Cox regression for STROKE4 endpoint, test for multiplicative allele effects, men and women

rank SNP RS-code Chromosome Success Genotype Cases Non-cases Total HR (95% CI) nominal p-value tail-area FDR
1 19Q12_MG_422 rs11670734 19 99.5% C/C 39 (9%) 153 (8%) 192 1.162
(0.977, 1.381)		 0.08903 0.72109
C/G 179 (41%) 809 (41%) 988
G/G 219 (50%) 1026 (52%) 1245
2 10Q11_21_MG_458 rs622472 10 98.3% A/A 310 (72%) 1374 (70%) 1684 1.194
(0.965, 1.477)		 0.10223 0.72109
A/C 111 (26%) 537 (27%) 648
C/C 9 (2%) 54 (3%) 63
3 10Q11_21_MG_456 rs513391 10 99.0% A/A 312 (72%) 1390 (70%) 1702 1.183
(0.956, 1.464)		 0.12179 0.72109
A/C 111 (26%) 537 (27%) 648
C/C 9 (2%) 53 (3%) 62
4 10Q11_21_MG_440 rs559580 10 99.1% C/C 9 (2%) 52 (3%) 61 0.848
(0.686, 1.049)		 0.12894 0.72109
C/T 112 (26%) 534 (27%) 646
T/T 315 (72%) 1393 (70%) 1708
5 10Q11_21_MG_443 rs687175 10 99.5% C/C 9 (2%) 52 (3%) 61 0.851
(0.689, 1.052)		 0.13563 0.72109
C/T 113 (26%) 539 (27%) 652
T/T 315 (72%) 1395 (70%) 1710
6 10Q11_21_MG_428 rs1746048 10 99.5% C/C 315 (72%) 1399 (70%) 1714 1.167
(0.944, 1.444)		 0.15305 0.72109
C/T 113 (26%) 537 (27%) 650
T/T 9 (2%) 51 (3%) 60
7 10Q11_21_MG_439 rs501120 10 96.7% C/C 9 (2%) 51 (3%) 60 0.852
(0.684, 1.062)		 0.15333 0.72109
C/T 100 (24%) 479 (25%) 579
T/T 315 (74%) 1402 (73%) 1717
8 MTHFD1L_MG_423 rs12525353 6 99.4% A/A 0 (0%) 2 (0%) 2 0.649
(0.343, 1.227)		 0.18365 0.72109
A/C 12 (3%) 78 (4%) 90
C/C 424 (97%) 1906 (96%) 2330
9 FMN2_MG_450 rs1456648 1 98.5% G/G 13 (3%) 47 (2%) 60 0.859
(0.686, 1.075)		 0.18500 0.72109
G/T 93 (22%) 511 (26%) 604
T/T 325 (75%) 1411 (72%) 1736
10 SEZ6L_MG_427 rs137209 22 99.6% A/A 47 (11%) 197 (10%) 244 0.891
(0.747, 1.061)		 0.19507 0.72109
A/G 172 (39%) 920 (46%) 1092
G/G 218 (50%) 872 (44%) 1090
11 9P21_3_MG_425 rs1333049 9 99.6% C/C 82 (19%) 335 (17%) 417 1.106
(0.947, 1.292)		 0.20193 0.72109
C/G 212 (49%) 973 (49%) 1185
G/G 143 (33%) 681 (34%) 824
12 9P21_3_MG_421 rs10757283 9 99.3% C/C 110 (25%) 579 (29%) 689 0.905
(0.775, 1.057)		 0.20904 0.72109
C/T 225 (52%) 1003 (51%) 1228
T/T 101 (23%) 401 (20%) 502
13 9P21_3_MG_420 rs10738610 9 99.1% A/A 140 (32%) 664 (34%) 804 0.908
(0.777, 1.061)		 0.22319 0.72109
A/C 211 (49%) 972 (49%) 1183
C/C 83 (19%) 345 (17%) 428
14 10Q11_21_MG_432 rs2146807 10 99.3% C/C 2 (0%) 14 (1%) 16 0.840
