SYTTY
CHLORINATED IMPURITIES IN DRINKING WATER - MUTAGENIC COMPOUNDS AND THE MECHANISMS OF CANCER
Project leader: Hannu Komulainen, Laboratory of Toxicology, National
Public Health Institute, P.O.Box 95, FIN-70701 Kuopio, Finland, tel. +358-17-201
322, fax: +358-17-201 265, e-mail: Hannu.Komulainen@ktl.fi
PUBLICATIONS
(Updated May 13, 2002)
Articles in international scientific journals
Komulainen H., Hakulinen P., Servomaa K., Makkonen K., Vasara R., Mäki-Paakkanen J., Kosma V-M.: No consistent pattern of mutations in p53 and ras genes in liver tumors of rat treated with the drinking water mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX). Environmental Mol. Mutagenesis, 2000, 36:292-300.
Hakulinen P., Kosma V.-M., Komulainen H.: Expression of p53 and p21 Ki-ras proteins in rat thyroid gland tumors induced by 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX). Anticancer Res. 2002, in press.
Komulainen H., Tuominen R.K., Kosma V-M., Huuskonen H.: 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX), a rat thyroid gland carcinogen, does not affect serum levels of TSH and thyroid hormones. Environm. Toxicol. Pharmacol., 2000, 8: 267-273.
Mäki-Pakkanen J., Laaksonen M., Munter T., Kronberg L., Komulainen H.: Comparable DNA and chromosome damage in Chinese hamster ovary cells by chlorohydroxyfuranones. Environm. Mol. Mutagenesis, 2001, 38:297-305.
Laaksonen M., Mäki-Paakkanen J., Komulainen H.: Enhancement of
3-methylcholanthrene-induced neoplastic transformation by 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone
in the two-stage transformation assay in C3H 10T1/2 cells. Arch. Toxicol,
2001,75:613-617.