Cox regression for STROKE3 endpoint, test for multiplicative allele effects, men and women

rank SNP RS-code Chromosome Success Genotype Cases Non-cases Total HR (95% CI) nominal p-value tail-area FDR
1 19Q12_MG_422 rs11670734 19 99.5% C/C 38 (9%) 154 (8%) 192 1.156
(0.970, 1.377)		 0.10587 0.77343
C/G 173 (41%) 810 (41%) 983
G/G 214 (50%) 1027 (52%) 1241
2 10Q11_21_MG_458 rs622472 10 98.4% A/A 300 (72%) 1377 (70%) 1677 1.165
(0.941, 1.442)		 0.16131 0.77343
A/C 110 (26%) 537 (27%) 647
C/C 9 (2%) 54 (3%) 63
3 9P21_3_MG_425 rs1333049 9 99.6% C/C 79 (19%) 337 (17%) 416 1.112
(0.952, 1.299)		 0.18173 0.77343
C/G 209 (49%) 974 (49%) 1183
G/G 137 (32%) 681 (34%) 818
4 10Q11_21_MG_456 rs513391 10 99.1% A/A 302 (72%) 1393 (70%) 1695 1.154
(0.932, 1.429)		 0.18856 0.77343
A/C 110 (26%) 537 (27%) 647
C/C 9 (2%) 53 (3%) 62
5 9P21_3_MG_420 rs10738610 9 99.1% A/A 134 (32%) 664 (33%) 798 0.904
(0.773, 1.056)		 0.20301 0.77343
A/C 208 (49%) 973 (49%) 1181
C/C 80 (19%) 347 (17%) 427
6 10Q11_21_MG_440 rs559580 10 99.1% C/C 9 (2%) 52 (3%) 61 0.871
(0.704, 1.078)		 0.20429 0.77343
C/T 111 (26%) 534 (27%) 645
T/T 304 (72%) 1396 (70%) 1700
7 MTHFD1L_MG_423 rs12525353 6 99.4% A/A 0 (0%) 2 (0%) 2 0.664
(0.351, 1.256)		 0.20757 0.77343
A/C 12 (3%) 78 (4%) 90
C/C 412 (97%) 1909 (96%) 2321
8 9P21_3_MG_421 rs10757283 9 99.3% C/C 108 (25%) 579 (29%) 687 0.905
(0.773, 1.059)		 0.21312 0.77343
C/T 217 (51%) 1006 (51%) 1223
T/T 99 (23%) 401 (20%) 500
9 10Q11_21_MG_443 rs687175 10 99.5% C/C 9 (2%) 52 (3%) 61 0.874
(0.706, 1.081)		 0.21337 0.77343
C/T 112 (26%) 539 (27%) 651
T/T 304 (72%) 1398 (70%) 1702
10 SEZ6L_MG_427 rs137209 22 99.6% A/A 45 (11%) 198 (10%) 243 0.896
(0.751, 1.068)		 0.22023 0.77343
A/G 170 (40%) 922 (46%) 1092
G/G 210 (49%) 872 (44%) 1082
11 10Q11_21_MG_439 rs501120 10 96.7% C/C 9 (2%) 51 (3%) 60 0.874
(0.701, 1.090)		 0.23252 0.77343
C/T 99 (24%) 479 (25%) 578
T/T 304 (74%) 1405 (73%) 1709
12 10Q11_21_MG_428 rs1746048 10 99.5% C/C 304 (72%) 1402 (70%) 1706 1.137
(0.919, 1.407)		 0.23841 0.77343
C/T 112 (26%) 537 (27%) 649
T/T 9 (2%) 51 (3%) 60
13 FMN2_MG_450 rs1456648 1 98.6% G/G 13 (3%) 47 (2%) 60 0.873
(0.695, 1.095)		 0.23940 0.77343
G/T 91 (22%) 511 (26%) 602
T/T 316 (75%) 1414 (72%) 1730
14 9P21_3_MG_451 rs1537378 9 98.2% A/A 54 (13%) 293 (15%) 347 0.917