(0.622, 1.134)		 0.25520 0.76559
C/T 64 (15%) 327 (16%) 391
T/T 371 (85%) 1642 (83%) 2013
15 9P21_3_MG_451 rs1537378 9 98.2% A/A 56 (13%) 293 (15%) 349 0.926
(0.791, 1.083)		 0.33595 0.87079
A/G 214 (50%) 954 (49%) 1168
G/G 162 (38%) 712 (36%) 874
16 MTHFD1L_MG_449 rs12214306 6 99.1% C/C 1 (0%) 1 (0%) 2 0.779
(0.450, 1.349)		 0.37213 0.87079
C/T 16 (4%) 93 (5%) 109
T/T 415 (96%) 1888 (95%) 2303
17 12Q12_MG_448 rs7970834 12 99.5% G/G 128 (29%) 619 (31%) 747 0.929
(0.791, 1.092)		 0.37370 0.87079
G/T 223 (51%) 1002 (50%) 1225
T/T 86 (20%) 366 (18%) 452
18 SEZ6L_MG_444 rs688034 22 99.5% C/C 244 (56%) 1038 (52%) 1282 1.076
(0.900, 1.287)		 0.41909 0.87079
C/T 164 (38%) 814 (41%) 978
T/T 28 (6%) 135 (7%) 163
19 SEZ6L_MG_426 rs137205 22 99.5% A/A 39 (9%) 150 (8%) 189 0.937
(0.784, 1.120)		 0.47227 0.87079
A/G 164 (38%) 858 (43%) 1022
G/G 234 (54%) 979 (49%) 1213
20 SMAD3_MG_431 rs1866317 15 99.5% C/C 9 (2%) 30 (2%) 39 1.075
(0.859, 1.345)		 0.52638 0.87079
C/G 111 (25%) 469 (24%) 580
G/G 317 (73%) 1489 (75%) 1806
21 19Q12_MG_446 rs7250581 19 98.0% A/A 12 (3%) 49 (3%) 61 1.068
(0.861, 1.325)		 0.54871 0.87079
A/G 105 (24%) 461 (24%) 566
G/G 314 (73%) 1447 (74%) 1761
22 CELSR2_MG_434 rs413380 1 99.5% C/C 400 (92%) 1804 (91%) 2204 1.106
(0.776, 1.576)		 0.57703 0.87079
C/T 36 (8%) 174 (9%) 210
T/T 1 (0%) 10 (1%) 11
23 PSRC1_MG_460 rs599839 1 99.4% A/A 249 (58%) 1142 (57%) 1391 1.050
(0.879, 1.253)		 0.59130 0.87079
A/G 164 (38%) 720 (36%) 884
G/G 20 (5%) 127 (6%) 147
24 5Q21_1_MG_435 rs436495 5 98.8% A/A 30 (7%) 116 (6%) 146 0.953
(0.794, 1.144)		 0.60900 0.87079
A/G 142 (33%) 690 (35%) 832
G/G 261 (60%) 1167 (59%) 1428
25 SMAD3_MG_424 rs12913547 15 99.6% C/C 26 (6%) 140 (7%) 166 1.045
(0.881, 1.241)		 0.61267 0.87079
C/T 186 (43%) 771 (39%) 957
T/T 225 (51%) 1078 (54%) 1303
26 9P21_3_MG_459 rs7865618 9 98.8% A/A 138 (32%) 637 (32%) 775 1.040
(0.893, 1.210)		 0.61378 0.87079
A/G 223 (52%) 973 (49%) 1196
G/G 71 (16%) 365 (18%) 436
27 SEZ6L_MG_457 rs6005016 22 98.9% A/A 2 (0%) 3 (0%) 5 1.092
(0.747, 1.596)		 0.65118 0.87079
A/G 29 (7%) 138 (7%) 167
G/G 401 (93%) 1836 (93%) 2237
28 1Q31_2_MG_453 rs1936982 1 99.0% C/C 50 (12%) 257 (13%) 307 1.037
(0.885, 1.215)		 0.65351 0.87079
C/T 198 (46%) 858 (43%) 1056
T/T 184 (43%) 864 (44%) 1048
