 949 (46%) 989
G/G 39 (43%) 898 (44%) 937
28 5Q21_1_MG_441 rs565928 5 99.4% C/C 55 (61%) 1290 (63%) 1345 1.063
(0.745, 1.517)		 0.73563 0.97357
C/T 32 (36%) 652 (32%) 684
T/T 3 (3%) 108 (5%) 111
29 9P21_3_MG_421 rs10757283 9 99.3% C/C 26 (29%) 599 (29%) 625 0.950
(0.694, 1.299)		 0.74782 0.97357
C/T 44 (49%) 1028 (50%) 1072
T/T 20 (22%) 419 (20%) 439
30 SMAD3_MG_431 rs1866317 15 99.5% C/C 3 (3%) 30 (1%) 33 0.929
(0.573, 1.506)		 0.76421 0.97357
C/G 18 (20%) 485 (24%) 503
G/G 69 (77%) 1536 (75%) 1605
31 10Q11_21_MG_439 rs501120 10 96.7% C/C 0 (0%) 52 (3%) 52 0.945
(0.636, 1.405)		 0.78089 0.97357
C/T 25 (28%) 495 (25%) 520
T/T 65 (72%) 1444 (73%) 1509
32 5Q21_1_MG_436 rs449650 5 99.0% G/G 54 (61%) 1289 (63%) 1343 1.048
(0.736, 1.494)		 0.79324 0.97357
G/T 32 (36%) 643 (32%) 675
T/T 3 (3%) 109 (5%) 112
33 SEZ6L_MG_457 rs6005016 22 98.9% A/A 0 (0%) 4 (0%) 4 1.066
(0.518, 2.194)		 0.86314 0.97357
A/G 7 (8%) 142 (7%) 149
G/G 81 (92%) 1894 (93%) 1975
34 5Q21_1_MG_435 rs436495 5 98.8% A/A 4 (4%) 121 (6%) 125 0.971
(0.688, 1.369)		 0.86601 0.97357
A/G 35 (39%) 708 (35%) 743
G/G 51 (57%) 1207 (59%) 1258
35 5Q21_1_MG_455 rs383830 5 99.0% A/A 3 (3%) 107 (5%) 110 0.971
(0.681, 1.385)		 0.87229 0.97357
A/T 32 (36%) 646 (32%) 678
T/T 53 (60%) 1289 (63%) 1342
36 MIA3_MG_454 rs3008621 1 98.5% A/A 3 (3%) 53 (3%) 56 1.030
(0.670, 1.583)		 0.89204 0.97357
A/G 22 (25%) 490 (24%) 512
G/G 63 (72%) 1489 (73%) 1552
37 FMN2_MG_450 rs1456648 1 98.5% G/G 2 (2%) 49 (2%) 51 0.973
(0.637, 1.487)		 0.90101 0.97357
G/T 23 (26%) 525 (26%) 548
T/T 63 (72%) 1458 (72%) 1521
38 1Q31_2_MG_453 rs1936982 1 99.0% C/C 12 (14%) 264 (13%) 276 0.988
(0.712, 1.371)		 0.94378 0.97357
C/T 36 (41%) 891 (44%) 927
T/T 40 (45%) 887 (43%) 927
39 SMAD3_MG_452 rs17228212 15 99.1% C/C 5 (6%) 110 (5%) 115 1.010
(0.687, 1.484)		 0.96015 0.97357
C/T 30 (34%) 740 (36%) 770
T/T 53 (60%) 1194 (58%) 1247
40 2Q36_3_MG_461 rs2943634 2 97.3% A/A 14 (16%) 251 (13%) 265 0.994
(0.710, 1.393)		 0.97357 0.97357
A/C 34 (38%) 917 (46%) 951
C/C 41 (46%) 837 (42%) 878

stratified by sex, adjusted for: cohort dsmoker

Updated on 2008-12-08