(0.781, 1.075)		 0.28596 0.85789
A/G 208 (49%) 955 (49%) 1163
G/G 159 (38%) 714 (36%) 873
15 10Q11_21_MG_432 rs2146807 10 99.3% C/C 2 (0%) 14 (1%) 16 0.872
(0.646, 1.178)		 0.37231 0.95128
C/T 64 (15%) 327 (16%) 391
T/T 359 (84%) 1645 (83%) 2004
16 SEZ6L_MG_444 rs688034 22 99.5% C/C 238 (56%) 1038 (52%) 1276 1.083
(0.903, 1.297)		 0.39006 0.95128
C/T 159 (38%) 817 (41%) 976
T/T 27 (6%) 135 (7%) 162
17 MTHFD1L_MG_449 rs12214306 6 99.1% C/C 1 (0%) 1 (0%) 2 0.806
(0.465, 1.397)		 0.44245 0.95128
C/T 16 (4%) 93 (5%) 109
T/T 404 (96%) 1891 (95%) 2295
18 SMAD3_MG_431 rs1866317 15 99.5% C/C 9 (2%) 30 (2%) 39 1.084
(0.864, 1.359)		 0.48743 0.95128
C/G 108 (25%) 470 (24%) 578
G/G 308 (72%) 1491 (75%) 1799
19 12Q12_MG_448 rs7970834 12 99.5% G/G 127 (30%) 619 (31%) 746 0.950
(0.806, 1.119)		 0.54032 0.95128
G/T 215 (51%) 1005 (51%) 1220
T/T 83 (20%) 366 (18%) 449
20 9P21_3_MG_459 rs7865618 9 98.8% A/A 136 (32%) 639 (32%) 775 1.049
(0.899, 1.224)		 0.54032 0.95128
A/G 216 (51%) 974 (49%) 1190
G/G 69 (16%) 365 (18%) 434
21 SEZ6L_MG_426 rs137205 22 99.5% A/A 38 (9%) 150 (8%) 188 0.946
(0.790, 1.132)		 0.54160 0.95128
A/G 161 (38%) 861 (43%) 1022
G/G 226 (53%) 979 (49%) 1205
22 CELSR2_MG_434 rs413380 1 99.5% C/C 389 (92%) 1807 (91%) 2196 1.105
(0.773, 1.581)		 0.58278 0.95128
C/T 35 (8%) 174 (9%) 209
T/T 1 (0%) 10 (1%) 11
23 PSRC1_MG_460 rs599839 1 99.4% A/A 242 (57%) 1144 (57%) 1386 1.047
(0.875, 1.252)		 0.61831 0.95128
A/G 159 (38%) 721 (36%) 880
G/G 20 (5%) 127 (6%) 147
24 19Q12_MG_446 rs7250581 19 98.0% A/A 11 (3%) 50 (3%) 61 1.055
(0.848, 1.313)		 0.63132 0.95128
A/G 102 (24%) 461 (24%) 563
G/G 306 (73%) 1449 (74%) 1755
25 MIA3_MG_454 rs3008621 1 98.5% A/A 11 (3%) 51 (3%) 62 0.949
(0.763, 1.179)		 0.63461 0.95128
A/G 101 (24%) 477 (24%) 578
G/G 307 (73%) 1444 (73%) 1751
26 SMAD3_MG_424 rs12913547 15 99.6% C/C 24 (6%) 141 (7%) 165 1.043
(0.877, 1.239)		 0.63562 0.95128
C/T 183 (43%) 771 (39%) 954
T/T 218 (51%) 1080 (54%) 1298
27 1Q31_2_MG_453 rs1936982 1 99.0% C/C 49 (12%) 258 (13%) 307 1.037
(0.884, 1.216)		 0.65902 0.95128
C/T 193 (46%) 860 (43%) 1053
T/T 179 (43%) 864 (44%) 1043
28 SEZ6L_MG_457 rs6005016 22 98.9% A/A 2 (0%) 3 (0%) 5 1.082
(0.736, 1.591)		 0.68746 0.95128
A/G 28 (7%) 138 (7%) 166
G/G 391 (93%) 1839 (93%) 2230