29 MIA3_MG_454 rs3008621 1 98.5% A/A 11 (3%) 51 (3%) 62 0.954
(0.770, 1.182)		 0.66663 0.87079
A/G 105 (24%) 475 (24%) 580
G/G 314 (73%) 1443 (73%) 1757
30 MIA3_MG_430 rs17465637 1 99.2% A/A 38 (9%) 147 (7%) 185 1.039
(0.871, 1.238)		 0.67261 0.87079
A/C 153 (35%) 734 (37%) 887
C/C 245 (56%) 1100 (56%) 1345
31 2Q36_3_MG_461 rs2943634 2 97.3% A/A 51 (12%) 246 (13%) 297 1.032
(0.876, 1.215)		 0.70730 0.87079
A/C 194 (46%) 890 (46%) 1084
C/C 176 (42%) 813 (42%) 989
32 5Q21_1_MG_441 rs565928 5 99.5% C/C 275 (63%) 1247 (63%) 1522 1.034
(0.860, 1.242)		 0.72481 0.87079
C/T 139 (32%) 636 (32%) 775
T/T 23 (5%) 104 (5%) 127
33 MTHFD1L_MG_445 rs6922269 6 99.4% A/A 31 (7%) 104 (5%) 135 1.032
(0.853, 1.249)		 0.74604 0.87079
A/G 139 (32%) 696 (35%) 835
G/G 267 (61%) 1184 (60%) 1451
34 10Q11_21_MG_429 rs1746049 10 99.5% C/C 334 (76%) 1515 (76%) 1849 1.038
(0.825, 1.306)		 0.75069 0.87079
C/T 97 (22%) 440 (22%) 537
T/T 6 (1%) 33 (2%) 39
35 2Q36_3_MG_433 rs2972147 2 98.7% C/C 174 (40%) 788 (40%) 962 0.975
(0.833, 1.141)		 0.75110 0.87079
C/T 210 (48%) 909 (46%) 1119
T/T 53 (12%) 270 (14%) 323
36 5Q21_1_MG_436 rs449650 5 99.1% G/G 273 (63%) 1246 (63%) 1519 1.030
(0.858, 1.237)		 0.75176 0.87079
G/T 139 (32%) 627 (32%) 766
T/T 23 (5%) 105 (5%) 128
37 SMAD3_MG_452 rs17228212 15 99.1% C/C 23 (5%) 108 (5%) 131 1.029
(0.850, 1.246)		 0.76712 0.87079
C/T 153 (35%) 721 (36%) 874
T/T 256 (59%) 1152 (58%) 1408
38 5Q21_1_MG_455 rs383830 5 99.0% A/A 23 (5%) 103 (5%) 126 0.977
(0.813, 1.175)		 0.80756 0.89256
A/T 138 (32%) 630 (32%) 768
T/T 271 (63%) 1246 (63%) 1517
39 SEZ6L_MG_442 rs6005015 22 99.5% C/C 40 (9%) 179 (9%) 219 0.982
(0.823, 1.172)		 0.84190 0.90666
C/T 182 (42%) 857 (43%) 1039
T/T 215 (49%) 952 (48%) 1167
40 2Q36_3_MG_447 rs7597168 2 99.4% C/C 247 (57%) 1117 (56%) 1364 0.985
(0.824, 1.178)		 0.87064 0.90787
C/T 165 (38%) 756 (38%) 921
T/T 25 (6%) 112 (6%) 137
41 CELSR2_MG_438 rs4970834 1 99.5% C/C 276 (63%) 1238 (62%) 1514 1.015
(0.832, 1.237)		 0.88625 0.90787
C/T 142 (32%) 665 (33%) 807
T/T 19 (4%) 83 (4%) 102
42 9P21_3_MG_437 rs496892 9 99.0% C/C 104 (24%) 490 (25%) 594 1.000
(0.858, 1.166)		 0.99642 0.99642
C/T 234 (54%) 1027 (52%) 1261
T/T 98 (22%) 458 (23%) 556

stratified by sex, adjusted for: cohort nonhdl hdla bmi bpm dsmoker hisdiab1

Updated on 2008-12-08