29 5Q21_1_MG_435 rs436495 5 98.8% A/A 30 (7%) 116 (6%) 146 0.969
(0.806, 1.166)		 0.74133 0.95128
A/G 139 (33%) 691 (35%) 830
G/G 252 (60%) 1169 (59%) 1421
30 MIA3_MG_430 rs17465637 1 99.2% A/A 36 (8%) 148 (7%) 184 1.028
(0.861, 1.228)		 0.75699 0.95128
A/C 149 (35%) 735 (37%) 884
C/C 239 (56%) 1101 (55%) 1340
31 2Q36_3_MG_461 rs2943634 2 97.3% A/A 50 (12%) 246 (13%) 296 1.025
(0.868, 1.211)		 0.76764 0.95128
A/C 187 (46%) 893 (46%) 1080
C/C 172 (42%) 813 (42%) 985
32 2Q36_3_MG_433 rs2972147 2 98.7% C/C 170 (40%) 788 (40%) 958 0.980
(0.836, 1.149)		 0.80208 0.95128
C/T 203 (48%) 912 (46%) 1115
T/T 52 (12%) 270 (14%) 322
33 SMAD3_MG_452 rs17228212 15 99.1% C/C 22 (5%) 108 (5%) 130 1.020
(0.841, 1.238)		 0.83969 0.95128
C/T 149 (35%) 721 (36%) 870
T/T 250 (59%) 1155 (58%) 1405
34 9P21_3_MG_437 rs496892 9 99.0% C/C 103 (24%) 491 (25%) 594 1.016
(0.870, 1.187)		 0.84014 0.95128
C/T 227 (54%) 1029 (52%) 1256
T/T 94 (22%) 458 (23%) 552
35 5Q21_1_MG_441 rs565928 5 99.5% C/C 266 (63%) 1249 (63%) 1515 1.019
(0.847, 1.227)		 0.84141 0.95128
C/T 136 (32%) 637 (32%) 773
T/T 23 (5%) 104 (5%) 127
36 SEZ6L_MG_442 rs6005015 22 99.5% C/C 39 (9%) 179 (9%) 218 0.983
(0.822, 1.176)		 0.85311 0.95128
C/T 177 (42%) 859 (43%) 1036
T/T 209 (49%) 953 (48%) 1162
37 5Q21_1_MG_436 rs449650 5 99.1% G/G 264 (62%) 1248 (63%) 1512 1.015
(0.844, 1.222)		 0.87098 0.95128
G/T 136 (32%) 628 (32%) 764
T/T 23 (5%) 105 (5%) 128
38 2Q36_3_MG_447 rs7597168 2 99.4% C/C 241 (57%) 1118 (56%) 1359 0.986
(0.822, 1.182)		 0.87524 0.95128
C/T 159 (37%) 758 (38%) 917
T/T 25 (6%) 112 (6%) 137
39 5Q21_1_MG_455 rs383830 5 99.0% A/A 23 (5%) 103 (5%) 126 0.989
(0.821, 1.190)		 0.90358 0.95128
A/T 135 (32%) 631 (32%) 766
T/T 263 (62%) 1248 (63%) 1511
40 10Q11_21_MG_429 rs1746049 10 99.5% C/C 323 (76%) 1518 (76%) 1841 1.013
(0.804, 1.276)		 0.91328 0.95128
C/T 96 (23%) 440 (22%) 536
T/T 6 (1%) 33 (2%) 39
41 CELSR2_MG_438 rs4970834 1 99.5% C/C 268 (63%) 1240 (62%) 1508 1.009
(0.826, 1.232)		 0.92863 0.95128
C/T 138 (32%) 666 (33%) 804
T/T 19 (4%) 83 (4%) 102
42 MTHFD1L_MG_445 rs6922269 6 99.4% A/A 28 (7%) 105 (5%) 133 0.997
(0.822, 1.209)		 0.97362 0.97362
A/G 135 (32%) 698 (35%) 833
G/G 262 (62%) 1184 (60%) 1446

stratified by sex, adjusted for: cohort nonhdl hdla bmi bpm dsmoker hisdiab1

Updated on 2008-12-08